Corynanthean, eburnan, secoleuconoxine, and pauciflorine alkaloids from Kopsia pauciflora

Gan CY 1 , Yoganathan K 2 , Sim KS 3 , Low YY 4 , Lim SH 4 , Kam TS 5

Affiliations 

  • 1 University Malaysia of Computer Science and Engineering, Jalan Alamanda 2, Precint 1, 62000 Putrajaya, Malaysia
  • 2 Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, 07-01 Matrix, Singapore 138671, Singapore
  • 3 Institute of Biological Sciences, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 4 Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 5 Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: tskam@um.edu.my
Phytochemistry, 2014 Dec;108:234-42.
PMID: 25442910 DOI: 10.1016/j.phytochem.2014.09.014

Abstract

Eleven indole alkaloids, comprising four corynanthean, two eburnane, one aspidofractinine, one secoleuconoxine, one andranginine, and two pauciflorine type alkaloids were isolated from the stem-bark and leaf extracts of Kopsia pauciflora. Their structures were determined using NMR and MS analyses. The catharinensine type alkaloid kopsirensine B and the secoleuconoxine alkaloid arboloscine A showed moderate to weak activity in reversing MDR in vincristine-resistant KB cells. The alkaloid content was markedly different compared to that of a sample from Malaysian Borneo.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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