Affiliations 

  • 1 Department of Computer Science and Engineering, Indian Institute of Technology Roorkee, Roorkee, India
  • 2 Department of Mechanical and Industrial Engineering, Indian Institute of Technology Roorkee, Roorkee, India
  • 3 Department of Computer Science and Engineering, Indian Institute of Technology Roorkee, Roorkee, India. rkumar9@cs.iitr.ac.in
  • 4 Institute of Integrated Cell Material Sciences (WPI-iCeMS), Kyoto University of Advanced Study, Kyoto, Japan
  • 5 Centre for Research and Graduate Studies, University of Cyberjaya, Cyberjaya, Malaysia
Phys Eng Sci Med, 2021 Dec;44(4):1257-1271.
PMID: 34609703 DOI: 10.1007/s13246-021-01060-9

Abstract

According to the World Health Organization (WHO), novel coronavirus (COVID-19) is an infectious disease and has a significant social and economic impact. The main challenge in fighting against this disease is its scale. Due to the outbreak, medical facilities are under pressure due to case numbers. A quick diagnosis system is required to address these challenges. To this end, a stochastic deep learning model is proposed. The main idea is to constrain the deep-representations over a Gaussian prior to reinforce the discriminability in feature space. The model can work on chest X-ray or CT-scan images. It provides a fast diagnosis of COVID-19 and can scale seamlessly. The work presents a comprehensive evaluation of previously proposed approaches for X-ray based disease diagnosis. The approach works by learning a latent space over X-ray image distribution from the ensemble of state-of-the-art convolutional-nets, and then linearly regressing the predictions from an ensemble of classifiers which take the latent vector as input. We experimented with publicly available datasets having three classes: COVID-19, normal and pneumonia yielding an overall accuracy and AUC of 0.91 and 0.97, respectively. Moreover, for robust evaluation, experiments were performed on a large chest X-ray dataset to classify among Atelectasis, Effusion, Infiltration, Nodule, and Pneumonia classes. The results demonstrate that the proposed model has better understanding of the X-ray images which make the network more generic to be later used with other domains of medical image analysis.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.