Scrobiculosides A and B from the deep-sea sponge Pachastrella scrobiculosa

Jomori T 1 , Shiroyama S 1 , Ise Y 2 , Kohtsuka H 3 , Matsuda K 1 , Kuranaga T 1 Show all authors , Wakimoto T 4

Affiliations 

  • 1 Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan
  • 2 Center for Marine and Coastal Studies (CEMACS), Universiti Sains Malaysia (USM), 11800, Nibong Tebal, Penang, Malaysia
  • 3 Misaki Marine Biological Station (MMBS), Graduate School of Science, The University of Tokyo, Misaki, Miura, Kanagawa, 238-0225, Japan
  • 4 Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan. wakimoto@pharm.hokudai.ac.jp
J Nat Med, 2019 Sep;73(4):814-819.
PMID: 31054009 DOI: 10.1007/s11418-019-01315-6

Abstract

Two new steroidal saponins, scrobiculosides A and B, were isolated from the deep-sea sponge Pachastrella scrobiculosa, collected at a depth of 200 m off Miura Peninsula, Japan. The aglycones of scrobiculosides A and B feature a vinylic cyclopropane and a ∆24,25 exomethylene on the side chains, respectively. Both saponins have a common sugar moiety composed of β-D-galactopyranosyl-(1 → 2)-6-acetyl-β-D-glucopyranoside, with the exception of an acetyl group on C6″ in scrobiculoside A. Scrobiculoside A exhibited cytotoxicity against HL-60 and P388 cells, with IC50 values of 52 and 61 μM, respectively.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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