The purpose of the present research was to evaluate the phytochemical content and analgesic effect of Caralluma edulis
(Ce.Cr). Established methods were used for phytochemical analysis of plant. The anti-nociceptic activity of Ce.Cr was
scrutinized using acetic acid-induced writhings, tail immersion and hot plate methods. Ce.Cr was tested positive for the
presence of therapeutically active metabolites such as alkaloids, flavonoids, glycosides, phenol, tannins, terpenoids and
saponins. Ce.Cr at the dose of 10, 30 and 100 mg/kg inhibited acetic acid-induced abdominal writhes and increase the
latency time to thermal stimuli in both tail immersion and hot plate tests, similar to standard drug. These results showed
that the ethanolic extract of Caralluma edulis possesses anti-nociceptive property.