MyMedR

Displaying publications 21 - 24 of 24 in total

Abstract:

Sort:

Genetic divergence and evolutionary relationship in Fejervarya cancrivora from Indonesia and other Asian countries inferred from allozyme and MtDNA sequence analyses

Kurniawan N, Islam MM, Djong TH, Igawa T, Daicus MB, Yong HS, et al.

Zoolog Sci, 2010 Mar;27(3):222-33.
PMID: 20192690 DOI: 10.2108/zsj.27.222

To elucidate genetic divergence and evolutionary relationship in Fejervarya cancrivora from Indonesia and other Asian countries, allozyme and molecular analyses were carried out using 131 frogs collected from 24 populations in Indonesia, Thailand, Bangladesh, Malaysia, and the Philippines. In the allozymic survey, seventeen enzymatic loci were examined for 92 frogs from eight representative localities. The results showed that F. cancrivora is subdivided into two main groups, the mangrove type and the large- plus Pelabuhan ratu types. The average Nel's genetic distance between the two groups was 0.535. Molecular phylogenetic trees based on nucleotide sequences of the 16S rRNA and Cyt b genes and constructed with the ML, MP, NJ, and BI methods also showed that the individuals of F. cancrivora analyzed comprised two clades, the mangrove type and the large plus Pelabuhan ratu / Sulawesi types, the latter further split into two subclades, the large type and the Pelabuhan ratu / Sulawesi type. The geographical distribution of individuals of the three F. cancrivora types was examined. Ten Individuals from Bangladesh, Thailand, and the Philippines represented the mangrove type; 34 Individuals from Malaysia and Indonesia represented the large type; and 11 individuals from Indonesia represented the Pelabuhan ratu / Sulawesi type. Average sequence divergences among the three types were 5.78-10.22% for the 16S and 12.88-16.38% for Cyt b. Our results suggest that each of the three types can be regarded as a distinct species.
Fulltext Mechanistic Approaches of Internalization, Subcellular Trafficking, and Cytotoxicity of Nanoparticles for Targeting the Small Intestine

Madni A, Rehman S, Sultan H, Khan MM, Ahmad F, Raza MR, et al.

AAPS PharmSciTech, 2020 Nov 22;22(1):3.
PMID: 33221968 DOI: 10.1208/s12249-020-01873-z

Targeting the small intestine employing nanotechnology has proved to be a more effective way for site-specific drug delivery. The drug targeting to the small intestine can be achieved via nanoparticles for its optimum bioavailability within the systemic circulation. The small intestine is a remarkable candidate for localized drug delivery. The intestine has its unique properties. It has a less harsh environment than the stomach, provides comparatively more retention time, and possesses a greater surface area than other parts of the gastrointestinal tract. This review focuses on elaborating the intestinal barriers and approaches to overcome these barriers for internalizing nanoparticles and adopting different cellular trafficking pathways. We have discussed various factors that contribute to nanocarriers' cellular uptake, including their surface chemistry, surface morphology, and functionalization of nanoparticles. Furthermore, the fate of nanoparticles after their uptake at cellular and subcellular levels is also briefly explained. Finally, we have delineated the strategies that are adopted to determine the cytotoxicity of nanoparticles.
Prosthetic Rehabilitation of Microstomia Patients: A Systematic Review of Published Case Reports and Case Series

Patil S, Raj AT, Sarode SC, Sarode GS, Menon RK, Bhandi S, et al.

J Contemp Dent Pract, 2019 Apr 01;20(4):508-515.
PMID: 31308286

STATEMENT OF PROBLEM: Prosthetic techniques commonly employed for the rehabilitation of edentulous patients might not be adequate in the treatment of patients with microstomia.
PURPOSE: The purpose of this paper is to systematically review all the prosthetic techniques that have been used in the oral rehabilitation of patients with microstomia.
MATERIALS AND METHODS: Data sources, including PubMed, Google Scholar, SCOPUS and Web of Science, were searched for case reports and case series published through September 2017. Three investigators reviewed and verified the extracted data. Only case reports and case series on prosthetic rehabilitation in microstomia patients published in the English language were considered eligible.
RESULTS: A total of 212 records were identified from the database search. Forty duplicate records were removed. The remaining 172 articles were assessed for eligibility, and 139 articles were removed because they did not satisfy the inclusion criteria. A total of 34 cases (including 32 case reports and 1 case series) were finally included in the qualitative analysis. The review revealed the use of a modified impression technique with flexible and sectional trays to record impressions in patients with microstomia. Modified forms of oral prostheses ranging from sectional, flexible, collapsible and hinged dentures to implant-supported prosthesis were fabricated to overcome the limited mouth opening. The success of the prosthetic technique primarily depended on the extent of the microstomia and the nature of the cause of the microstomia.
CONCLUSION: Even though the patient acceptance of the prosthetic techniques summarized in the systematic review were high, long-term success rates for each option could not be assessed because of the short follow-up time in most of the included case reports and series.
Spatiotemporal changes in future precipitation of Afghanistan for shared socioeconomic pathways

Rahimi ST, Safari Z, Shahid S, Hayet Khan MM, Ali Z, Ziarh GF, et al.

Heliyon, 2024 Apr 15;10(7):e28433.
PMID: 38571592 DOI: 10.1016/j.heliyon.2024.e28433

Global warming induces spatially heterogeneous changes in precipitation patterns, highlighting the need to assess these changes at regional scales. This assessment is particularly critical for Afghanistan, where agriculture serves as the primary livelihood for the population. New global climate model (GCM) simulations have recently been released for the recently established shared socioeconomic pathways (SSPs). This requires evaluating projected precipitation changes under these new scenarios and subsequent policy updates. This research employed six GCMs from the CMIP6 to project spatial and temporal precipitation changes across Afghanistan under all SSPs, including SSP1-1.9, SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5. The employed GCMs were bias-corrected using the Global Precipitation Climatological Center's (GPCC) monthly gridded precipitation data with a 1.0° spatial resolution. Subsequently, the climate change factor was calculated to assess precipitation changes for both the near future (2020-2059) and the distant future (2060-2099). The bias-corrected projections' multi-model ensemble (MME) revealed increased precipitation across most of Afghanistan for SSPs with higher emissions scenarios. The bias-corrected simulations showed a substantial increase in summer precipitation of around 50%, projected under SSP1-1.9 in the southwestern region, while a decline of over 50% is projected in the northwestern region until 2100. The annual precipitation in the northwest region was projected to increase up to 15% for SSP1-2.6. SSP2-4.5 showed a projected annual precipitation increase of around 20% in the southwestern and certain eastern regions in the far future. Furthermore, a substantial rise of approximately 50% in summer precipitation under SSP3-7.0 is expected in the central and western regions in the far future. However, it is crucial to note that the projected changes exhibit considerable uncertainty among different GCMs.