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Inhalable Microparticles Embedding Calcium Phosphate Nanoparticles for Heart Targeting: The Formulation Experimental Design

Quarta E 1 , Sonvico F 1 , Bettini R 1 , De Luca C 2 , Dotti A 2 , Catalucci D 3 Show all authors , Iafisco M 4 , Degli Esposti L 4 , Colombo G 5 , Trevisi G 6 , Rekkas DM 7 , Rossi A 1 , Wong TW 8 , Buttini F 1 , Colombo P 1

Affiliations 

  • 1 Food and Drug Department, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy
  • 2 Fin-Ceramica Faenza SPA, Via Granarolo 177/3, 48018 Faenza, Italy
  • 3 IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy
  • 4 Institute of Science and Technology for Ceramics (ISTEC), National Research Council (CNR), Via Granarolo 64, 48018 Faenza, Italy
  • 5 Department of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 17/19, 44121 Ferrara, Italy
  • 6 Institute of Materials for Electronics and Magnetism (IMEM), National Research Council (CNR), Parco Area delle Scienze 37/A, 43124 Parma, Italy
  • 7 Department of Pharmacy, National and Kapodistrian University of Athens, 15784 Zografou, Athens, Greece
  • 8 Non-Destructive Biomedical and Pharmaceutical Research Centre, Smart Manufacturing Research Institute, Universiti Teknologi MARA, Puncak Alam 42300, Selangor, Malaysia
Pharmaceutics, 2021 Nov 01;13(11).
PMID: 34834240 DOI: 10.3390/pharmaceutics13111825

Abstract

Inhalation of Calcium Phosphate nanoparticles (CaPs) has recently unmasked the potential of this nanomedicine for a respiratory lung-to-heart drug delivery targeting the myocardial cells. In this work, we investigated the development of a novel highly respirable dry powder embedding crystalline CaPs. Mannitol was selected as water soluble matrix excipient for constructing respirable dry microparticles by spray drying technique. A Quality by Design approach was applied for understanding the effect of the feed composition and spraying feed rate on typical quality attributes of inhalation powders. The in vitro aerodynamic behaviour of powders was evaluated using a medium resistance device. The inner structure and morphology of generated microparticles were also studied. The 1:4 ratio of CaPs/mannitol led to the generation of hollow microparticles, with the best aerodynamic performance. After microparticle dissolution, the released nanoparticles kept their original size.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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