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Fulltext Dental Home Visits for Caries Prevention Among Preschool Children: Protocol for a Cost-Effectiveness Analysis on a Randomized Control Trial

Andiesta NS, Hamid MA, Lee K, Pau A

JMIR Res Protoc, 2018 Jun 06;7(6):e10053.
PMID: 29875086 DOI: 10.2196/10053

BACKGROUND: In 2012, nearly 4000 children in Malaysia were referred to hospital pediatric dental services due to dental caries. Recent research has reported the effectiveness of dental home visits in preventing caries development in young children. Dental home visits (DHVs) are described as an ongoing relationship between the dentist and their patients, providing all aspects of a preventive oral health care program in the presence of the parents at home.
OBJECTIVE: The objective of this study is to evaluate the cost-effectiveness of dental home visits and oral health information, in the form of educational leaflets, in preventing new caries development in young children, compared to those receiving only educational leaflets over a period of two years. Cost-effectiveness analysis will be used to evaluate the cost-effectiveness of dental home visits.
METHODS: This is a collaborative project with the Oral Health Division of the Ministry of Health Malaysia. The Oral Health Division will provide access to a subsample from the National Oral Health of Preschoolers Survey which was carried out in 2015. The population of interest is children aged 5 and 6 years from kindergartens in the Selangor state of Malaysia. The study adopted a societal perspective for cost-effectiveness analysis and all types of resources that are of value to society will be included in analyzing the costs; such as cost to the patient, cost to the provider or institution, and indirect costs because of loss of productivity.
RESULTS: The trial has been approved by the International Medical University Malaysia's Joint Research and Ethics Committee (Project ID: IMU R157-2014 [File III - 2016]). This trial is currently recruiting participants.
CONCLUSIONS: The number of young children in Malaysia who have been referred to the hospital children's dentistry service for severe caries is disturbing. The cost of dental treatment in young children is high due to the severity of the caries which require an aggressive treatment, and the need for general anesthesia or sedation. This study will provide information on the cost and effectiveness of DHVs in caries prevention of young children in Malaysia.
REGISTERED REPORT IDENTIFIER: RR1-10.2196/10053.

Matched MeSH terms: Dental Caries
Isolation and characterization of Enterococcus faecium DSM 20477 with ability to secrete antimicrobial substance for the inhibition of oral pathogen Streptococcus mutans UKMCC 1019

Ng ZJ, Zarin MA, Lee CK, Phapugrangkul P, Tan JS

Arch Oral Biol, 2020 Feb;110:104617.
PMID: 31794906 DOI: 10.1016/j.archoralbio.2019.104617

Streptococcus mutans and Candida albicans are the main oral pathogens which contribute to dental caries that affects all ages of human being.
OBJECTIVES: This study focuses on the potential of crude cell free supernatant (CCFS) from lactic acid bacteria (LAB) to inhibit of the growth of S. mutans UKMCC 1019.
DESIGN: A total of 61 CCFS from LAB strains were screened for their inhibitory ability against S. mutans UKMCC 1019 by broth microdilution method. The selected LAB with highest antimicrobial activity was identified and its CCFS was characterized for pH stability, temperature tolerance, enzyme sensitivity, metabolism of carbohydrates, enzymatic activities and antimicrobial activity against S. mutans UKMCC 1019 and C. albicans UKMCC 3001 by well diffusion assay. The effect of CCFS on cell structure of S. mutans UKMCC 1019 was observed under transmission electron microscopy (TEM).
RESULTS: The CCFS from isolate CC2 from Kimchi showed the highest inhibition against S. mutans UKMCC 1019, which was 76.46 % or 4406.08 mm2/mL and it was identified to be most closely related to Enterococcus faecium DSM 20477 based on 16 s rRNA sequencing. The CCFS of E. faecium DSM 20477 had high tolerance to acidic and alkaline environment as well as high temperature. It also shows high antifungal activities against C. albicans UKMCC 3001 with 2362.56 mm2/mL. Under TEM, the cell walls and the cytoplasm membrane of S. mutans UKMCC 1019 were disrupted by the antimicrobial substance, causing cell lysis.
CONCLUSIONS: Hence, the CCFS from E. faecium DSM 20477 is a potential bacteriocin in future for the treatment of dental caries.

Matched MeSH terms: Dental Caries
Dental condition in Malaya

Tratman EK

Journal of the Malaya Branch of the British Medical Association, 1940;4:184-90.

Matched MeSH terms: Dental Caries
Fulltext Knowledge, attitude and practice on preventive dentistry among senior dental students in Yemen

Mohammed Ali Mohammed Al-Wesabi, Zaleha Md Isa

Int J Public Health Res, 2015;5(1):560-568.
MyJurnal

Introduction There is a strong and increased worldwide interest on the aspects of
prevention of oral disease and oral health promotion in dental education.
However, some studies imply that dental students are not knowledgeable
enough in this issue. This study aimed to evaluate the knowledge of, attitude
towards and practice on preventive dentistry among senior dental students in
Yemen.

Methods Self-administered questionnaires were distributed among senior dental
students in six dental schools in Yemen. The questionnaire obtained personal
information, and questions about knowledge on preventive dental care,
attitudes towards and practice on preventive dentistry.

Results Among 346 students who filled the questionnaire, a total of 91.6% has good
knowledge about fissure sealant effectiveness, only 34.7% knows about the
importance of fluoride toothpaste compared to brushing technique in
preventing caries, with significant gender difference (p=0.005). Odds of good
knowledge among non-Qat chewers was 1.9 (95%CI: 1.26-4.42).
Multivariable regression analysis indicated that female gender was associated
with higher positive attitudes (OR: 2.03, 95%CI:1.21-3.36,p=0.007).
Attitudes were significantly associated with Qat chewing (OR = 1.95,
95%CI: 1.04-3.66, p=0.03), type of university (OR = 0.59, 95%CI: 0.36-0.94,
p=0.02), and mothers' level of education (OR = 1.91, 95%CI: 1.05-3.47,
p=0.03). There was a high percentage of competency in practicing preventive
measures among students (80.9%).

Conclusions Dental education should emphasize the overall aspects of preventive dentistry
with early exposure of preventive dental training in order to improve
students' knowledge and attitudes and consequently practice on preventive
care.

Matched MeSH terms: Dental Caries
Fulltext In Vitro Antibacterial Activity of Galls of Quercus infectoria Olivier against Oral Pathogens

Basri DF, Tan LS, Shafiei Z, Zin NM

Evid Based Complement Alternat Med, 2012;2012:632796.
PMID: 22203875 DOI: 10.1155/2012/632796

The galls of Quercus infectoria are commonly used in Malay traditional medicine to treat wound infections after childbirth. In India, they are employed traditionally as dental applications such as that in treatment of toothache and gingivitis. The aim of the present study was to evaluate the antibacterial activity of galls of Quercus infectoria Olivier against oral bacteria which are known to cause dental caries and periodontitis. Methanol and acetone extracts were screened against two Gram-positive bacteria (Streptococcus mutans ATCC 25175 and Streptococcus salivarius ATCC 13419) and two Gram-negative bacteria (Porphyromonas gingivalis ATCC 33277 and Fusobacterium nucleatum ATCC 25586). The screening test of antibacterial activity was performed using agar-well diffusion method. Subsequently, minimum inhibitory concentration (MIC) was determined by using twofold serial microdilution method at a concentration ranging between 0.01 mg/mL and 5 mg/mL. Minimum bactericidal concentration (MBC) was obtained by subculturing microtiter wells which showed no changes in colour of the indicator after incubation. Both extracts showed inhibition zones which did not differ significantly (P < 0.05) against each tested bacteria. Among all tested bacteria, S. salivarius was the most susceptible. The MIC ranges for methanol and acetone extracts were the same, between 0.16 and 0.63 mg/mL. The MBC value, for methanol and acetone extracts, was in the ranges 0.31-1.25 mg/mL and 0.31-2.50 mg/mL, respectively. Both extracts of Q. infectoria galls exhibited similar antibacterial activity against oral pathogens. Thus, the galls may be considered as effective phytotherapeutic agents for the prevention of oral pathogens.

Matched MeSH terms: Dental Caries
Fulltext Proliferative activity of cells from remaining dental pulp in response to treatment with dental materials

Lutfi AN, Kannan TP, Fazliah MN, Jamaruddin MA, Saidi J

Aust Dent J, 2010 Mar;55(1):79-85.
PMID: 20415916 DOI: 10.1111/j.1834-7819.2009.01185.x

The biological examination of pulp injury, repair events and response of dental pulp stem cells to dental restorative materials is important to accomplish restorative treatment, especially to commonly used dental materials in paediatric dentistry, such as glass ionomer cement (GIC) and calcium hydroxide (Ca(OH)(2)) lining cement.

Matched MeSH terms: Dental Caries/therapy
Fulltext Scedosporium apiospermum: A Rare Cause of Aggressive Orbital Apex Syndrome

Loh UL, Tai PY, Hussein A, A Qamarruddin F

Cureus, 2018 Dec 17;10(12):e3743.
PMID: 30800553 DOI: 10.7759/cureus.3743

Orbital apex syndrome (OAS) is a localized orbital cellulitis at the orbital apex that can cause vision loss from optic neuropathy and ophthalmoplegia involving multiple cranial nerves. Herein, we report a rare and rapidly progressive case of OAS secondary to fungal pansinusitis caused by Scedosporiumapiospermum in an immunocompromised patient following the extraction of abscessed teeth. A 48-year-old man with diabetes mellitus who had failed to adhere to his treatment presented with complaints of a right-sided headache and toothache for two weeks, with nausea and vomiting for two days prior to presentation. The patient was treated for septic shock secondary to the dental abscesses. Non-contrast brain computed tomography (CT) showed no significant intracranial abnormalities other than pansinusitis. Four days later, dental extraction was performed. The patient reported progressive painless blurring of the vision in his right eye following the dental extractions and was referred to the ophthalmology department. Subsequent examinations revealed decreased optic nerve function and ophthalmoplegia in his right eye and dental caries in the upper molars, with a mucopurulent discharge from the right sphenoid region. The clinical diagnosis was OAS. Pus near the orbital apex was drained surgically. Methicillin-resistant Staphylococcus aureus was isolated from the pus and a nasal swab. Tissue culture from the septal wall yielded S.apiospermum. The patient's condition deteriorated, despite intensive antibiotic and antifungal treatment and repeated surgical debridement. The disease progressed rapidly to his left eye. Sixty-seven days after the inital presentation, his visual acuity (VA) of both eyes was classified as no perception of light (NPL). The patient discharged himself from the hospital (at own risk discharge) and subsequently failed to attend a scheduled appointment in the ophthalmology clinic. If immunocompromised patients present with OAS, fungal infections should be ruled out. Prompt and aggressive treatment using a multidisciplinary approach is mandatory in cases of potentially life-threatening and vision-threatening fungal infections.

Matched MeSH terms: Dental Caries