Effect of short-term ketogenic diet on end-tidal carbon dioxide

Vijayam B 1 , Malarvili MB 1 , Md Shakhih MF 1 , Omar N 1 , Wahab AA 2

Affiliations 

  • 1 School of Biomedical Engineering & Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia Skudai 81310, Johor, Malaysia
  • 2 School of Biomedical Engineering & Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia Skudai 81310, Johor, Malaysia; Medical Devices and Technology Centre (MEDITEC), Universiti Teknologi Malaysia, Skudai 81310, Johor, Malaysia. Electronic address: asnida@biomedical.utm.my
Clin Nutr ESPEN, 2021 04;42:124-131.
PMID: 33745565 DOI: 10.1016/j.clnesp.2021.02.005

Abstract

BACKGROUND & AIMS: Previous studies have shown that end-tidal carbon dioxide (EtCO2) is lower with the presence of supraphysiological ketones as in the case of chronic ketogenic diet (KD) and diabetic ketoacidosis (DKA). This study aimed to determine changes in EtCO2 upon short term KD.

METHODS: Healthy subjects were screened not to have conditions that exerts abnormal EtCO2 nor contraindicated for KD. Subjects underwent seven days of KD while the EtCO2 and blood ketone (beta-hydroxybutyrate; β-OHB) parameters were sampled at day zero (t0) and seven (t7) of ketosis respectively. Statistically, the t-test and Pearson's coefficient were conducted to determine the changes and correlation of both parameters.

RESULTS: 12 subjects completed the study. The mean score ± standard deviation (SD) for EtCO2 were 35.08 ± 3.53 and 35.67 ± 3.31 mm Hg for t0 and t7 respectively. The mean score ±SD for β-OHB were 0.07 ± 0.08 and 0.87 ± 0.84 mmol/L for t0 and t7 respectively. There was no significant difference of EtCO2 between the period of study (p > 0.05) but the β-OHB increased during t7 (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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