MyMedR

Immunoglobulin levels in various clinical groups of human Brugian filariasis in Malaysia

Sim BK, Mak JW, Kwa BH

Z Parasitenkd, 1983;69(3):371-5.

Quantitation of serum immunoglobulin M, G, A, D and E levels was carried out in Malaysians with Brugia malayi infections. Results showed highly elevated levels of IgM and IgE as well as moderately elevated levels of IgG. These were most significant in patients with tropical pulmonary eosinophilia or elephantiasis. Serum IgE levels were extremely high in microfilaraemic patients (6,060 +/- 3,958 IU ml) probably due to a constant antigenic stimulation by dead and dying microfilariae.

Matched MeSH terms: Pulmonary Eosinophilia/etiology; Pulmonary Eosinophilia/immunology

Fulltext Evaluation of dot immunogold filtration assay (DIGFA) for rapid serodiagnosis of eosinophilic meningitis due to Angio-strongylus cantonensis (Nematoda: Metastrongyloidea)

Eamsobhana P, Prasartvit A, Gan XX, Yong HS

Trop Biomed, 2015 Mar;32(1):121-5.

PMID: 25801261

Angiostrongylus cantonensis is the most frequent cause of eosinophilic meningitis in humans in Thailand and worldwide. Because of difficulty of recovering the Angiostrongylus larvae from infected patients, detection of parasite-specific antibodies is used to support clinical diagnosis. This study tested serum samples from eosinophilic meningitis patients and individuals at risk of infection with A. cantonensis to evaluate a recently developed simple and rapid dot-immunogold filtration assay (DIGFA) for detection of specific antibodies against A. cantonensis. Purified 31-kDa glycoprotein of A. cantonensis and protein A colloidal gold conjugate were employed to detect the 31-kDa anti-A. cantonensis antibody in patients sera from the parasite endemic areas of northeast Thailand. The results were compared with those obtained by dot-blot enzyme-linked immunosorbent assay (ELISA) with 31-kDa A. cantonensis antigen. The overall positivity rate of DIGFA and dot-blot ELISA for A. cantonensis infection in 98 clinically diagnosed cases from three highly endemic districts in Khon Kaen province were 39.79% and 37.75%, respectively. Among 86 sera of subjects at risk of infection with A. cantonensis, 24.41% were positive by DIGFA and 23.25% by dot-blot ELISA. There were good correlation between the visual grading of DIGFA and dot-blot ELISA in both groups of defined sera. DIGFA is as sensitive and specific as dot-blot ELISA for confirming eosinophilic meningitis due to A. cantonensis infection, with advantages of simplicity, rapidity and without the use of specific and expensive equipment, and can be used in field settings.

Matched MeSH terms: Eosinophilia/diagnosis*

Seropositivity and risk factors of Toxocara canis infection in adult asthmatic patients

Rouhani-Rankouhi SZ, Kow KS, Liam CK, Lau YL

Trop Biomed, 2020 Sep 01;37(3):599-608.

PMID: 33612775 DOI: 10.47665/tb.37.3.599

This cross-sectional study involving 86 adult asthmatic patients aimed to determine the relationship between Toxocara seropositivity and severity of asthma in adult asthmatics and investigate the risk factors for Toxocara infection. In all cases, T. canis IgG level was measured using an anti-Toxocara IgG enzyme-linked immunosorbent assay kit. Total serum IgE and eosinophil count were also determined. The anti-Toxocara IgG seropositivity was 68.6% among asthmatic patients. There were no statistically significant associations between Toxocara seroprevalence and other risk factors, clinical symptoms of asthma and high level of total serum IgE and eosinophilia. Pet ownership could be an important risk factor for Toxocariasis. Having a pet at home and wheezing were significantly associated with Toxocara seropositivity in adult asthmatic patients.

Matched MeSH terms: Eosinophilia

Imported eosinophilic fever with myositis: A diagnostic challenge

Camprubí D, Rodriguez-Valero N, Losada I, Grau-Junyent JM, Muñoz J

Travel Med Infect Dis, 2018 05 23;24:16.

PMID: 29802894 DOI: 10.1016/j.tmaid.2018.05.009

Matched MeSH terms: Eosinophilia/diagnosis*; Eosinophilia/parasitology

Filarial antibodies and eosinophilia in human subjects in an endemic area

Wong MM, Guest MF

Trans R Soc Trop Med Hyg, 1969;63(6):796-800.

PMID: 5368008

Matched MeSH terms: Eosinophilia/etiology*

Tropical pulmonary eosinophilia [duplicate2]

Pallister RA

Trans R Soc Trop Med Hyg, 1951;44:756.

DOI: 10.1016/0035-9203(51)90012-0

Matched MeSH terms: Eosinophilia

Hypereosinophilia responding to empirical antihelminthic treatment

Loh KY, Lee XE

Southeast Asian J. Trop. Med. Public Health, 2010 Nov;41(6):1322-3.

PMID: 21329305

We report a 20-year-old college student presents with bilateral ankle edema associated with hypereosinophilia following a history of traveling in a rural area. Physical examinations and investigations failed to diagnose any underlying cause. She was treated with antihelminth medication and the edema subsided within a week and the eosinophil counts normalized within two weeks.

Matched MeSH terms: Eosinophilia/complications; Eosinophilia/diagnosis; Eosinophilia/drug therapy*

Fulltext Distribution of anti-Toxoplasma gondii antibodies among Orang Asli (aborigines) in Peninsular Malaysia

Hakim SL, Radzan T, Nazma M

Southeast Asian J. Trop. Med. Public Health, 1994 Sep;25(3):485-9.

PMID: 7777912

The distribution of anti-toxoplasma antibodies among the aborigines in Malaysia and its association with other soil transmitted infections and eosinophilia were studied. A total of 415 serum samples were collected and tested by IFA test. Overall prevalence was 10.6%, lower than previously reported. The antibody titers showed a unimodal distribution peaking at 1:8 dilution. There was a higher proportion of high antibody titer (> 1:128) in the adult compared to the children with no significant difference in prevalence rate by sex. The pattern of infection does not differ from other soil transmitted infections and there was no association between raised Toxoplasma antibodies with eosinophilia.

Matched MeSH terms: Eosinophilia/complications; Eosinophilia/epidemiology

Fulltext Hematological changes in subperiodic Brugia malayi infection of the leaf-monkey, Presbytis cristata

Choong MF, Mak JW

Southeast Asian J. Trop. Med. Public Health, 1991 Jun;22(2):168-70.

PMID: 1948274

Hematological changes were monitored in the leaf-monkey, Presbytis cristata, infected experimentally with 200 subperiodic Brugia malayi infective larvae. Prepatent periods were 54-86 days and peak microfilarial geometric mean counts (GMCs) were 1324 per ml blood. Total leukocyte and differential counts were measured at pre-infection, and then at weakly intervals before and during patency. Blood eosinophil level increased to about thrice the initial level at 3 weeks post-infection and this was maintained for the next 13 weeks before it started to rise again, increasing to more than 5 times the initial level at 20 weeks post-infection. The observed pattern of eosinophilia is probably related to the level of microfilaremia and the destruction of microfilariae in the spleen. There was no significant change in the total leukocyte counts during the period of observation.

Matched MeSH terms: Eosinophilia/blood

Filariasis due to Brugia malayi in west Malayasia. I. Clinical, laboratory, and parasitological aspects

Dondero TJ, Ramachandran CP, Bin Yusoff O

Southeast Asian J. Trop. Med. Public Health, 1971 Dec;2(4):503-15.

PMID: 5144151

Matched MeSH terms: Eosinophilia/etiology

Filariasis due to Brugia malayi in West Malaysia. II. Skin test aspects

Dondero TJ, Ramachandran CP

Southeast Asian J. Trop. Med. Public Health, 1972 Mar;3(1):25-30.

PMID: 5028861

Matched MeSH terms: Eosinophilia/complications

Fulltext Kimura's disease of the parotid: A complete clinical-radiological-pathology report

Ragu R, Eng JY, Azlina AR

Med J Malaysia, 2014 Aug;69(4):199-201.

PMID: 25500854

Kimura's disease is rare chronic inflammatory disease with a distinct clinicopathological entity. It has three major components; inflammatory, vascular and fibrosis. It has to be considered as a differential diagnosis in young patient presenting with head and neck swelling. Although of unknown aetiology many hypothesis has been postulated. Inflammation is the most prominent and predominating characteristic in this disease. Although reported to be predominant in Asian literature regarding this disease is scanty. We report a complete clinical-radiological and pathological picture of this disease.

Matched MeSH terms: Angiolymphoid Hyperplasia with Eosinophilia

Fulltext ANCA-associated vasculitis - revisited, and its association with autoimmune thyroid disease

Lai Y, Nik Yahya NH, Ong SG

Med J Malaysia, 2014 Apr;69(2):98-100.

PMID: 25241822

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are a group of uncommon diseases. Given its rarity and multisystem clinical presentation which are usually serious and potentially fatal, prompt recognition and early treatment are of utmost importance. We report a case of AAV that presented with digital infarcts, cutaneous vasculitis, rapidly progressive glomerulonephritis, mononeuritis multiplex, eosinophilia and positive myeloperoxidase (MPO)-ANCA antibody. Apart from renal damage, there was complete recovery in other systems following intravenous cyclophosphamide and high-dose glucocorticoids albeit the response was delayed. This response obviates the need for second-line therapy with newer agent such as rituximab (anti-CD20 monoclonal antibody). We would also like to highlight that this is the first case of AAV that is associated with autoimmune thyroid disease to be reported from Malaysia.

Matched MeSH terms: Eosinophilia

Fulltext Kimura's disease in Malay patients

Shahrul H, Baharudin A, Effat O

Med J Malaysia, 2007 Aug;62(3):263-4.

PMID: 18246925 MyJurnal

Kimura's Disease (KD) is an uncommon, chronic inflammatory disorder of unknown etiology which is endemic in Orientals. It is characterized by painless, large solitary or multiple nodules in subcutis of head and neck region or the major salivary glands, associated with regional lymphadenopathy, blood eosinophilia and elevated IgE levels. Its treatment ranging from conservative observation in asymptomatic patient to surgical resection of the mass, corticotherapy and irradiation therapy for the symptomatic ones.

Matched MeSH terms: Angiolymphoid Hyperplasia with Eosinophilia/diagnosis; Angiolymphoid Hyperplasia with Eosinophilia/physiopathology*; Angiolymphoid Hyperplasia with Eosinophilia/therapy

Fulltext Kimura's disease: an unusual cause of cervical tumor

Asma A, Maizaton AA

Med J Malaysia, 2005 Aug;60(3):373-6.

PMID: 16379197

Kimura's disease (KD) is an angiolymphoid proliferative disease of soft tissue with peripheral blood eosinophilia and elevated serum immunoglobulin (Ig) E. The treatment options range from conservative observation for the asymptomatic patient to surgical excision, steroid therapy and radiotherapy for symptomatic patients. Surgical excision is the most common diagnostic measure and is the treatment of choice. A case of KD in a 13-year-old Malay girl is presented. Clinically there was painless right jugular digastric mass measuring 3cm by 3cm. Her blood investigation showed pronounced eosinophilia. She underwent excision biopsy uneventfully. The biopsy from the swelling showed reactive follicular hyperplasic with prominent eosinophilia. There was no evidence of malignant change. Postoperatively after 3 years follow up, she was asymptomatic and no signs of tumor recurrence.

Matched MeSH terms: Angiolymphoid Hyperplasia with Eosinophilia/complications*; Angiolymphoid Hyperplasia with Eosinophilia/pathology; Eosinophilia/etiology; Eosinophilia/pathology

Eosinophilic gastroenteritis: Clinical profiles and treatment outcomes, a retrospective study of 18 adult patients in a Singapore Tertiary Hospital

Wong GW, Lim KH, Wan WK, Low SC, Kong SC

Med J Malaysia, 2015 08;70(4):232-7.

PMID: 26358020

BACKGROUND: Eosinophilic gastroenteritis (EG) can mimic symptoms of common gastrointestinal (GI) disorders but responds well to appropriate treatment. Accurate diagnosis is central to effective management. Data on EG in Southeast Asia is lacking. We aim to describe the clinical profiles and treatment outcomes of adult patients with EG in a Singapore Tertiary Hospital.

MATERIALS AND METHODS: This retrospective study involved archival search of patients with GI biopsies that showed eosinophilic infiltration from January 2004 to December 2012. Patients' clinical data from computerised hospital records and clinical notes was reviewed. Diagnostic criteria for EG included presence of GI symptoms with more than 30 eosinophils/high power field on GI biopsies. Patients with secondary causes for eosinophilia were excluded.

RESULTS: Eighteen patients with EG were identified (mean age 52 years; male/female: 11/7). Fifteen patients (83%) had peripheral blood eosinophilia. Seven patients (39%) had atopic conditions. Most common symptoms were diarrhoea and abdominal pain. Small intestine was the most common site involved. Endoscopic finding was non-specific. Ten patients were treated with corticosteroids (nine prednisolone, one budesonide): eight patients (89%) responded clinically to prednisolone but four patients (50%) relapsed following tapering-off of prednisolone and required maintenance dose. One patient each responded to diet elimination and montelukast respectively. Half of the remaining six patients who were treated with proton-pump inhibitors, antispasmodic or antidiarrheal agents still remained symptomatic.

CONCLUSION: Prednisolone is an effective treatment though relapses are common. Small intestine is most commonly involved. EG should be considered in the evaluation of unexplained chronic recurrent GI symptoms.

Matched MeSH terms: Eosinophilia

Fulltext Kimura's Disease: Diagnostic Challenge and Treatment Modalities

Sia KJ, Kong CK, Tan TY, Tang IP

Med J Malaysia, 2014 Dec;69(6):281-3.

PMID: 25934961

CASE REPORT: Five cases of Kimura's disease had been treated in our centre from year 2003 to 2010. All cases were presented with head and neck mass with cervical lymphadenopathy. Surgical excision was performed for all cases. Definite diagnosis was made by histopathological examination of the resected specimens. One out of five cases developed tumour recurrence four years after resection.

CONCLUSION: Surgical excision is our choice of treatment because the outcome is immediate and definite tissue diagnosis is feasible after resection. Oral corticosteroid could be considered as an option in advanced disease. However, tumour recurrence is common after cessation of steroid therapy.

Matched MeSH terms: Angiolymphoid Hyperplasia with Eosinophilia

Fulltext A study of 31 patients with easy bruising from University Hospital, Kuala Lumpur

Chin NS, Koong PL

Med J Malaysia, 1990 Dec;45(4):325-8.

PMID: 2152054

Thirty one patients were investigated for the main complaint of easy bruising. These patients had normal platelet count with no past history of immune thrombocytopenia or systemic disorders known to predispose to bruising and a negative drug history. The evaluation of these patients included clinical review (history and physical examination) plus coagulation tests consisting of bleeding time, prothrombin time, partial thromboplastin time, thrombin time, fibrinogen level, FXIII screen and platelet functions test. Seven of the paediatric patients had acquired platelet dysfunction with eosinophilia (APDE). In 17 (94.4%) of the 18 adult patients no abnormality was demonstrated. Hence APDE was the commonest cause of easy bruising in children while the haemostatic defect contributing to easy bruising in adults remained unknown.

Matched MeSH terms: Eosinophilia/complications

Fulltext Acquired platelet dysfunction with eosinophilia (APDE): an underrecognised condition

Ramanathan M, Duraisamy G

Med J Malaysia, 1987 Mar;42(1):53-5.

PMID: 3431503

We present three cases of Acquired Platelet Dysfunction with Eosinophilia (APDE). The importance of recognising this benign condition, which usually does not require any specific therapy, is stressed to avoid the pitfalls of diagnosing more serious bleeding disorders in children presenting with ecchymosis.

Matched MeSH terms: Eosinophilia/blood*

Fulltext Cutaneous drug eruptions

Adam BA

Med J Malaysia, 1982 Jun;37(2):110-3.

PMID: 6215559

Patients attending a referral Skin Clinic were studied to identify the spectrum of drug eruptions and the offending drugs. There were 51 patients with an incidence of five per thousand and equal sex incidence. Though the pattern of eruption was broadly similar to other reports, unusual reactions were observed. In addition to the skin manifestation, fever and lymphadenopathy were present in most patients. Raised erythrocyte sedimentation rate and eosinopoenia were commonly observed. Clinical acumen and the list of drugs ingested are still the best clues to the diagnosis ofdrug eruption.
Study site: Skin clinic, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia

Matched MeSH terms: Eosinophilia/complications

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