Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan

Tan KY 1 , Liew ST 2 , Tan QY 2 , Abdul-Rahman FN 2 , Azmi NI 2 , Sim SM 3 Show all authors , Tan NH 1 , Khomvilai S 4 , Sitprija V 4 , Tan CH 5

Affiliations 

  • 1 Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 2 Department of Biomedical Sciences, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 4 Queen Saovabha Memorial Institute, Thai Red Cross Society, Rama IV Road, Bangkok, Thailand
  • 5 Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: tanch@um.edu.my
Toxicon, 2019 Mar 15;160:55-58.
PMID: 30797900 DOI: 10.1016/j.toxicon.2019.02.010

Abstract

Gel filtration chromatography and gel electrophoresis revealed minimal protein degradation in lyophilized antivenoms which were 2-year expired (Hemato Polyvalent, Neuro Polyvalent; Thailand) and 18-year expired (Hemato Bivalent, Neuro Bivalent; Taiwan). All expired antivenoms retained immunological binding activity, and were able to neutralize the hemotoxic or neurotoxic as well as lethal effects of the homologous snake venoms. The findings show that antivenoms under proper storage conditions may remain relatively stable beyond the indicated shelf life.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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