Comparison and evaluation of physicochemical properties of the six betamethasone·17-valerate creams available locally were studied. Tests that were conducted include stiffness/hardness, grittiness. colour, odour, homogeneity (phase separation), pH, weight of loss, tackiness (stickiness) and microscopic examination. A point grading system was used 10 assess and compare the products. Results revealed that BetnovateT and CamnovaleT to be the most superior followed by BeavateT, SetrosoneT, BetasoneT and UniflexT