Introduction of electronic cigarette (EC) in the global market posed a new challenge to public health experts
in terms of controlling the widespread use of the device among general population. This systematic review aimed
to explore the trend of EC use among population of adults reported in literature across multiple regions. Using
Scopus search engine and several screening strategies, specific keywords were applied in the advanced search
field and the search have yielded a total of 33 articles. The key findings include i) the existence of dual users of EC
and conventional cigarette smokers and ii) the emergence of EC users who previously never smoked reported
among adult populations. The present study suggests that future tobacco control strategies should be strengthen
in preventing the initiation of nicotine addiction among non-smoking population and established nicotine
replacement therapy instead of EC should be further promoted smokers as a method to quit smoking.