Introduction: This paper provides an overview of chemical toxic pollution in Pasir Gudang industrial area Johor
Malaysia. It discussed the health symptoms, argument of the psychology manifestation among children and the
application of biomarkers and monitoring systems in chemical detection. Methods: The systematic search was
conducted for four digital scientific journal databases: Science Direct, SCOPUS, PubMed and Google Scholar
with a specified keyword. Results: Seven (7) chemicals were related to this incident namely; Methane,
Hydrogen chloride, Acrylonitrile, Acrolein, Benzene, Xylene, and Methyl mercaptan. These chemicals are
mainly generated from industrial activity and easily breakdown through interaction with other chemicals
and sunlight. Inhalation is the major route of exposure and the major symptoms of these chemicals are headache,
nausea, vomiting, breathing difficulties, eye irritation, chest tightness, and wheezing. There is no clear
evidence to indicate that the victims in this incident are having a psychological manifestation since all chemicals
involved are proven to cause the reported symptoms. Conclusion: Industrial chemicals are potential
to produce toxic gas in the air through reaction with other substances or rays and causes acute health symptoms.
Diagnose all post-emergency illnesses including mental and physical health is needed. Biomarker testing should
consider a specified period after exposure occurs as the reactivity of some types of chemical and its short half-life,
rendered limited for use as markers of exposure in the body.