Preclinical Evidence for the Pharmacological Actions of Glycyrrhizic Acid: A Comprehensive Review

Rehman MU 1 , Farooq A 2 , Ali R 3 , Bashir S 4 , Bashir N 4 , Majeed S 5 Show all authors , Taifa S 6 , Ahmad SB 4 , Arafah A 1 , Sameer AS 7 , Khan R 8 , Qamar W 9 , Rasool S 10 , Ahmad A 8

Affiliations 

  • 1 Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
  • 2 RAKCOPS, RAK Medical and Health Sciences University, Ras AL Khaimah, United Arab Emirates
  • 3 Division of Veterinary Pathology, Faculty of Veterinary Science and Animal Husbandry, SKUAST-Kashmir, Shuhama, JandK, India
  • 4 Division of Veterinary Biochemistry, Faculty of Veterinary Science and Animal Husbandry, SKUAST-Kashmir, Shuhama, JandK, India
  • 5 Division of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Science and Animal Husbandry, SKUAST-Kashmir, Shuhama, JandK, India
  • 6 Division of Animal Nutrition, Faculty of Veterinary Science and Animal Husbandry, SKUAST-Kashmir, Shuhama, JandK, India
  • 7 Department of Basic Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), King Abdullah International Medical Research Centre (KAIMRC), Jeddah, Saudi Arabia
  • 8 Department of Nano-therapeutics, Institute of Nanoscience and Technology (DST-INST), Mohali, Punjab, India
  • 9 Department of Pharmacology and Toxicology and Central Laboratory, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
  • 10 Forest Biotech Lab, Department of Forest Mana pgement, Faculty of Forestry, University Putra Malaysia, Serdang, Selangor, Malaysia
Curr Drug Metab, 2020;21(6):436-465.
PMID: 32562521 DOI: 10.2174/1389200221666200620204914

Abstract

Glycyrrhiza glabra L. (Family: Fabaceae) is one of the important traditional medicinal plant used extensively in folk medicine. It is known for its ethnopharmacological value in curing a wide variety of ailments. Glycyrrhizin, an active compound of G. glabra, possesses anti-inflammatory activity due to which it is mostly used in traditional herbal medicine for the treatment and management of chronic diseases. The present review is focused extensively on the pharmacology, pharmacokinetics, toxicology, and potential effects of Glycyrrhizic Acid (GA). A thorough literature survey was conducted to identify various studies that reported on the GA on PubMed, Science Direct and Google Scholar.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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