5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment

Yusefi M 1 , Lee-Kiun MS 2 , Shameli K 3 , Teow SY 4 , Ali RR 1 , Siew KK 5 Show all authors , Chan HY 2 , Wong MM 2 , Lim WL 5 , Kuča K 6

Affiliations 

  • 1 Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, Malaysia
  • 2 Department of Medical Sciences, School of Medical and Life Sciences, Sunway University, Jalan Universiti, Bandar Sunway, 47500, Selangor Darul Ehsan, Malaysia
  • 3 Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, Malaysia. Electronic address: kamyarshameli@gmail.com
  • 4 Department of Medical Sciences, School of Medical and Life Sciences, Sunway University, Jalan Universiti, Bandar Sunway, 47500, Selangor Darul Ehsan, Malaysia. Electronic address: ronaldt@sunway.edu.my
  • 5 Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Jalan Bandar Sunway, 47500, Selangor Darul Ehsan, Malaysia
  • 6 Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, Malaysia; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech Republic
Carbohydr Polym, 2021 Dec 01;273:118523.
PMID: 34560940 DOI: 10.1016/j.carbpol.2021.118523

Abstract

Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-fluorouracil carrier abbreviated as MC/5-FU for potential colorectal cancer treatments. Several analyses indicated the multifunctional properties of MC/5-FU bionanocomposites. Transmission and scanning electron microscopy study demonstrated that Fe3O4 nanofillers covered the cellulose matrix. The drug release from MC/5-FU was evaluated under various pH and temperature conditions, showing the maximum release at pH 7.4 and 44.2 °C. In in vitro anticancer assay, MC/5-FU exhibited enhanced selectivity and anticancer actions against 2D monolayer and 3D tumour spheroid models colorectal cancer cells. The anticancer effects of MC/5-FU with magnetic targeting and heat induction were also examined. This easily synthesized MC/5-FU indicated the potential in application as a low-cost drug formulation for colorectal cancer treatments.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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