Affiliations 

  • 1 Institute of Artificial Intelligence, University of Science and Technology Beijing, Beijing, China
  • 2 School of Information Science and Engineering, Yanshan University, Qinhuangdao, China; The Key Laboratory for Computer Virtual Technology and System Integration of Hebei Province, Yanshan University, Qinhuangdao, China
  • 3 Department of Biomedical Engineering, Chengde Medical University, Chengde, China
  • 4 Faculty of Engineering, Universiti Putra Malaysia, Serdang, Malaysia
  • 5 The National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
  • 6 Department of Neurology, The Rocket Force General Hospital of Chinese People's Liberation Army, Beijing, China
  • 7 School of Mathematics and Information Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao, China. Electronic address: yhzhou168@163.com
J Neurosci Methods, 2021 Nov 01;363:109353.
PMID: 34492241 DOI: 10.1016/j.jneumeth.2021.109353

Abstract

BACKGROUND: The application of deep learning models to electroencephalogram (EEG) signal classification has recently become a popular research topic. Several deep learning models have been proposed to classify EEG signals in patients with various neurological diseases. However, no effective deep learning model for event-related potential (ERP) signal classification is yet available for amnestic mild cognitive impairment (aMCI) with type 2 diabetes mellitus (T2DM).

METHOD: This study proposed a single-scale multi-input convolutional neural network (SSMICNN) method to classify ERP signals between aMCI patients with T2DM and the control group. Firstly, the 18-electrode ERP signal on alpha, beta, and theta frequency bands was extracted by using the fast Fourier transform, and then the mean, sum of squares, and absolute value feature of each frequency band were calculated. Finally, these three features are converted into multispectral images respectively and used as the input of the SSMICNN network to realize the classification task.

RESULTS: The results show that the SSMICNN can fuse MSI formed by different features, SSMICNN enriches the feature quantity of the neural network input layer and has excellent robustness, and the errors of SSMICNN can be simultaneously transmitted to the three convolution channels in the back-propagation phase. Comparison with Existing Method(s): SSMICNN could more effectively identify ERP signals from aMCI with T2DM from the control group compared to existing classification methods, including convolution neural network, support vector machine, and logistic regression.

CONCLUSIONS: The combination of SSMICNN and MSI can be used as an effective biological marker to distinguish aMCI patients with T2DM from the control group.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.