• 1 Institute of Polymers, Composites and Biomaterials, National research Council of Italy, Naples, ITALY
  • 2 DEPeI-FO, Universidad Autonoma de Mexico, México, Mexico City, MEXICO
  • 3 International Islamic University Malaysia, Kuantan campus, Pahang, Malaysia, Kuala Lumpur, MALAYSIA
  • 4 Chemical Sciences and Materials Technology, National Research Council, Piazzale Aldo Moro, 7, Rome, 00185, ITALY
Nanotechnology, 2017 Oct 23.
PMID: 29058684 DOI: 10.1088/1361-6528/aa9542


Main limitation of conventional antibiotic therapies concerns the low efficacy to bacteria attacks for long treatment times. In this context, the integrated use of electrofluidodynamics (EFDs) - basically electrospinning and electrospraying - may represent an interesting route to design nanostructured platforms with controlled release to prevent the formation of bacterial biofilms in oral implant sites. They allow for the deposition of nanofibres and nanoparticles by different modes - i.e., sequential, simultaneous - for the fabrication of more efficacious systems in terms of degradation protection, pharmacokinetic control and drug distribution to the surrounding tissues. Herein, we will investigate EFDs processing modes and conditions to decorate polycaprolactone (PCL) nanofibres surfaces by chitosan (CS) nano-reservoirs for the administration of Amoxicillin Trihydrate (AMX-DHT) as innovative antibacterial treatment of the periodontal pocket.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.