• 1 Atta-ur-Rahman Institute for Natural Product Discovery , Universiti Teknologi MARA Selangor Branch, Puncak Alam Campus , 42300 Bandar Puncak Alam , Selangor Malaysia
  • 2 Department of Chemistry, Faculty of Science , University Malaya , 50603 Kuala Lumpur , Malaysia
  • 3 Department of Chemistry, Faculty of Resource Science and Technology , Universiti Malaysia Sarawak , 94300 Kota Semarahan , Sarawak , Malaysia
  • 4 School of Pharmacy , International Medical University , Jalan Jalil Perkasa 19, Bukit Jalil , 57000 Bukit Jalil, Kuala Lumpur , Malaysia
  • 5 Natural Products Inc. , Evanston , Illinois 60203 , United States
J Nat Prod, 2019 09 27;82(9):2430-2442.
PMID: 31433181 DOI: 10.1021/acs.jnatprod.8b01067


Eight new bis-styryllactones, goniolanceolatins A-H (1-8), possessing a rare α,β-unsaturated δ-lactone moiety with a (6S)-configuration, were isolated from the CH2Cl2 extract of the stembark and roots of Goniothalamus lanceolatus Miq., a plant endemic to Malaysia. Absolute structures were established through extensive 1D- and 2D-NMR data analysis, in combination with electronic dichroism (ECD) data. All of the isolates were evaluated for their cytotoxicity against human lung and colorectal cancer cell lines. Compounds 2 and 4 showed cytotoxicity, with IC50 values ranging from 2.3 to 4.2 μM, and were inactive toward human noncancerous lung and colorectal cells. Compounds 1, 3, 6, 7, and 8 showed moderate to weak cytotoxicity. Docking studies of compounds 2 and 4 showed that they bind with EGFR tyrosine kinase and cyclin-dependent kinase 2 through hydrogen bonding interactions with the important amino acids, including Lys721, Met769, Asn818, Arg157, Ile10, and Glu12.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.