Displaying publications 21 - 40 of 55 in total

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  1. Muazu Musa R, P P Abdul Majeed A, Taha Z, Chang SW, Ab Nasir AF, Abdullah MR
    PLoS One, 2019;14(1):e0209638.
    PMID: 30605456 DOI: 10.1371/journal.pone.0209638
    k-nearest neighbour (k-NN) has been shown to be an effective learning algorithm for classification and prediction. However, the application of k-NN for prediction and classification in specific sport is still in its infancy. The present study classified and predicted high and low potential archers from a set of physical fitness variables trained on a variation of k-NN algorithms and logistic regression. 50 youth archers with the mean age and standard deviation of (17.0 ± 0.56) years drawn from various archery programmes completed a one end archery shooting score test. Standard fitness measurements of the handgrip, vertical jump, standing broad jump, static balance, upper muscle strength and the core muscle strength were conducted. Multiple linear regression was utilised to ascertain the significant variables that affect the shooting score. It was demonstrated from the analysis that core muscle strength and vertical jump were statistically significant. Hierarchical agglomerative cluster analysis (HACA) was used to cluster the archers based on the significant variables identified. k-NN model variations, i.e., fine, medium, coarse, cosine, cubic and weighted functions as well as logistic regression, were trained based on the significant performance variables. The HACA clustered the archers into high potential archers (HPA) and low potential archers (LPA). The weighted k-NN outperformed all the tested models at itdemonstrated reasonably good classification on the evaluated indicators with an accuracy of 82.5 ± 4.75% for the prediction of the HPA and the LPA. Moreover, the performance of the classifiers was further investigated against fresh data, which also indicates the efficacy of the weighted k-NN model. These findings could be valuable to coaches and sports managers to recognise high potential archers from a combination of the selected few physical fitness performance indicators identified which would subsequently save cost, time and energy for a talent identification programme.
    Matched MeSH terms: Muscle, Skeletal/physiology
  2. Sado F, Yap HJ, Ghazilla RAR, Ahmad N
    PLoS One, 2018;13(7):e0200193.
    PMID: 30001415 DOI: 10.1371/journal.pone.0200193
    Prolong walking is a notable risk factor for work-related lower-limb disorders (WRLLD) in industries such as agriculture, construction, service profession, healthcare and retail works. It is one of the common causes of lower limb fatigue or muscular exhaustion leading to poor balance and fall. Exoskeleton technology is seen as a modern strategy to assist worker's in these professions to minimize or eliminate the risk of WRLLDs. Exoskeleton has potentials to benefit workers in prolong walking (amongst others) by augmenting their strength, increasing their endurance, and minimizing high muscular activation, resulting in overall work efficiency and productivity. Controlling exoskeleton to achieve this purpose for able-bodied personnel without impeding their natural movement is, however, challenging. In this study, we propose a control strategy that integrates a Dual Unscented Kalman Filter (DUKF) for trajectory generation/prediction of the spatio-temporal features of human walking (i.e. joint position, and velocity, and acceleration) and an impedance cum supervisory controller to enable the exoskeleton to follow this trajectory to synchronize with the human walking. Experiment is conducted with four subjects carrying a load and walking at their normal speed- a typical scenario in industries. EMG signals taken at two muscles: Right Vastus Intermedius (on the thigh) and Right Gastrocnemius (on the calf) indicated reduction in muscular activation during the experiment. The results also show the ability of the control system to predict spatio-temporal features of the pilots' walking and to enable the exoskeleton to move in concert with the pilot.
    Matched MeSH terms: Muscle, Skeletal/physiology
  3. Abuajwa B, Hamlin M, Hafiz E, Razman R
    PeerJ, 2022;10:e14049.
    PMID: 36193438 DOI: 10.7717/peerj.14049
    BACKGROUND: The intensity of strength training exercise is generally regarded to be the most essential element in developing muscle strength and power. The exercise intensity of strength training is known as one-repetition maximum (1RM). Velocity-based training (VBT) has been proposed as a different approach for determining training intensity. VBT relies on the use of linear position transducers and inertial measurement units, providing real-time feedback to objectively adjust the exercise intensity based on an athlete's velocity zone.

    METHODS: This study investigated the effects of two different training interventions based on individualized load velocity profiles (LVP) on maximal bench press strength (i.e., 1RM), maximum throwing velocity (TV), and skeletal muscle mass (SKMM). Twenty-two university handball players were randomly assigned to Group 1 (low-movement speed training) or Group 2 (high-movement speed training). Group 1 exercised with a bar speed of 0.75-0.96 m/s, which corresponds to a resistance of approximately 60% 1RM, whereas Group 2 trained at 1.03-1.20 m/s, corresponding to a resistance of approximately 40% 1RM. Both groups exercised three times a week for five weeks, with strength and throwing tests performed at baseline and post-intervention.

    RESULTS: A two-way repeated measures ANOVA was applied, and the results showed the interaction between group and time was not statistically significant for SKMM (p = 0.537), 1RM (p = 0.883), or TV (p = 0.774). However, both groups significantly improved after the five weeks of training: SKMM (3.1% and 3.5%, p 

    Matched MeSH terms: Muscle, Skeletal/physiology
  4. Saeedi P, Black KE, Haszard JJ, Skeaff S, Stoner L, Davidson B, et al.
    Nutrients, 2018 Jul 10;10(7).
    PMID: 29996543 DOI: 10.3390/nu10070887
    Research shows that cardiorespiratory (CRF) and muscular fitness in childhood are associated with a healthier cardiovascular profile in adulthood. Identifying factors associated with measures of fitness in childhood could allow for strategies to optimize cardiovascular health throughout the lifecourse. The aim of this study was to examine the association between dietary patterns and both CRF and muscular fitness in 9⁻11-year-olds. In this study of 398 children, CRF and muscular fitness were assessed using a 20-m shuttle run test and digital hand dynamometer, respectively. Dietary patterns were derived using principal component analysis. Mixed effects linear regression models were used to assess associations between dietary patterns and CRF and muscular fitness. Most children had healthy CRF (99%, FITNESSGRAM) and mean ± SD muscular fitness was 15.2 ± 3.3 kg. Two dietary patterns were identified; “Snacks” and “Fruit and Vegetables”. There were no significant associations between either of the dietary patterns and CRF. Statistically significant but not clinically meaningful associations were seen between dietary patterns and muscular fitness. In an almost exclusively fit cohort, food choice is not meaningfully related to measures of fitness. Further research to investigate diet-fitness relationships in children with lower fitness levels can identify key populations for potential investments in health-promoting behaviors.
    Matched MeSH terms: Muscle, Skeletal/physiology*
  5. Naish KR, Houston-Price C, Bremner AJ, Holmes NP
    Neuropsychologia, 2014 11;64:331-48.
    PMID: 25281883 DOI: 10.1016/j.neuropsychologia.2014.09.034
    Many human behaviours and pathologies have been attributed to the putative mirror neuron system, a neural system that is active during both the observation and execution of actions. While there are now a very large number of papers on the mirror neuron system, variations in the methods and analyses employed by researchers mean that the basic characteristics of the mirror response are not clear. This review focuses on three important aspects of the mirror response, as measured by modulations in corticospinal excitability: (1) muscle specificity; (2) direction; and (3) timing of modulation. We focus mainly on electromyographic (EMG) data gathered following single-pulse transcranial magnetic stimulation (TMS), because this method provides precise information regarding these three aspects of the response. Data from paired-pulse TMS paradigms and peripheral nerve stimulation (PNS) are also considered when we discuss the possible mechanisms underlying the mirror response. In this systematic review of the literature, we examine the findings of 85 TMS and PNS studies of the human mirror response, and consider the limitations and advantages of the different methodological approaches these have adopted in relation to discrepancies between their findings. We conclude by proposing a testable model of how action observation modulates corticospinal excitability in humans. Specifically, we propose that action observation elicits an early, non-specific facilitation of corticospinal excitability (at around 90ms from action onset), followed by a later modulation of activity specific to the muscles involved in the observed action (from around 200ms). Testing this model will greatly advance our understanding of the mirror mechanism and provide a more stable grounding on which to base inferences about its role in human behaviour.
    Matched MeSH terms: Muscle, Skeletal/physiology*
  6. Ajit Singh DK, Bailey M, Lee R
    Muscle Nerve, 2011 Jul;44(1):74-9.
    PMID: 21488056 DOI: 10.1002/mus.21998
    Loss of lumbar extensor muscle strength and fatigue resistance may contribute to functional disability.
    Matched MeSH terms: Muscle, Skeletal/physiology*
  7. Marconi G, Gopalai AA, Chauhan S
    Med Biol Eng Comput, 2023 May;61(5):1167-1182.
    PMID: 36689083 DOI: 10.1007/s11517-023-02778-2
    This simulation study aimed to explore the effects of mass and mass distribution of powered ankle-foot orthoses, on net joint moments and individual muscle forces throughout the lower limb. Using OpenSim inverse kinematics, dynamics, and static optimization tools, the gait cycles of ten subjects were analyzed. The biomechanical models of these subjects were appended with ideal powered ankle-foot orthoses of different masses and actuator positions, as to determine the effect that these design factors had on the subject's kinetics during normal walking. It was found that when the mass of the device was distributed more distally and posteriorly on the leg, both the net joint moments and overall lower limb muscle forces were more negatively impacted. However, individual muscle forces were found to have varying results which were attributed to the flow-on effect of the orthosis, the antagonistic pairing of muscles, and how the activity of individual muscles affect each other. It was found that mass and mass distribution of powered ankle-foot orthoses could be optimized as to more accurately mimic natural kinetics, reducing net joint moments and overall muscle forces of the lower limb, and must consider individual muscles as to reduce potentially detrimental muscle fatigue or muscular disuse. OpenSim modelling method to explore the effect of mass and mass distribution on muscle forces and joint moments, showing potential mass positioning and the effects of these positions, mass, and actuation on the muscle force integral.
    Matched MeSH terms: Muscle, Skeletal/physiology
  8. Amiri-Khorasani M, Abu Osman NA, Yusof A
    J Strength Cond Res, 2011 Jun;25(6):1647-52.
    PMID: 21358428 DOI: 10.1519/JSC.0b013e3181db9f41
    The purpose of this study was to examine the effects of static and dynamic stretching within a pre-exercise warm-up on hip dynamic range of motion (DROM) during instep kicking in professional soccer players. The kicking motions of dominant legs were captured from 18 professional adult male soccer players (height: 180.38 ± 7.34 cm; mass: 69.77 ± 9.73 kg; age: 19.22 ± 1.83 years) using 4 3-dimensional digital video cameras at 50 Hz. Hip DROM at backward, forward, and follow-through phases (instep kick phases) after different warm-up protocols consisting of static, dynamic, and no-stretching on 3 nonconsecutive test days were captured for analysis. During the backswing phase, there was no difference in DROM after the dynamic stretching compared with the static stretching relative to the no-stretching method. There was a significant difference in DROM after the dynamic stretching compared with the static stretching relative to the no-stretching method during (a) the forward phase with p < 0.03, (b) the follow-through phase with p < 0.01, and (c) all phases with p < 0.01. We concluded that professional soccer players can perform a higher DROM of the hip joint during the instep kick after dynamic stretching incorporated in warm-ups, hence increasing the chances of scoring and injury prevention during soccer games.
    Matched MeSH terms: Muscle, Skeletal/physiology
  9. Amiri-Khorasani M, Abu Osman NA, Yusof A
    J Strength Cond Res, 2011 Apr;25(4):1177-81.
    PMID: 20838249 DOI: 10.1519/JSC.0b013e3181d6508c
    This study investigated the number of trials necessary to obtain optimal biomechanical responses in 10 consecutive soccer instep kicks. The kicking motions of dominant legs were captured from 5 experienced and skilled adult male soccer players (height: 184.60 ± 4.49 cm; mass: 80 ± 4.24 kg; and age: 25.60 ± 1.14 years) using a 3D infrared high-speed camera at 200 Hz. Some of the important kinematics and kinetics parameters are maximum thigh angular velocity, maximum lower leg angular velocity, maximum of thigh moment, maximum lower leg moment at forward and impact phases, and finally maximum ball velocity after impact selected to be analyzed. There was a significant decrease of ball velocity between the first and the fifth kick and the subsequent kicks. Similarly, the lower leg angular velocity showed a significant decrease after the fifth kick and thereafter. Compared with the first kick, the thigh angular velocity has been shown to decrease after the sixth kick and thereafter, and the thigh moment result of the sixth kick was significantly lower when compared with the first kick. Moreover, the lower leg moment result of the fourth kick was significantly lower in comparison with the first kick. In conclusion, it seems that 5 consecutive kicks are adequate to achieve high kinematics and kinetics responses and selecting more than 5 kicks does not result in any high biomechanical responses for analysis.
    Matched MeSH terms: Muscle, Skeletal/physiology
  10. Zulfikri N, Selvanayagam VS, Yusof A
    J Sport Rehabil, 2021 Jan 19;30(5):717-724.
    PMID: 33465761 DOI: 10.1123/jsr.2019-0483
    CONTEXT: Badminton continues to be a highly competitive sport where training is introduced at an early age and load has intensified. This exposes players to a greater risk of injuries, in particular when assessing related training outcomes such as strength, agonist-antagonist ratio, and bilateral deficit among adolescents where age- and sex-associated growth and development should be considered.

    OBJECTIVE: To evaluate strength profile of the upper and lower limbs among adolescent elite Malaysian badminton players.

    DESIGN: Cross-sectional study.

    SETTING: Laboratory.

    PARTICIPANTS: Forty-eight asymptomatic athletes (24 males and 24 females) were grouped into early and late adolescence (13-14 y old and 15-17 y old, respectively).

    MAIN OUTCOME MEASURE(S): Strength (absolute and normalized) of the external/internal rotators of the shoulder and flexor/extensor of the knee and strength derivatives, conventional strength ratio (CSR), dynamic control ratio (DCR), and bilateral deficits were measured.

    RESULTS: Males showed greater strength in all strength indices (P < .05). The older group had greater strength compared to younger for most of the upper and lower limb indices (P < .05); these effects diminished when using normalized data. For females, there was no age group effect in the shoulder and knee strength. All players displayed lower shoulder and knee normative values for CSR and DCR. Dominant and non-dominant knee strength were comparable between sex and age groups.

    CONCLUSIONS: For males, growth and maturation had a greater contribution to strength gained compared to training, whereas for females, growth, maturation, and training did not improve strength. The normalized data indicated that training did not improve all indices measured apart from external rotator strength in females. All players also displayed lower normative values of CSR and DCR. These results suggest that training in elite adolescent Malaysian badminton players lacks consideration of strength gain and injury risk factors.

    Matched MeSH terms: Muscle, Skeletal/physiology
  11. Hussain J, Sundaraj K, Subramaniam ID, Lam CK
    J Musculoskelet Neuronal Interact, 2019 09 01;19(3):276-285.
    PMID: 31475934
    OBJECTIVE: The objective of this study was to investigate fatigue in the three heads of the triceps brachii (TB) muscle using surface electromyography (sEMG) obtained at 30%, 45% and 60% of maximal voluntary contraction (MVC).

    METHODS: Twenty-five subjects performed isometric elbow extension until failure, and the rate of fatigue (ROF), time to fatigue (TTF) and normalized TTF (NTTF) were statistically analysed. Subsequently, the behaviour of root-mean-square (RMS), mean-power frequency (MPF) and median-power frequency (MDF) under pre-, onset- and post-fatigue conditions were compared.

    RESULTS: The findings indicated that, among the heads, ROF was statistically significant at 30% and 45% MVC (P<0.05) but TTF and NTTF at all intensities was statistically insignificant (P>0.05). For every head, only TTF was statistically significant (P<0.05) at different intensities. MPF and MDF under pre-, onset- and post-fatigue conditions were statistically significant (P<0.05) among the heads at all intensities, whereas RMS showed no such behaviour.

    CONCLUSION: The investigated parameters reveal that the three heads of TB act independently before fatigue onset and appear to work in union after fatigue. Synergist head pairs exhibit similar spectral and temporal behaviour in contrast to the non-synergist TB head pair. We find spectral parameters to be more specific predictors of fatigue.

    Matched MeSH terms: Muscle, Skeletal/physiology*
  12. Talib I, Sundaraj K, Lam CK
    J Musculoskelet Neuronal Interact, 2020 06 01;20(2):194-205.
    PMID: 32481235
    OBJECTIVE: To analyse the influence of muscle fibre axis on the degree of crosstalk in mechanomyographic (MMG) signals during sustained isometric forearm flexion, pronation and supination exercises performed at 80% maximum voluntary contraction (MVC) at an elbow joint angle of 90°.

    METHODS: MMG signals in longitudinal, lateral and transverse directions of muscle fibres were recorded from the elbow flexors of twenty-five male subjects using triaxial accelerometers. Cross-correlation coefficients were used to quantify the degree of crosstalk in all nine possible pairs of fibre axes, all muscle pairs and all exercises.

    RESULTS: MMG root mean square (RMS) was statistically significant among the fibre axes (p<0.05, η2=0.17- 0.34) except for biceps brachii and brachioradialis in supination and brachialis in flexion. Overall mean crosstalk values in the three muscle pairs (biceps brachii & brachialis, brachialis & brachioradialis and brachioradialis & biceps brachii) were found to be 6.09-52.17%, 4.01-61.42% and 2.16-51.85%, respectively. Crosstalk values showed statistical significance among all nine axes pairs (p<0.05, η2=0.16-0.51) except for biceps brachii & brachialis during pronation. The transverse axes pair generated the lowest mean crosstalk values (2.16-9.14%).

    CONCLUSION: MMG signals recorded using accelerometers from the transverse axes of muscle fibres in the elbow flexors are unique and yield the least amount of crosstalk.

    Matched MeSH terms: Muscle, Skeletal/physiology*
  13. Talib I, Sundaraj K, Lam CK, Sundaraj S
    J Musculoskelet Neuronal Interact, 2018 12 01;18(4):446-462.
    PMID: 30511949
    This systematic review aims to categorically analyses the literature on the assessment of biceps brachii (BB) muscle activity through mechanomyography (MMG). The application of our search criteria to five different databases identified 319 studies. A critical review of the 48 finally selected records, revealed the diversity of protocols and parameters that are employed in MMG-based assessments of BB muscle activity. The observations were categorized into the following: muscle torque, fatigue, strength and physiology. The available information on the muscle contraction protocol, sensor(s), MMG signal parameters and obtained results were then tabulated based on these categories for further analysis. The review affirms that - 1) MMG is suitable for skeletal muscle activity assessment and can be employed potentially for further investigation of the BB muscle activity and condition (e.g., force, torque, fatigue, and contractile properties), 2) a majority of the records focused on static contractions of the BB, and the analysis of dynamic muscle contractions using MMG is thus a research gap, and 3) very few studies have focused on the analysis of BB muscle activity under externally stimulated contractions. Taken together, the findings of this review on BB activity assessment using MMG affirm the potential of MMG as an alternative tool.
    Matched MeSH terms: Muscle, Skeletal/physiology*
  14. Loh PY, Hayashi K, Nasir N, Muraki S
    J Mot Behav, 2020;52(5):634-642.
    PMID: 31571525 DOI: 10.1080/00222895.2019.1670128
    This study investigated the muscle activity and force variability in response to perturbation of assistive force during isometric elbow flexion. Sixteen healthy right-handed young men (age: 22.0 ± 1.1 years; height: 171.9 ± 4.8 cm; weight 68.4 ± 11.2 kg) were recruited and the muscle activity of biceps brachii and triceps brachii were assessed using surface electromyography. Workload force and assistive force applied on isometric elbow flexion significantly affected the changes in both biceps and triceps muscle activities. A higher assistive force was shown to result in reduced biceps muscle activity compared to the unassisted period. In contrast, the efficiency of the assistive force acting on the biceps decreased as the assistive force increased. In general, the force variability of the biceps muscle remained approximately the same at lower workload force conditions than that at higher workload force conditions. In conclusion, higher assistive force may not yield a higher performance efficiency in human-assistive force interaction.
    Matched MeSH terms: Muscle, Skeletal/physiology*
  15. Hameed HK, Wan Hasan WZ, Shafie S, Ahmad SA, Jaafar H, Inche Mat LN
    J Med Eng Technol, 2020 Apr;44(3):139-148.
    PMID: 32396756 DOI: 10.1080/03091902.2020.1753838
    To make robotic hand devices controlled by surface electromyography (sEMG) signals feasible and practical tools for assisting patients with hand impairments, the problems that prevent these devices from being widely used have to be overcome. The most significant problem is the involuntary amplitude variation of the sEMG signals due to the movement of electrodes during forearm motion. Moreover, for patients who have had a stroke or another neurological disease, the muscle activity of the impaired hand is weak and has a low signal-to-noise ratio (SNR). Thus, muscle activity detection methods intended for controlling robotic hand devices should not depend mainly on the amplitude characteristics of the sEMG signal in the detection process, and they need to be more reliable for sEMG signals that have a low SNR. Since amplitude-independent muscle activity detection methods meet these requirements, this paper investigates the performance of such a method on people who have had a stroke in terms of the detection of weak muscle activity and resistance to false alarms caused by the involuntary amplitude variation of sEMG signals; these two parameters are very important for achieving the reliable control of robotic hand devices intended for people with disabilities. A comparison between the performance of an amplitude-independent muscle activity detection algorithm and three amplitude-dependent algorithms was conducted by using sEMG signals recorded from six hemiparesis stroke survivors and from six healthy subjects. The results showed that the amplitude-independent algorithm performed better in terms of detecting weak muscle activity and resisting false alarms.
    Matched MeSH terms: Muscle, Skeletal/physiology*
  16. Hébert-Losier K, Yin NS, Beaven CM, Tee CCL, Richards J
    J Electromyogr Kinesiol, 2019 Feb;44:36-45.
    PMID: 30496944 DOI: 10.1016/j.jelekin.2018.11.009
    Kinesiology-type tape (KTT) has become popular in sports for injury prevention, rehabilitation, and performance enhancement. Many cyclists use patella KTT; however, its benefits remain unclear, especially in uninjured elite cyclists. We used an integrated approach to investigate acute physiological, kinematic, and electromyographic responses to patella KTT in twelve national-level male cyclists. Cyclists completed four, 4-minute submaximal efforts on an ergometer at 100 and 200 W with and without patella KTT. Economy, energy cost, oxygen cost, heart rate, efficiency, 3D kinematics, and lower-body electromyography signals were collected over the last minute of each effort. Comfort levels and perceived change in knee stability and performance with KTT were recorded. The effects of KTT were either unclear, non-significant, or clearly trivial on all collected physiological and kinematic measures. KTT significantly, clearly, and meaningfully enhanced vastus medialis peak, mean, and integrated electromyographic signals, and vastus medialis-to-lateralis activation. Electromyographic measures from biceps femoris and biceps-to-rectus femoris activation ratio decreased in either a significant or clinically meaningful manner. Despite most cyclists perceiving KTT as comfortable, increasing stability, and improving performance, the intervention exerted no considerable effects on all physiological and kinematic measures. KTT did alter neuromuscular recruitment, which has potential implications for injury prevention.
    Matched MeSH terms: Muscle, Skeletal/physiology
  17. Ku PX, Abu Osman NA, Wan Abas WAB
    J Biomech, 2016 Dec 08;49(16):3943-3948.
    PMID: 27865478 DOI: 10.1016/j.jbiomech.2016.11.006
    Balance control plays an important role in maintaining daily activity. However, studies on postural control among middle-aged adults are scarce. This study aims (i) to examine directional control (DCL) and electromyography activity (EMG) for different stability levels, and (ii) to determine left-right asymmetry for DCL and muscle activity among sedentary middle-aged adults. Twenty healthy, middle-aged adults (10 males, 10 females; age=50.0±7.5yrs; body height: 1.61±0.10m; body mass: 70.0±14.5kg) participated in the study. EMG for left and right side of rectus femoris (RF), biceps femoris (BF), and medial gastrocnemius (MG) were recorded. Two-way repeated measures analysis of variance was used to assess the effect of dynamic level on DCL and EMG, whereas independent sample t-test was conducted to analyse the asymmetries of DCL and EMG for the left and right leg. When the dynamic tilt surface increased, DCL scores significantly decreased (except forward, forward-rightward, and backward-leftward direction) and only RF muscle indicated significant differences. Left-right asymmetry was found in BF and MG muscles. No significant gender difference was observed in DCL and EMG. These data demonstrated that increased dynamic tilt surface may increase the displacement of center of pressure of certain directions, and stimulate RF activity in dynamic stance among sedentary middle-aged adults. Further studies should be conducted to examine the dynamic stance and muscle activity of the lower limb in age-matched patient groups with balance abnormalities.
    Matched MeSH terms: Muscle, Skeletal/physiology*
  18. Yap YT, Gouwanda D, Gopalai AA, Chong YZ
    J Biomech Eng, 2023 Feb 01;145(2).
    PMID: 36082472 DOI: 10.1115/1.4055564
    Musculoskeletal modeling and simulation have been an emerging trend in human gait analysis. It allows the user to isolate certain biomechanical conditions and elucidate the dynamics of joints and muscles. This study used an open-source musculoskeletal modeling and simulation tool, opensim to investigate the biomechanical effect of knee brace. It collected gait data from thirty-eight participants and examined the gait spatio-temporal parameters, joint angles, and joint moments. Static optimization was performed to estimate the lower extremity muscle force. Statistical analysis was conducted to identify the difference between normal and braced gaits. The results demonstrated the feasibility of this method to investigate the interaction and coordination of lower extremity joints and muscles. The knee brace constrained the range of the motion of the knee during walking. It also changed the walking speed, step length, and stance-to-swing ratio. Several significant differences were found in the joint moments and muscle forces of the rectus femoris, gastrocnemius, soleus and tibialis anterior. Musculoskeletal modeling and simulation tool offers a less invasive and practical alternative to analyze human motion. It also provides a means to investigate the effect of medical devices such as knee brace, which can be potentially beneficial for the future design and development of such devices and for the derivation of future rehabilitation treatment to improve patient's gait.
    Matched MeSH terms: Muscle, Skeletal/physiology
  19. Shariat A, Lam ETC, Shaw BS, Shaw I, Kargarfard M, Sangelaji B
    J Back Musculoskelet Rehabil, 2017;30(3):641-647.
    PMID: 28372315 DOI: 10.3233/BMR-160526
    STUDY DESIGN: True experimental design.

    BACKGROUND: The back squat is an integral aspect of any resistance training program to improve athletic performance. It is also used for injury prevention of the lower limbs.

    OBJECTIVE: The purpose of this study was to examine the effect of back squat training at different intensities on strength and flexibility of the hamstring muscle group (HMG).

    METHODS: Twenty-two male recreational bodybuilders with at least two years of experience in resistance training were recruited to participate in a nine-week training program. They were randomly assigned to a heavy back squat group (90-95% of one repetition maximum) or a moderate-intensity back squat group (60-65% of one repetition maximum).

    RESULTS: The heavy back squat group resulted in a significantly (p < 0.001) increased in one repetition maximum strength but a significant (p < 0.001) reduction in HMG flexibility when compared to their counterparts. The results of the study indicate that while a heavy back squat training program is effective in improving strength, it has an adverse effect on the flexibility of the HMG.

    CONCLUSION: The implication of this study is that there is a tradeoff between strength and flexibility and trainers should select the appropriate training protocols for their athletes to maximize athletic performance.

    Matched MeSH terms: Muscle, Skeletal/physiology
  20. Lane SC, Camera DM, Lassiter DG, Areta JL, Bird SR, Yeo WK, et al.
    J Appl Physiol (1985), 2015 Sep 15;119(6):643-55.
    PMID: 26112242 DOI: 10.1152/japplphysiol.00857.2014
    We determined the effects of "periodized nutrition" on skeletal muscle and whole body responses to a bout of prolonged exercise the following morning. Seven cyclists completed two trials receiving isoenergetic diets differing in the timing of ingestion: they consumed either 8 g/kg body mass (BM) of carbohydrate (CHO) before undertaking an evening session of high-intensity training (HIT) and slept without eating (FASTED), or consumed 4 g/kg BM of CHO before HIT, then 4 g/kg BM of CHO before sleeping (FED). The next morning subjects completed 2 h of cycling (120SS) while overnight fasted. Muscle biopsies were taken on day 1 (D1) before and 2 h after HIT and on day 2 (D2) pre-, post-, and 4 h after 120SS. Muscle [glycogen] was higher in FED at all times post-HIT (P < 0.001). The cycling bouts increased PGC1α mRNA and PDK4 mRNA (P < 0.01) in both trials, with PDK4 mRNA being elevated to a greater extent in FASTED (P < 0.05). Resting phosphorylation of AMPK(Thr172), p38MAPK(Thr180/Tyr182), and p-ACC(Ser79) (D2) was greater in FASTED (P < 0.05). Fat oxidation during 120SS was higher in FASTED (P = 0.01), coinciding with increases in ACC(Ser79) and CPT1 as well as mRNA expression of CD36 and FABP3 (P < 0.05). Methylation on the gene promoter for COX4I1 and FABP3 increased 4 h after 120SS in both trials, whereas methylation of the PPARδ promoter increased only in FASTED. We provide evidence for shifts in DNA methylation that correspond with inverse changes in transcription for metabolically adaptive genes, although delaying postexercise feeding failed to augment markers of mitochondrial biogenesis.
    Matched MeSH terms: Muscle, Skeletal/physiology
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