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Inhibitory effects of tangeretin and trans-ethyl caffeate on the HMG-CoA reductase activity: Potential agents for reducing cholesterol levels

Pangestika I 1 , Oksal E 1 , Tengku Muhammad TS 1 , Amir H 2 , Syamsumir DF 1 , Wahid MEA 3 Show all authors , Andriani Y 1

Affiliations 

  • 1 Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Mengabang Telipot, 21030 Kuala Nerus, Terengganu, Malaysia
  • 2 Educational Chemistry Program, Faculty of Teacher Training and Education, Bengkulu University, Bengkulu 38371, Indonesia
  • 3 School of Fisheries and Aquaculture Sciences, Universiti Malaysia Terengganu, Mengabang Telipot, 21030 Kuala Nerus, Terengganu, Malaysia
Saudi J Biol Sci, 2020 Aug;27(8):1947-1960.
PMID: 32714018 DOI: 10.1016/j.sjbs.2020.06.010

Abstract

One of the pathways to reduce cholesterol production in the liver is through the inhibition of HMG-Coa reductase (HMGCR) by current drugs, statins. However, these have side effects if consumed in prolonged periods. Tangeretin and trans-ethyl caffeate as alternative drugs in reducing hypercholesterolemia and preventing atherosclerosis have never been reported. Their effects on inhibiting HMGCR activity were investigated through enzymatic method (in vitro and in vivo). The toxicity property was analyzed on the Serum Glutamate Oxalate Transaminase (SGOT)/Serum Glutamate Piruvate Transaminase (SGPT) levels and rat liver histology. The results showed that both compounds inhibited HMGCR activity significantly compare to the control simvastatin (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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