Gymnemic acid alleviates gut barrier disruption and lipid dysmetabolism via regulating gut microbiota in HFD hamsters

Li Y 1 , Sun M 2 , Tian X 3 , Bao T 3 , Yu Q 3 , Ma NL 4 Show all authors , Gan R 5 , Cheang WS 6 , Wu X 7

Affiliations 

  • 1 Chinese Academy of Sciences, Tianjin Institute of Industrial Biotechnology, Tianjin, China; TIB-UM Joint Laboratory of Synthetic Biology for Traditional Chinese Medicine, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, China
  • 2 Air Force Medical Center of People's Liberation Army, Beijing, China; College of food science & nutritional engineering, China Agricultural University, Beijing, China
  • 3 Chinese Academy of Sciences, Tianjin Institute of Industrial Biotechnology, Tianjin, China
  • 4 BIOSES Research Interest Group, Faculty of Science & Marine Environment, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia; Center for Global Health Research (CGHR), Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India
  • 5 Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore; Department of Food Science and Nutrition, Faculty of Science, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China
  • 6 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China; TIB-UM Joint Laboratory of Synthetic Biology for Traditional Chinese Medicine, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, China
  • 7 Chinese Academy of Sciences, Tianjin Institute of Industrial Biotechnology, Tianjin, China; TIB-UM Joint Laboratory of Synthetic Biology for Traditional Chinese Medicine, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, China. Electronic address: wuxin@tib.cas.cn
J Nutr Biochem, 2024 Nov;133:109709.
PMID: 39053860 DOI: 10.1016/j.jnutbio.2024.109709

Abstract

Gut microbiota dysbiosis and gut barrier disruption are key events associated with high-fat diet (HFD)-induced systemic metabolic disorders. Gymnemic acid (GA) has been reported to have an important role in alleviating HFD-induced disorders of glycolipid metabolism, but its regulatory role in HFD-induced disorders of the gut microbiota and gut barrier function has not been elucidated. Here we showed that GA intervention in HFD-induced hamsters increased the relative abundance of short-chain fatty acid (SCFA)-producing microbes including Lactobacillus (P

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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