Structures of triterpenoids from the leaves of Lansium domesticum

Matsumoto T 1 , Kitagawa T 1 , Ohta T 2 , Yoshida T 2 , Imahori D 1 , Teo S 3 Show all authors , Ahmad HSB 3 , Watanabe T 4

Affiliations 

  • 1 Department of Public Health, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan
  • 2 Faculty of Pharmaceutical Sciences, Nagasaki International University, Nagasaki, 859-3298, Japan
  • 3 Forest Department Sarawak, Wisma Sumber Alam, Jalan Stadium, Petra Jaya, 93660, Kuching, Sarawak, Malaysia
  • 4 Department of Public Health, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan. watanabe@mb.kyoto-phu.ac.jp
J Nat Med, 2019 Sep;73(4):727-734.
PMID: 31104253 DOI: 10.1007/s11418-019-01319-2

Abstract

From the methanolic extract of the leaves of Lansium domesticum, three new onoceranoid-type triterpenoids, lansium acids X-XII and a new cycloartane-type triterpene, lansium acid XIII, were isolated. The chemical structures of the isolated new compounds were elucidated on the basis of chemical/physicochemical evidence. For new onoceranoid-type triterpenoids, the absolute configurations were established by comparison of experimental and predicted electronic circular dichroism (ECD) data. The isolated onoceranoid-type triterpenoids showed antimutagenic effects in the Ames assay against 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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