Gut bacteria characteristic of the infant microbiota down-regulate inflammatory transcriptional responses in HT-29 cells

Pathmanathan SG 1 , Lawley B 2 , McConnell M 2 , Baird MA 3 , Tannock GW 2

Affiliations 

  • 1 Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand; Department of Medical Sciences, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia (USIM), Kuala Lumpur, Malaysia. Electronic address: gowri@usim.edu.my
  • 2 Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
  • 3 Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
Anaerobe, 2020 Feb;61:102112.
PMID: 31629806 DOI: 10.1016/j.anaerobe.2019.102112

Abstract

Immuno-modulatory effects of infant gut bacteria were tested on poly(I:C) stimulated HT-29 intestinal epithelial cells. Blautia producta, Bacteroides vulgatus, Bacteroides fragilis and Bacteroides thetaiotaomicron decreased transcription of poly(I:C)-induced inflammatory genes. Modulation of basal level and poly(I:C)-induced IL-8 secretion varied between bacterial species, and between heat treated and non-heat treated bacterial cells.

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