Fulltext

Surfactant-mediated synthesis of polyhydroxybutyrate (PHB) nanoparticles for sustained drug delivery

Pachiyappan S 1 , Shanmuganatham Selvanantham D 2 , Kuppa SS 3 , Chandrasekaran S 4 , Samrot AV 5

Affiliations 

  • 1 Department of Chemical Engineering, Sathyabama Institute of Science and Technology, Chennai - 600119, India
  • 2 Center for Waste Management, Sathyabama Institute of Science and Technology, Chennai - 600119, India. dawnsudha@yahoo.com
  • 3 Department of Biotechnology, Shanmugha Arts, Science, Technology & Research Academy, Thanjavur, India
  • 4 Department of Biotechnology, Sathyabama Institute of Science and Technology, Chennai - 600119, India
  • 5 Department of Biomedical Sciences, Faculty of Medicine and Biomedical Sciences, MAHSA University, Jalan SP2, Bandar Saujana Putra, 42810, Jenjarom, Selangor, Malaysia
IET Nanobiotechnol, 2019 Jun;13(4):416-427.
PMID: 31171747 DOI: 10.1049/iet-nbt.2018.5053

Abstract

In this study, polyhydroxybutyrate (PHB) nanoparticles were synthesised following nanoprecipitation method having different solvents and surfactant (Tween 80) concentrations. In this study, PHB nanoparticles were encapsulated with curcumin and subjected for sustained curcumin delivery. Both the curcumin loaded and unloaded PHB nanoparticles were characterised using FTIR, SEM, and AFM. Sizes of the particles were found to be between 60 and 300 nm. The drug encapsulation efficiency and in vitro drug release of the nanoparticles were analysed. Antibacterial activity and anticancer activity were also evaluated. The LC50 values of most of the nanoparticles were found to be between 10 and 20 µg/100 µl, anticancer activity of curcumin loaded PHB nanoparticles were further confirmed by AO/PI staining and mitochondrial depolarisation assay.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications