• 1 Advanced Membrane Technology Research Centre (AMTEC), School of Chemical and Energy Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
  • 2 Department of Chemical and Energy Engineering, Pak-Austria Fachhochschule, Institute of Applied Sciences & Technology (PAF:IAST), Khanpur Road, Mang, Haripur 22650, Pakistan
  • 3 Key Laboratory of Coastal and Wetland Ecosystems, College of Environment & Ecology, Xiamen University, Xiamen, Fujian 361102, China
Surf Interfaces, 2021 Dec;27:101460.
PMID: 34957347 DOI: 10.1016/j.surfin.2021.101460


The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a significant and topmost global health challenge of today. SARS-CoV-2 can propagate through several direct or indirect means resulting in its exponential spread in short times. Consequently, finding new research based real-world and feasible solutions to interrupt the spread of pathogenic microorganisms is indispensable. It has been established that this virus can survive on a variety of available surfaces ranging from a few hours to a few days, which has increased the risk of COVID-19 spread to large populations. Currently, available surface disinfectant chemicals provide only a temporary solution and are not recommended to be used in the long run due to their toxicity and irritation. Apart from the urgent development of vaccine and antiviral drugs, there is also a need to design and develop surface disinfectant antiviral coatings for long-term applications even for new variants. The unique physicochemical properties of graphene-based nanomaterials (GBNs) have been widely investigated for antimicrobial applications. However, the research work for their use in antimicrobial surface coatings is minimal. This perspective enlightens the scope of using GBNs as antimicrobial/antiviral surface coatings to reduce the spread of transmittable microorganisms, precisely, SARS-CoV-2. This study attempts to demonstrate the synergistic effect of GBNs and metallic nanoparticles (MNPs), for their potential antiviral applications in the development of surface disinfectant coatings. Some proposed mechanisms for the antiviral activity of the graphene family against SARS-CoV-2 has also been explained. It is anticipated that this study will potentially lead to new insights and future trends to develop a framework for further investigation on this research area of pivotal importance to minimize the transmission of current and any future viral outbreaks.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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