MyMedR

Normal range estimates of serum chemistry values in adult west Malaysians

Lim KL, Beng CG, Lau KS, Singh GN

Med J Malaysia, 1974 Mar;28(3):154-9.

Matched MeSH terms: Blood Chemical Analysis*; Blood Glucose/analysis; Blood Proteins/analysis; Creatinine/blood; Enzymes/blood; Uric Acid/blood

Fulltext The relationships between thyroid hormones and thyroid-stimulating hormone with lipid profile in euthyroid men

Chin KY, Ima-Nirwana S, Mohamed IN, Aminuddin A, Johari MH, Ngah WZ

Int J Med Sci, 2014;11(4):349-55.

PMID: 24578612 DOI: 10.7150/ijms.7104

Alteration in lipid profile is a common observation in patients with thyroid dysfunction, but the current knowledge on the relationship between lipids and thyroid hormone levels in euthyroid state is insufficient. The current study aimed to determine the association between thyroid hormones and thyroid-stimulating hormone (TSH) with lipid profile in a euthyroid male population.

Matched MeSH terms: Cholesterol/blood; Lipids/blood*; Cholesterol, HDL/blood; Cholesterol, LDL/blood; Thyroid Hormones/blood*; Thyrotropin/blood*; Thyroxine/blood; Triglycerides/blood; Triiodothyronine/blood

Fulltext Long-term effects of honey on cardiovascular parameters and anthropometric measurements of postmenopausal women

Ab Wahab SZ, Nik Hussain NH, Zakaria R, Abdul Kadir A, Mohamed N, Tohit NM, et al.

Complement Ther Med, 2018 Dec;41:154-160.

PMID: 30477832 DOI: 10.1016/j.ctim.2018.08.015

OBJECTIVE: To investigate the long-term effects of Tualang Honey versus Honey Cocktail (mixture of honey, bee bread, and royal jelly) on cardiovascular markers and anthropometric measurements of postmenopausal women.

METHODS: We conducted a randomised, double blinded, two-armed parallel study comparing 20 g/day of Tualang Honey versus 20 g/day Honey Cocktail among postmenopausal women aged 45-65 years. The cardiovascular parameters and anthropometrics measurements were assessed at baseline, 6 months, and 12 months of the intervention.

RESULTS: 100 subjects were successfully randomised into the groups. There was a significant decrease in the diastolic blood pressure from 77.92 mmHg at baseline to 73.45 mmHg at 12 months (F-statistic = 2.55, p-value = 0.047) in the Tualang Honey group compared to Honey Cocktail. There was also a significant decrease in the fasting blood sugar from 6.11 mmol/L at baseline to 5.71 mmol/L at 12 months (F-statistic = 4.03, p-value = 0.021) in the Tualang Honey group compared to the Honey Cocktail group. The body mass index remained unchanged at 27 kg/m2 (F-statistic = 1.60, p-value = 0.010) throughout 12 months of the intervention in the Honey Cocktail group.

CONCLUSION: Subjects who received Honey Cocktail showed remarkable effects on body mass index. However, Tualang Honey supplementation showed superior effect in lowering diastolic blood pressure and fasting blood sugar compared to Honey Cocktail. Further studies are required to ascertain the underlying mechanism(s) of Tualang Honey and Honey Cocktail on each observed parameter.

Matched MeSH terms: Blood Glucose/physiology*; Blood Pressure/physiology*; Lipoproteins/blood

Fulltext The influence of fibrinogen and other plasma proteins on the ESR and plasma viscosity

Ishak R, Hassan K

Med J Malaysia, 1985 Sep;40(3):191-5.

PMID: 3842714

Matched MeSH terms: Blood Proteins/analysis*; Blood Sedimentation*; Blood Viscosity*

Fulltext Acquired platelet dysfunction with eosinophilia (APDE): an underrecognised condition

Ramanathan M, Duraisamy G

Med J Malaysia, 1987 Mar;42(1):53-5.

PMID: 3431503

We present three cases of Acquired Platelet Dysfunction with Eosinophilia (APDE). The importance of recognising this benign condition, which usually does not require any specific therapy, is stressed to avoid the pitfalls of diagnosing more serious bleeding disorders in children presenting with ecchymosis.

Matched MeSH terms: Blood Platelet Disorders/blood*; Eosinophilia/blood*; Purpura, Thrombocytopenic/blood

Protein variation and systematics in Malayan rats of the subgenus Lenothrix (Rodentia: Muridae, genus Rattus Fischer)

Chan KL, Dhaliwal SS, Yong HS

Comp. Biochem. Physiol., B, 1978;59(4):345-51.

PMID: 318285

1. Electrophoretic variations of 9 erythrocyte proteins, coded by a separate gene locus each, were analysed in and among the 5 Malayan species of Rattus belonging to the subgenus Lenothrix. 2. The average proportion of loci heterozygous per individual for the taxa analysed is 0.037. 3. The results obtained confirm the specific status of the 5 taxa studied. With respect to the relative affinities among the species studied, the present results could resolve the discrepancies between conclusions based on morphological evidence and those based on cytological evidence. 4. The 5 species of Rattus studied may be assigned to 4 groups and comparative data suggest that these groups are relatively distantly related to one another.

Matched MeSH terms: Blood Proteins/genetics; Blood Proteins/isolation & purification*; Muridae/blood*; Rodentia/blood

Duffy phenotypes in Malaysian populations: correction of previous unusual findings

Lewis GE, Miller LH, Ibrahim L, Wong PW, McGinniss M, Ooi WL

Trans R Soc Trop Med Hyg, 1988;82(3):509-10.

PMID: 3068862

Duffy phenotypes were determined for 314 Malaysian Orang Asli. The most common gene, Fya, was present in 313; there were no Duffy negative individuals. A previous study found evidence of Plasmodium vivax infection in 5 of 7 Orang Asli reported to be of the Duffy negative genotype. In this study, 5 of the 7 previously tested Orang Asli were retested in triplicate, and each of the 5 was found to be Duffy positive, having the Fya gene and a phenotype of Fy (a + b-).

Matched MeSH terms: Blood Group Antigens*; Duffy Blood-Group System*; Malaria/blood*

Coagulation of Malays and caucasians: a comparative study of two groups of young soldiers

Loncin H

Med J Malaya, 1965 Sep;20(1):85-7.

PMID: 4221440

Matched MeSH terms: Blood Coagulation Tests*; Blood Platelets*; Blood Pressure*

Interrelation of serum cholesterols, ABO-Rh blood groups and body fat

Banerjee B, Saha N

Med J Malaya, 1969 Sep;24(1):41-4.

PMID: 4243842

Matched MeSH terms: Blood Group Antigens*; Cholesterol/blood*; Rh-Hr Blood-Group System*

Fulltext Current status of ambulatory blood pressure monitoring in Asian countries: A report from the HOPE Asia Network

Shin J, Kario K, Chia YC, Turana Y, Chen CH, Buranakitjaroen P, et al.

J Clin Hypertens (Greenwich), 2020 03;22(3):384-390.

PMID: 31696632 DOI: 10.1111/jch.13724

Ambulatory blood pressure monitoring (ABPM) can measure 24-hour blood pressure (BP), including nocturnal BP and diurnal variations. This feature of ABPM could be of value in Asian populations for preventing cardiovascular events. However, no study has yet investigated regarding the use of ABPM in actual clinical settings in Asian countries/regions. In this study, 11 experts from 11 countries/regions were asked to answer questionnaires regarding the use of ABPM. We found that its use was very limited in primary care settings and almost exclusively available in referral settings. The indications of ABPM in actual clinical settings were largely similar to those of home BP monitoring (HBPM), that is, diagnosis of white-coat or masked hypertension and more accurate BP measurement for borderline clinic BP. Other interesting indications, such as nighttime BP patterns, including non-dipper BP, morning BP surge, and BP variability, were hardly adopted in daily clinical practice. The use of ABPM as treatment guidance for detecting treated but uncontrolled hypertension in the Asian countries/regions didn't seem to be common. The barrier to the use of ABPM was primarily its availability; in referral centers, patient reluctance owing to discomfort or sleep disturbance was the most frequent barrier. ABPM use was significantly more economical when it was reimbursed by public insurance. To facilitate ABPM use, more simplified indications and protocols to minimize discomfort should be sought. For the time being, HBPM could be a reasonable alternative.

Matched MeSH terms: Blood Pressure; Blood Pressure Determination; Blood Pressure Monitoring, Ambulatory

Fulltext Diversity of and initiatives for hypertension management in Asia-Why we need the HOPE Asia Network

Kario K, Chia YC, Sukonthasarn A, Turana Y, Shin J, Chen CH, et al.

J Clin Hypertens (Greenwich), 2020 Mar;22(3):331-343.

PMID: 31773883 DOI: 10.1111/jch.13733

The Hypertension Cardiovascular Outcome Prevention and Evidence in Asia (HOPE Asia) Network was set up to improve the management of hypertension in Asia with the ultimate goal of achieving "zero" cardiovascular events. Asia is a diverse continent, and the prevalence of hypertension has increased over the last 30 years. There are a number of Asia-specific features of hypertension and hypertension-related cardiovascular complications, which means that a region-specific approach is needed. White-coat hypertension will become more of an issue over time as Asian populations age, and masked hypertension is more prevalent in Asian than in Western countries. Identifying and treating masked hypertension is important to reduce cardiovascular risk. Abnormal patterns of blood pressure (BP) variability common in Asia include exaggerated early morning BP surge and nocturnal hypertension. These are also important cardiovascular risk factors that need to be managed. Home blood pressure monitoring (HBPM) is an important tool for detecting white-coat and masked hypertension, and monitoring BP variability, and practices in Asia are variable. Use of HBPM is important given the Asia-specific features of hypertension, and strategies are needed to improve and standardize HBPM usage. Development of HBPM devices capable of measuring nocturnal BP along with other information and communication technology-based strategies are key developments in the widespread implementation of anticipation medicine strategies to detect and prevent cardiovascular events in patients with hypertension. Region-wide differences in hypertension prevalence, control, and management practices in Asia highlight the importance of information sharing to facilitate best practices.

Matched MeSH terms: Blood Pressure; Blood Pressure Determination; Blood Pressure Monitoring, Ambulatory

Fulltext Blood lead levels of pregnant women from the Klang Valley

Hisham HJ, Chuah SY, Syarif HL, Nik Nasri I, Fairulnizam MN

Med J Malaysia, 1998 Mar;53(1):76-81.

PMID: 10968142

A study was conducted to compare the blood lead levels of 97 pregnant women warded at the Kuala Lumpur Hospital, according to their ethnicity, residence and place of work. The lead content of venous blood samples was determined with a graphic furnace atomic absorption spectrometer. Blood lead levels of Klang Valley women seem to have decreased from 17.3 micrograms/dl in 1982 to 7.71 micrograms/dl in the present study most probably attributed to the phasing out of leaded gasoline. This level is below the 10 micrograms/dl recommended by the United States Environmental Protection Agency for the public, even though 27.8% of them still have blood lead levels that are equal to or in excess of 10 micrograms/dl. The study shows that certain segments of the population such as Indians (geometric mean = 9.35 micrograms/dl) and housewives (geometric mean = 9.55 micrograms/dl) may still experience blood lead levels that are slightly elevated than the rest of the population.

Matched MeSH terms: Lead/blood*; Pregnancy/blood*

The blood transfusion services in Malaysia

Lopez CG

Malays J Pathol, 1983 Aug;6:1-7.

PMID: 6599863

Matched MeSH terms: Blood Banks/organization & administration*; Blood Banks/trends

Blood examinations to aid oral diagnosis

Omar-Ahmad UD, Lopez CG, Ramanathan K, Keat TC

Dent J Malaysia Singapore, 1968 Feb;8(1):43-53.

PMID: 5248557

Matched MeSH terms: Blood Cell Count; Blood Chemical Analysis; Blood Coagulation Tests

Fulltext Standardized home blood pressure monitoring: Rationale behind the 722 protocol

Lin HJ, Pan HY, Chen CH, Cheng HM, Chia YC, Sogunuru GP, et al.

J Clin Hypertens (Greenwich), 2022 Sep;24(9):1161-1173.

PMID: 36196472 DOI: 10.1111/jch.14549

Home blood pressure (HBP) has been recognized as a prognostic predictor for cardiovascular events, and integrated into the diagnosis and management of hypertension. With increasing accessibility of oscillometric blood pressure devices, HBP monitoring is easy to perform, more likely to obtain reliable estimation of blood pressures, and feasible to document long-term blood pressure variations, compared to office and ambulatory blood pressures. To obtain reliable HBP estimates, a standardized HBP monitoring protocol is essential. A consensus regarding the optimal duration and frequency of HBP monitoring is yet to be established. Based on the current evidence, the "722" protocol, which stands for two measurements on one occasion, two occasions a day (morning and evening), and over a consecutive of 7 days, is most commonly used in clinical studies and recommended in relevant guidelines and consensus documents. HBP monitoring based on the "722" protocol fulfills the minimal requirement of blood pressure measurements to achieve agreement of blood pressure classifications defined by office blood pressures and to predict cardiovascular risks. In the Taiwan HBP consensus, the frequency of repeating the "722" protocol of HBP monitoring according to different scenarios of hypertension management, from every 2 weeks to 3 months, is recommended. It is reasonable to conclude that the "722" protocol for HBP monitoring is clinically justified and can serve as a basis for standardized HBP monitoring.

Matched MeSH terms: Blood Pressure; Blood Pressure Determination/methods

Fulltext Hematological and serum biochemical parameters of rescued Sunda pangolins (Manis javanica) in Singapore

Ahmad AA, Samsuddin S, Oh SJWY, Martinez-Perez P, Rasedee A

J Vet Med Sci, 2018 Dec 11;80(12):1867-1874.

PMID: 30333379 DOI: 10.1292/jvms.17-0585

The Sunda pangolin (Manis javanica) population in Southeast Asia faces threats such as poaching and deforestation. Health assessments of rescued individuals including physical examination and blood work are crucial for clinicians to determine the health status of these animals. The establishments of reference intervals of hematology and serum biochemistry are important for identifying clinical abnormalities. The objectives of our study were to establish blood reference intervals for Sunda pangolins, to determine if there are age and sex related differences in hematology and serum biochemistry, and to compare our results with those of a previous study on confiscated Sunda pangolins in Thailand. Fifty-eight Sunda pangolins were rescued between January 2011 and December 2015. The hematology and serum biochemistry results of 51 clinically normal Sunda pangolins were selected for the establishment of the blood reference intervals. No sex related differences were noted in this study. Age-related differences were observed, in which adult Sunda pangolins had a significantly higher mean corpuscular volume than juveniles, and juvenile Sunda pangolins had significantly higher red blood cell counts and hemoglobin levels than those of the adults (P<0.05). Age-related differences were also noted in several serum biochemistry parameters: alkaline phosphatase (ALP) was significantly higher in juveniles, and total protein was significantly higher in adult Sunda pangolins. Compared to a previous study the white blood cell counts, neutrophil counts, and ALP were higher, and the lymphocyte counts were lower in the present study.

Matched MeSH terms: Aging/blood; Animals, Wild/blood; Xenarthra/blood*

Partition of potassium and calcium stored in blood

Lee TS

Journal of the Malaya Branch of the British Medical Association, 1940;4:295-303.

The rates of rise of the plasma potassium concentrations are not affected by the nature ot the preservative solutions although the solutions influence in a marked degree the rates of haemolysis. The rise in the plasma potassium luvel exhibits two phases. It rises very rapidly for the first ten days of storage, increasing to 12 times the initial concentration in that brief period, after which the change is by comparison much slower. Variation in storage temperature has a greater effect relatively on the increase in the extra-cellular potassium concentration than daily shaking. The plasma calcium level falls by about 25 per cent of the original quantity and then begins to rise when the blood starts to haemolyse. It is suggested that it is the ionised calcium that is affected in this phenomenon. Storage at 38 degree Celcius hastens this fall and rise and so also does the effect of daily shaking.

Matched MeSH terms: Blood

Stored blood. A summary of the behaviour of normal blood stored outside the body, the sources of supply, and the methods for its preservation

Macgregor RGS

Journal of the Malaya Branch of British Medical Association, 1939;3:119-27.

Matched MeSH terms: Blood

Serum protein in beri-beri

Rosedale JL

Malayan Medical Journal, 1929;4:152.

Matched MeSH terms: Blood Proteins

Hyperferritinaemia: An Iron Sword of Autoimmunity

Giemza-Stokłosa J, Islam MA, Kotyla PJ

Curr Pharm Des, 2019;25(27):2909-2918.

PMID: 31686632 DOI: 10.2174/1381612825666190709202804

BACKGROUND: Ferritin is a molecule that plays many roles being the storage for iron, signalling molecule, and modulator of the immune response.

METHODS: Different electronic databases were searched in a non-systematic way to find out the literature of interest.

RESULTS: The level of ferritin rises in many inflammatory conditions including autoimmune disorders. However, in four inflammatory diseases (i.e., adult-onset Still's diseases, macrophage activation syndrome, catastrophic antiphospholipid syndrome, and sepsis), high levels of ferritin are observed suggesting it as a remarkable biomarker and pathological involvement in these diseases. Acting as an acute phase reactant, ferritin is also involved in the cytokine-associated modulator of the immune response as well as a regulator of cytokine synthesis and release which are responsible for the inflammatory storm.

CONCLUSION: This review article presents updated information on the role of ferritin in inflammatory and autoimmune diseases with an emphasis on hyperferritinaemic syndrome.

Matched MeSH terms: Ferritins/blood*; Iron/blood*; Biomarkers/blood; Still's Disease, Adult-Onset/blood; Antiphospholipid Syndrome/blood; Sepsis/blood; Iron Metabolism Disorders/blood*; Macrophage Activation Syndrome/blood

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