Isolation and identification of N6-isopentenyladenosine as the cytotoxic constituent of a marine sponge Oceanapia sp

Nakamukai S 1 , Ise Y 2 , Ohtsuka S 3 , Okada S 1 , Matsunaga S 1

Affiliations 

  • 1 Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Tokyo , Japan
  • 2 Center for Marine and Coastal Studies, Universiti Sains Malaysia , Penang , Malaysia
  • 3 Takehara Marine Science Station, Hiroshima University , Takehara , Hiroshima , Japan
Biosci Biotechnol Biochem, 2019 Nov;83(11):1985-1988.
PMID: 31250707 DOI: 10.1080/09168451.2019.1630258

Abstract

N6-Isopentenyladenosine (i6A) was isolated from a marine sponge Oceanapia sp. as the major cytotoxic constituent along with N6-isopentenyladenosine 5'-monophosphate (i6AP) which was inactive. The structures of i6A and i6AP were assigned by a combination of the analysis of NMR spectroscopy and mass spectrometry. This is the first isolation of i6A and i6AP from a marine sponge.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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