The Synthesis, Characterization and Applications of Polyhydroxyalkanoates (PHAs) and PHA-Based Nanoparticles

Samrot AV 1 , Samanvitha SK 2 , Shobana N 3 , Renitta ER 4 , Senthilkumar P 5 , Kumar SS 6 Show all authors , Abirami S 7 , Dhiva S 8 , Bavanilatha M 3 , Prakash P 3 , Saigeetha S 3 , Shree KS 3 , Thirumurugan R 9

Affiliations 

  • 1 School of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jalan SP2, Bandar Saujana Putra, Jenjarom 42610, Selangor, Malaysia
  • 2 Department of Biotechnology, Shanmugha Arts, Science, Technology & Research Academy, Thanjavur 613401, Tamil Nadu, India
  • 3 Department of Biotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, Chennai 600119, Tamil Nadu, India
  • 4 Department of Food Processing Technology, School of Agriculture and Biosciences, Karunya Institute of Science and Technology, Karunya Nagar, Coimbatore, 641114, Tamil Nadu, India
  • 5 Department of Chemical Engineering, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, Chennai 600119, Tamil Nadu, India
  • 6 Centre for Materials Engineering and Regenerative Medicine, Bharath Institute of Higher Education and Research, Chennai 600126, Tamil Nadu, India
  • 7 Department of Microbiology, Kamaraj College, Thoothukudi 628003, Tamil Nadu, India
  • 8 Department of Microbiology, Sree Narayana College, Alathur, Palakkad 678682, Kerala, India
  • 9 Department of Transfusion Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605006, India
Polymers (Basel), 2021 Sep 27;13(19).
PMID: 34641118 DOI: 10.3390/polym13193302

Abstract

Polyhydroxyalkanoates (PHAs) are storage granules found in bacteria that are essentially hydroxy fatty acid polyesters. PHA molecules appear in variety of structures, and amongst all types of PHAs, polyhydroxybutyrate (PHB) is used in versatile fields as it is a biodegradable, biocompatible, and ecologically safe thermoplastic. The unique physicochemical characteristics of these PHAs have made them applicable in nanotechnology, tissue engineering, and other biomedical applications. In this review, the optimization, extraction, and characterization of PHAs are described. Their production and application in nanotechnology are also portrayed in this review, and the precise and various production methods of PHA-based nanoparticles, such as emulsion solvent diffusion, nanoprecipitation, and dialysis are discussed. The characterization techniques such as UV-Vis, FTIR, SEM, Zeta Potential, and XRD are also elaborated.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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