The prevalence and incidence rate of hypertension among Orang Asli had been increasing due to
modernization and assimilation of outside practices such as intake of high cholesterol food, alcohol, and
smoking. Orang Asli utilize their herbs or plants to treat some illness due to the factor of logistics and the
knowledge on these nature resources since decades ago that is carried out from their ancestors. In this review
paper, hypertension genes of Orang Asli in Peninsular Malaysia and the utilization of ethno-medicinal plants
in reducing the clinical manifestation in hypertension were deliberated. There are quite a number of related
hypertensive genes particularly in renin-angiotensin-aldosterone system (RAAS) playing a pivotal role in
pathogenesis of hypertension. A genome-wide association studies showed potential candidate genes in
hypertension among Orang Asli in Peninsular Malaysia. However there is yet molecular study on these genes
among Orang Asli with their unique genetic profile. Noteworthy information on mechanism of ethnomedicine in treating hypertension are scarce, even the efficacy of modern medicine in treating hypertension
on Orang Asli are rare. Therefore, study on efficacy of ethno-medicine plant by Orang Asli and the
regulation effect on hypertension genes are needed to be further explored and elucidated.
The asymmetric unit of the title complex, [Pd(C15H13FNO)2], contains one half of the mol-ecule with the Pd(II) cation lying on an inversion centre and is coordinated by the bidentate Schiff base anion. The geometry around the cationic Pd(II) centre is distorted square planar, chelated by the imine N- and phenolate O-donor atoms of the two Schiff base ligands. The N- and O-donor atoms of the two ligands are mutually trans, with Pd-N and Pd-O bond lengths of 2.028 (2) and 1.9770 (18) Å, respectively. The fluoro-phenyl ring is tilted away from the coordination plane and makes a dihedral angle of 66.2 (2)° with the phenolate ring. In the crystal, mol-ecules are linked into chains along the [101] direction by weak C-H⋯O hydrogen bonds. Weak π-π inter-actions with centroid-centroid distances of 4.079 (2) Å stack the mol-ecules along c.
Hydroxamic acids [R(CO)N(OH)R'] are flexible compounds for organic and inorganic analyses due to their frailer structures compared to the carboxylic acid. The syntheses and characterization of benzohydroxamic acid (BHA), its CH3-, OCH3-, Cl- para-substituted derivatives and their Cr(III) complexes are reported herein. The metal complexes were synthesized by reacting the hydroxamic acids with chromium(III) chloride hexahydrate in 2:1 molar ratio. The compounds were characterized via melting point, elemental analysis, FTIR, 1H and 13C NMR, TGA, mass spectrometry, molar conductance and UV-Visible. Data analysis suggests that each complex has the Cr(III) center coordinated to the carbonyl and hydroxy oxygen atoms of the hydroxamic acids in bidentate O,O manner and two water molecules to form octahedral geometry. Non-electrolytic behavior of the complexes was shown through their low molar conductivity. Cytotoxicity study against HCT116 and alpha-glucosidase inhibition test revealed that all complexes have higher activity than their parent ligands. Molecular docking study shows that the docking of active complexes is thermodynamically favorable and the inhibition efficiency may depend on the types and the numbers of molecular interactions established in the corresponding stable conformers.