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Utilization of Carica papaya latex on coating of SPIONs for dye removal and drug delivery

Samrot AV 1 , Saigeetha S 2 , Mun CY 3 , Abirami S 4 , Purohit K 2 , Cypriyana PJJ 2 Show all authors , Dhas TS 5 , Inbathamizh L 2 , Kumar SS 6

Affiliations 

  • 1 School of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, 42610, Jenjarom, Selangor, Malaysia. antonysamrot@gmail.com
  • 2 Department of Biotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, Rajiv Gandhi Salai, chennai, Tamil Nadu, 600119, India
  • 3 School of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, 42610, Jenjarom, Selangor, Malaysia
  • 4 Department of Microbiology, Kamaraj college, Tiruchendur Road, Thoothukudi, 628003, India
  • 5 Centre for Ocean Research, Earth Science and Technology Cell (ESTC), Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, 600119, India
  • 6 Centre for Materials Engineering and Regenerative Medicine, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, 600073, India. sureshkudsc@gmail.com
Sci Rep, 2021 12 31;11(1):24511.
PMID: 34972829 DOI: 10.1038/s41598-021-03328-2

Abstract

Latex, a milky substance found in a variety of plants which is a natural source of biologically active compounds. In this study, Latex was collected from raw Carica papaya and was characterized using UV-Vis, FTIR and GC-MS analyses. Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) were synthesized, coated with C. papaya latex (PL-Sp) and characterized using UV-Vis, FT-IR, SEM-EDX, XRD, VSM and Zeta potential analyses. SPIONs and latex coated SPIONs (PL-Sp) were used in batch adsorption study for effective removal of Methylene blue (MB) dye, where (PL-Sp) removed MB dye effectively. Further the PL-Sp was used to produce a nanoconjugate loaded with curcumin and it was characterized using UV-Vis spectrophotometer, FT-IR, SEM-EDX, XRD, VSM and Zeta potential. It showed a sustained drug release pattern and also found to have good antibacterial and anticancer activity.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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