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Systemic antibody response to nano-size calcium phospate biocompatible adjuvant adsorbed HEV-71 killed vaccine

Saeed MI 1 , Omar AR 2 , Hussein MZ 3 , Elkhidir IM 4 , Sekawi Z 1

Affiliations 

  • 1 Department of Microbiology and Parasitology, University of Putra Malaysia, Medical Faculty, Serdang, Malaysia
  • 2 University of Putra Malaysia, Institute of Biosciences, Serdang, Malaysia
  • 3 University of Putra Malaysia, Institute of Advanced Technology, Serdang, Malaysia
  • 4 Department of Microbiology and Parasitology, University of Khartoum, Faculty of Medicine, Sudan, Malaysia
Clin Exp Vaccine Res, 2015 Jan;4(1):88-98.
PMID: 25649429 DOI: 10.7774/cevr.2015.4.1.88

Abstract

Since 1980s, human enterovirus-71 virus (HEV-71) is one of the common infectious disease in Asian Pacific region since late 1970s without effective commercial antiviral or protective vaccine is unavailable yet. The work examines the role of vaccine adjuvant particle size and the route of administration on postvaccination antibody response towards HEV-71 vaccine adsorbed to calcium phosphate (CaP) adjuvant.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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