Grandilodines A-C, biologically active indole alkaloids from Kopsia grandifolia

Yap WS 1 , Gan CY , Low YY , Choo YM , Etoh T , Hayashi M Show all authors , Komiyama K , Kam TS

Affiliations 

  • 1 Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
J Nat Prod, 2011 May 27;74(5):1309-12.
PMID: 21428274 DOI: 10.1021/np200008g

Abstract

Three new indole alkaloids (1-3), named grandilodines A-C, and five known ones were obtained from the Malayan Kopsia grandifolia. The structures were established using NMR and MS analyses and, in the case of 1 and 2, were confirmed by X-ray diffraction analyses. Alkaloids 1, 3, and lapidilectine B (8) were found to reverse multidrug resistance in vincristine-resistant KB cells.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications