Affiliations 

  • 1 Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia
J Nat Prod, 2014 Nov 26;77(11):2504-12.
PMID: 25333996 DOI: 10.1021/np500589u

Abstract

Seven new indole alkaloids (1-7) comprising four vobasine, two tacaman, and one corynanthe-tryptamine bisindole alkaloid were isolated from the stem-bark extract of a Malayan Tabernaemontana. Two of the new vobasine alkaloids (1, 3), as well as 16-epivobasine (15) and 16-epivobasenal (17), showed appreciable cytotoxicity toward KB cells (IC50 ca. 5 μg/mL). The structure of the known Tabernaemontana alkaloid tronoharine (8) was revised based on newly acquired NMR data, as well as X-ray diffraction analysis.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.