• 1 Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
J Nat Prod, 2008 Sep;71(9):1591-4.
PMID: 18778099 DOI: 10.1021/np800435c


Seven new indole alkaloids of the Aspidosperma type, jerantinines A-G (1-7), were isolated from a leaf extract of the Malayan Tabernaemontana corymbosa. The structures were established using NMR and MS analysis. Five of the alkaloids isolated and two derivatives (1-5, 8, 9) displayed pronounced in vitro cytotoxicity against human KB cells (IC50 < 1 microg/mL).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.