Review: Beta-thalassemia and molecular chaperones

Sumera A 1 , Radhakrishnan A 2 , Baba AA 2 , George E 3

Affiliations 

  • 1 Department of Pathology, School of Medicine, International Medical University, Kuala Lumpur, Malaysia. Electronic address: afshansumera@imu.edu.my
  • 2 Department of Pathology, School of Medicine, International Medical University, Kuala Lumpur, Malaysia
  • 3 Department of Pathology, University Putra Malaysia, Kuala Lumpur, Malaysia
Blood Cells Mol. Dis., 2015 Apr;54(4):348-52.
PMID: 25648458 DOI: 10.1016/j.bcmd.2015.01.008

Abstract

Thalassemia is known as a diverse single gene disorder, which is prevalent worldwide. The molecular chaperones are set of proteins that help in two important processes while protein synthesis and degradation include folding or unfolding and assembly or disassembly, thereby helping in cell homeostasis. This review recaps current knowledge regarding the role of molecular chaperones in thalassemia, with a focus on beta thalassemia.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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