• 1 Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Malaysia
  • 2 Department of Pharmaceutical Engineering, Faculty of Chemical and Process Engineering Technology, University Malaysia Pahang, Gambang 26300, Malaysia
  • 3 Department of Oral and Maxillofacial Surgery, Collage of Dentistry, University of Anbar, Ramadi, Iraq
  • 4 Department of Chemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, UPM, Serdang 43400, Malaysia
  • 5 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM, Serdang 43300, Malaysia
  • 6 Department of Nutrition Sciences, Faculty of Allied Health Sciences, International Islamic University Malaysia, Kuantan 25200, Malaysia
  • 7 Department of Biomedical sciences, College of Health sciences, QU Health, Qatar University, Doha, Qatar
Molecules, 2020 May 10;25(9).
PMID: 32397633 DOI: 10.3390/molecules25092244


The approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose rather than in multiple doses. The current study aims to improve antioxidant and drug release properties of curcumin loaded gum Arabic-sodium alginate nanoparticles (Cur/ALG-GANPs). The Cur/ALG-GANPs were prepared using the ionotropic gelation technique and further subjected to physico-chemical characterization using attenuated total reflectance-Fourier transform infrared (ATR-FTIR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), size distribution, and transmission electron microscopy (TEM). The size of Cur/ALG-GANPs ranged between 10 ± 0.3 nm and 190 ± 0.1 nm and the zeta potential was -15 ± 0.2 mV. The antioxidant study of Cur/ALG-GANPs exhibited effective radical scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) at concentrations that ranged between 30 and 500µg/mL. Cytotoxicity was performed using MTT assay to measure their potential in inhibiting the cell growth and the result demonstrated a significant anticancer activity of Cur/ALG-GANPs against human liver cancer cells (HepG2) than in colon cancer (HT29), lung cancer (A549) and breast cancer (MCF7) cells. Thus, this study indicates that Cur/ALG-GANPs have promising anticancer properties that might aid in future cancer therapy.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.