Distinct pattern of chromosomal alterations and pathways in tongue and cheek squamous cell carcinoma

Vincent-Chong VK 1 , Karen-Ng LP 2 , Abdul Rahman ZA 1 , Yang YH 3 , Anwar A 4 , Zakaria Z 5 Show all authors , Jayaprasad Pradeep P 2 , Kallarakkal TG 6 , Kiong Tay K 7 , Thomas Abraham M 7 , Mazlipah Ismail S 1 , Zain RB 2

Affiliations 

  • 1 Department of Oral Maxillofacial Surgery, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
  • 2 Oral Cancer Research and Coordinating Center, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Department of Dental Hygiene, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung
  • 4 Sengenics Sdn Bhd, Petaling Jaya, Selangor Darul Ehsan, Malaysia
  • 5 Department of Haematology, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia
  • 6 Department of Oral Pathology, Oral Medicine and Periodontology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
  • 7 Oral Health Division, Ministry of Health, Putrajaya, Malaysia
Head Neck, 2014 Sep;36(9):1268-1278.
PMID: 31615169 DOI: 10.1002/hed.23448

Abstract

BACKGROUND: The purpose of this study was to investigate the cause of behavioral difference between tongue and cheek squamous cell carcinomas (SCCs) by verifying the copy number alterations (CNAs).

METHODS: Array comparative genomic hybridization (aCGH) was used to profile unique deletions and amplifications that are involved with tongue and cheek SCC, respectively. This was followed by pathway analysis relating to CNA genes from both sites.

RESULTS: The most frequently amplified regions in tongue SCC were 4p16.3, 11q13.4, and 13q34; whereas the most frequently deleted region was 19p12. For cheek SCC, the most frequently amplified region was identified on chromosome 9p24.1-9p23; whereas the most common deleted region was located on chromosome 8p23.1. Further analysis revealed that the most significant unique pathway related to tongue and cheek SCCs was the cytoskeleton remodeling and immune response effect on the macrophage differentiation pathway.

CONCLUSION: This study has showed the different genetic profiles and biological pathways between tongue and cheek SCCs. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1268-1278, 2014.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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