Effect of strontium substitution on structural, sinterability, physicomechanical and biological properties of akermanite ceramic

Mohammadi H 1 , Baba Ismail YM 2 , Shariff KA 3 , Mohd Noor AF 3

Affiliations 

  • 1 Biomaterials Research Group, School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Engineering Campus, 14300, Nibong Tebal, Penang, Malaysia; Department of Mechanical and Manufacturing Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor Darul Ehsan, Malaysia. Electronic address: hmbiomater@ukm.edu.my
  • 2 Biomaterials Research Group, School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Engineering Campus, 14300, Nibong Tebal, Penang, Malaysia. Electronic address: yannymarliana@usm.my
  • 3 Biomaterials Research Group, School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Engineering Campus, 14300, Nibong Tebal, Penang, Malaysia
J Mech Behav Biomed Mater, 2021 04;116:104379.
PMID: 33561674 DOI: 10.1016/j.jmbbm.2021.104379

Abstract

Despite the excellent in vitro and in vivo performance of akermanite ceramic, its poor toughness and strength limit the biomedical application, particularly under load. Herein, the incorporation of strontium enhanced the physicomechanical properties of akermanite and this is ascribed to the decrease in grain size and better sinterability. To investigate the biological performance, the bone-cell interaction with sintered pellets was assessed by in vitro biocompatibility with human fetal osteoblast cell (hFOB). The cell viability using MTT assay revealed that the Ca1.9Sr0.1MgSi2O7 pellets with finer grain size provided better interaction between the cells compared to the unsubstituted counterpart with larger grain size. Our findings highlighted that the synergistic effect of controlled degradation rate and release of Sr2+ into the medium enhanced the in vitro biological properties of akermanite-based materials.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications