Affiliations 

  • 1 Department of Chemistry, Kulliyyah of Science, International Islamic University Malaysia Kuantan Campus, Bandar Indera Mahkota, Kuantan 25200, Malaysia
  • 2 Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, Mostra d'Oltremare Pad.20, V.le J.F.Kennedy 54, 80125 Naples, Italy
J Funct Biomater, 2021 Oct 28;12(4).
PMID: 34842715 DOI: 10.3390/jfb12040059

Abstract

The rise of antibiotic resistance has become a major threat to human health and it is spreading globally. It can cause common infectious diseases to be difficult to treat and leads to higher medical costs and increased mortality. Hence, multifunctional polymeric nanofibers with distinctive structures and unique physiochemical properties have emerged as a neo-tool to target biofilm and overcome deadly bacterial infections. This review emphasizes electrospun nanofibers' design criteria and properties that can be utilized to enhance their therapeutic activity for antimicrobial therapy. Also, we present recent progress in designing the surface functionalization of antimicrobial nanofibers with non-antibiotic agents for effective antibacterial therapy. Lastly, we discuss the future trends and remaining challenges for polymeric nanofibers.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.