The relationship between anaemia and cognitive function was evaluated among 35 Chinese elderly (24 men and 11 women) aged 60 to 85 years (mean age 70.1 ± 6.7 years) from five old folks homes in Klang Valley. They were interviewed to obtain information on social and health status, habitual dietary intake and cognitive function. Hodkinson's Abbreviated Mental Test was used to measure the cognitive function. Haematological indices which included Full Blood Count (FBC), serum iron, serum ferritin, Total Iron Binding Capacity (TIBC), serum folate and serum cobalamine (vitamin B12) were measured using an automated analyzer. Anthropometric measurements and clinical signs of anaemia were also examined. The findings indicated that the prevalence of anaemia as assessed using haemoglobin alone was 22.9%, while iron deficiency anaemia based on low serum iron, microcytic and hypochromic criterion was detected among 5.7% of the sample. Subclinical folate and vitamin B12 deficiencies were diagnosed among 34.3% and 8.6% of the subjects. However, there was no occurrence of megaloblastic anaemia. There was a positive correlation between cognitive score with mid upper arm circumference (MUAC) (r=0.547, p
Polyphenol is a non-nutrient phytochemical compound existed abundantly in plant-based diet which has the properties to prevent age related oxidative damage induced diseases. However, there are difficulties in quantifying its intake and local food frequency questionnaire (FFQ) for the assessment is not available. Therefore, this study aimed to develop and validate FFQ for estimation of dietary polyphenol intake among 93 individuals aged 60 years and above recruited from several senior citizen clubs in Klang Valley. Phase I of the study involved the development of FFQ consisted of 117 items under 9 categories and formation of the database extracted from PHENOL-EXPLORER. In Phase II, the intake of polyphenol estimated using FFQ was compared with reference method consisted of 2-day diet records and diet history questionnaire (DHQ). The mean dietary polyphenol intake estimated from FFQ and the reference method was 2770.7 ± 1552.4 mg/d and 2171.4 ± 898.8 mg/d, respectively. Spearman’s rho and Kendall’s tau-b analysis indicated that there was a significant positive correlation between polyphenol intake estimated from FFQ and reference method (r = 0.41, p < 0.001; r = 0.28, p < 0.001). For Bland-Altman plot, 95.7% of scattered plot fell within ± 1.96 SD limits of agreement revealed that there was good agreement between the two methods used. Cross-classifi cation analysis showed that 36.6% was categorized in the same quartile, 78.5% in identical and contiguous quartiles, with only 3.2% in the opposite quartiles. Regression analysis showed that all categories in FFQ signifi cantly account for the inter-variance for dietary polyphenol intake after controlling for the other variables (R2 = 1.000, p < 0.001). In conclusion, the newly developed FFQ is considered valid and has the potential to be used as a tool to estimate polyphenol intake among elderly individuals in Malaysia.
Relatively less comprehensive web based programme has been developed for detecting risk of mild cognitive impairment (MCI) and further impart preventive strategies and lifestyle education. Thus, this study has developed a comprehensive web based programme for early screening of risk of MCI together with education package for preventing MCI known as WESIHAT 2.0. WESIHAT 2.0 is a senior friendly website which has appropriate design interface facilitating access of older people especially with the use of touch-screen technology. WESIHAT 2.0 has incorporated four major components namely TUA WELLNESS screening tool, which is a comprehensive, online based, 10-item screening tool for detecting risk of MCI, 10-guides for preventing MCI, health diary and healthy food. Evaluation of acceptance of WESIHAT 2.0 was done among 71 people which comprised of 30 older people and 30 caregivers, chosen equally based on ethnic composition and 11 health care professionals who has experience working in the field of geriatric and 2 freelance website developer. All older people and caregivers stated that the content of website was very useful for preventing MCI, however, about 36.4% of health professionals stated several improvements needed to be done before releasing the end-product to the users. Comments given were smaller font size (27.3), addition of more pictures (27.3%), using simpler terms (36.4%) and changing certain design for better view of older people (18.2%). Amendments were made based on each comment given and the finalized website were used for a 6-month intervention programme for neuroprotection among older people who failed to achieve successful aging. It is timely for an online based approach for prevention of MCI. WESIHAT 2.0 is the first website in Malaysia which has been accepted by all older people and caregiver and more than half of healthcare professionals to prevent memory decline.
Excess added sugar consumption is related to poor health outcomes in older adults. The sugar content of local food is limited. However, this information is imperative for understanding potential risks from overconsumption of sugars among older adults. This study was carried out to determine the type and total sugar contents in 70 types of local desserts, snacks and cooked foods, using high performance liquid chromatography. The type of food chosen was based on the highly consumed food by the older adults in Malaysia. The samples were collected in triplicates from local restaurants or stalls located in Selangor, Perak and Johor, stored at -20°C and freeze dried prior to analysis. Results showed that average sugar in each 100 g of local desserts, snacks and cooked foods were 13.69 ± 5.94 g, 8.41 ± 6.15 g and 2.1 ± 1.87 g respectively. The highest sugar content per 100 g samples was found to be in sweet potato donut (kuih keria), mashed banana fritter (cekodok pisang) and noodles with sweet potato gravy (mee rebus). The lowest sugar content per 100 g samples was found to be baked glutinous rice (pulut panggang), vadai and noodle soup (mee sup). Meanwhile, the highest sugar content per standard portion was found to be noodles with sweet potato gravy (mee rebus), peanut pancake (kuih apam balik) and banana savoury (pengat pisang). Percentage of recovery for the sugar analysis was 95.2 ± 6.8%. The main type of sugar found in this analysed food samples was sucrose followed by maltose, glucose, fructose and lactose. Sucrose was the most common added sugars in local desserts, snacks and cooked foods of this study. However, compliance with low added sugar recommendations may not be achievable for the general public. Thus, these findings can be utilised in raising public awareness and assist in better estimation of sugar contents and intake.
The term metabolic syndrome (MetS) describes a clustering of risk factors for cardiovascular disease and type 2 diabetes mellitus which include high blood pressure, low fasting high-density lipoprotein cholesterol (HDL-c), high fasting triglyceride (TG), high fasting blood glucose (BG), and abdominal obesity. The aim of this cross sectional study was to determine the dietary patterns (DPs) associated with MetS among 451 older adults in Malaysia. Food intake was determined using validated Diet History. DP was identified based on 40 food groups by using principal component analysis (PCA), and the factors were rotated by varimax rotation. Fasting venous blood samples were taken to determine HDL-c, TaG and BG level. Blood pressure and anthropometric measurements were also performed. Three major dietary patterns have been identified; 1) bread, spreads and oats, 2) Malaysia traditional pancakes and 3) vegetables and healthy cooked dishes. Three models were built to compare the potential confounder such as age, education years, marital status, calorie intakes, ciggarate smoking and body mass indeks (BMI). Only vegetables and healthy cooked dishes DP was associated with MetS. This DP reflects high consumption of various types of vegetables, noodle in soup, healthy cooked fish or seafood and low consumption of all type of high calorie rice, noodles and fried desserts. For all models, subject in the highest tertile of vegetables and healthy cooked dishes DP had a lower odd ratio (OR) for MetS as compared to lowest tertile. As more potential confounders added in new models, the significant values are increased. After adjustment of body mass index, the association for vegetables and healthy cooked dishes DP was attenuated (OR: 0.67, CI: 0.39-1.16, p: 0.156). In conclusion, high consumption of vegetable and healthy cooked dishes may lower the occurance of MetS among Malaysian elderly.
There is some evidence stated that mood states might influence cognitive functioning, such as episodic memory, working memory and creative problem solving. This study was conducted to evaluate the relationship between mood states and cognitive functioning among older adults with Mild Cognitive Impairment (MCI). This study involved 12 male and 37 female subjects from Klang Valley aged 60 year old and above. MCI was defined based on criteria proposed by Peterson. Cognitive functions of the subjects were accessed using Mini Mental State Examination (MMSE), Rey Auditory Verbal Learning Test (RAVLT), Digit Span, Digit Symbol Substituition Test (DSST) and Visual Reproduction; while mood states including tension, depression, anger, vigour, esteem related affect, fatigue and confusion were accessed using Profile of Mood States (POMS) questionnaire. Total positive subscales score, total negative subscales score and total mood disturbance (TMD) were also calculated. There were significant positive correlations between tension (r = 0.325, p = 0.30), vigour (r = 0.235, p = 0.036), esteem related affect (r = 0.316, p = 0.034) and total positive subscales score (r = 0.307, p = 0.040) with verbal episodic memory as measured using RAVLT fifth trial. In addition, positive correlations were also observed between vigour (r = 0.228, p = 0.035) and total positive subscales score (r = 0.237, p = 0.025) with DSST. After adjusted for confounding factors, subjects who scored higher in esteem related affect (Adjusted OR = 0.390, 95% CI [0.069-0.711], p = 0.019) and tension (Adjusted OR = 0.253, 95% CI [0.075-0.431], p = 0.007) had better verbal episodic memory. Subjects who have higher total positive subscales score were also had faster processing speed (OR = 0.856, 95% CI [0.099-1.614], p = 0.028). However after adjusted for confounding factors, the relationship was not significant (Adjusted OR = 0.383, 95% CI [-0.247-1.013], p = 2.226). Older adults with MCI who had a more positive mood tend to have a better short-term verbal memory and faster processing speed.
Physical performance in older adults is known to decline with ageing. However, there is limited information about physical performance difference among older adults with; successful (SA), usual ageing (UA) and mild cognitive impairment (MCI). The purpose of this study was to compare the differences in physical performance among older adults in these three categorised groups. This study is part of a larger scale population based longitudinal study on neuroprotective model for healthy longevity among older adults (LRGS TUA). Physical performance was assessed using hand grip (HGT; upper limb strength), 2 minutes step (2MST; endurance), sit to stand (STS; lower limb strength), sit and reach (SRT; lower body flexibility), timed up and go (TUG; mobility and balance), back scratch (BST; upper body flexibility) and gait speed (GS; walking speed) tests. Cognitive status was measured using Mini Mental Status Examination (MMSE) for global function, Digit Span for attention and working memory; Rey Auditory Verbal Learning Test (RAVLT) for verbal memory. Participants were categorised in three groups; SA, UA and MCI. SA group were those without diabetes, hypertension, chronic lung disease, cancer, heart diseases and stroke, had normal scores in MMSE (score of >22), optimum self-rated health and no functional limitations measured using Instrumental Activities of Daily Living questionnaire (IADL). Participants with MCI had subjective information of cognitive impairment from caretakers, minimum or low functional limitation, global function with ≤ 19 score on MMSE and 1 SD from below the normal mean of the group for Digit Span and RAVLT. Older adults with UA had minimal or no functional limitation and average scores of MMSE, Digit Span and RAVLT which were between the scores of SA and MCI group. Data was collected among 1291 participants in Phase three of LRGS TUA study. Data was analysed for differences among the three groups using one way ANOVA test. The results showed that majority of older adults was categorized as UA group (71.14%), followed by SA (15.19% ) and MCI (12.72%). Higher performance in physical performance measures except in SRT were demonstrated in SA group compared to MCI and UA groups. Post hoc Sheffe test showed that there was a significant difference (p < 0.05) in the SA and UA group for all tests except for HGT and SRT. MCI and UA groups were significantly different (p < 0.05) in STS, TUG and GST tests. The results suggested that UA and MCI groups had reduced physical performance in lower limb muscle strength, mobility, balance and walking speed compared SA group. Promoting optimum physical performance is important among older adults for successful ageing.
Satu kajian awal bagi menyaring kecelaruan psikogeriatrik di kalangan warga tua telah dijalankan. Tujuan kajian ini dijalankan adalah untuk menentukan peratusan kes kecelaan kognitif, strok dan kemurungan dalam sampel populasi yang berumur di antara 60-89 tahun. Seramai 40 orang subjek dan pemberi maklumat subjek di sekitar Lembah Kelang, Kuala Lumpur dan Selangor dipilih. Alat penyaringan yang digunakan dalam kajian ini ialah Psychogeriatric Assessment Scale (PAS). Psychogeriatric Assessment Scale (PAS) terdiri daripada dua bahagian iaitu laporan subjek dan laporan pemberi maklumat subjek. Laporan subjek digunakan untuk menyaring kecelaan kognitif, strok dan kemurungan. Manakala laporan pemberi maklumat subjek digunakan untuk menyaring kemerosotan kognitif, strok dan perubahan tingkah laku subjek. Dapatan kajian menunjukkan peratusan kes kecelaan kognitif (lelaki 67% kes, perempuan 64.3% kes) dan strok (lelaki 75% kes, perempuan 64.3% kes) yang tinggi di kalangan subjek lelaki dan wanita. Terdapat juga hubungan yang signifikan di antara laporan subjek dengan laporan pemberi maklumat subjek mengikut setiap skala PAS. Alat ujian psikologi PAS mampu menyaring masalah psikogeriatrik di kalangan warga tua dan ketepatan penyaringan dapat dinilai dengan data pemberi maklumat daripada alat ujian PAS. Penyaringan psikogeriatrik adalah penting untuk mengenal pasti kehadiran kecelaan fungsi kognitif dan kemurungan di kalangan warga tua pada peringkat awal.
This study was conducted to determine types of educational needs among stroke patients admitted to Hospital Universiti Sains Malaysia. Stroke patients (n = 41) were conveniently recruited from Medical and Surgical Ward between September to December 2012. Data were obtained using semi-guided administered questionnaires and from the medical reports. Patients were given adequate time to complete the lifestyle history and educational needs on stroke with researcher’s assistance. Instrument on the educational needs consisted of five themes including general information on stroke, management of risk factors, treatments of stroke, rehabilitation and post-stroke problems and post-stroke diet management. Findings indicated majority of the stroke patients were female (58.5%), between 56 to 65 years old (39.0%) and diagnosed with ischemic stroke (68.3%). Patients had history of hypertension (85.4%), diabetes (46.3%), hyperlipidemia (29.3%), ischemic heart disease (22.0%) and atrial fibrillation (2.4%). Eleven of them (26.9%) were ex-smokers and many practice unhealthy lifestyle such as lack of exercise (80.5%) and prefer fried foods (68.3%). Most patients were on multiple pharmacotherapies (92.7%) to treat their medical conditions. Educational needs rated highest need to know among stroke patients were on prevention (92.7%), fi rst aid management (85.4%), complications (85.4%) and recurrence (85.4%) of stroke in general. Other concerned were about possibility of cure with drug (92.7%), range of motion exercise (82.9%), fi sh intake (78.0%), fruit and vegetable consumption (78.0%) after stroke. Findings from this study provide a baseline information on types of educational needs among stroke patients. More patient educational intervention on primary and secondary stroke prevention should be structured in hospital and community settings in the future.
Keywords: Types of educational needs; stroke; patient education; Hospital USM (HUSM)
This study was conducted to determine the score of self-reported visual function index (VF-14) and its correlation with
best corrected visual acuity (BCVA) in the elderly population. Participants were elderly aged 60 years and above recruited
from the on-going population-based longitudinal study on neuroprotective model for healthy longevity (TUA). Visual
acuity was measured using logMAR chart. A self-reported visual function assessment was measured using modified
Bahasa Malaysia Visual Functioning Index (VF-14). A total of 482 (93.05%) from 518 subjects participated in this study.
Mean age was 69.18 ± 5.67 years old and mean best corrected VA was 0.21 ± 0.17 logMAR. Mean VF-14 score was 89.65
± 13.19. Female had lower mean score of self-reported visual function scores compared to male (meanfemale89.21 ± 12.76,
meanmale90.11 ± 13.65) but it was not statistically significant (z = -1.09,p = 0.277). There was a moderate but significant
correlation between VF-14 score and best corrected VA (r = -0.412, p < 0.01). In conclusion, the best corrected visual
acuity alone was not able to become as an indicator to describe changes in VF14 score. This study showed that it only
contributes 17.2% to changes in VF14 score. The combination of many other factors such as socio-demographic factors
(race, educational status, and health problems), contrast sensitivity and stereopsis should be taken into account when
assessing visual function as measured by VF14.
A food premise’s sanitation level can be reflected by the cleanliness of its food contact surfaces. Contaminated food
contact surfaces along with poor handling methods by food handlers may increase the risk of foodborne diseases
through cross-contamination events. This study aimed to assess the microbiological contamination levels on food contact
surfaces of 12 residential college cafeterias in a local university and its correlation with the cafeteria’s premise grade.
The presence of selected indicator and pathogenic microorganisms (total viable count (TVC), total coliform, Escherichia
coli, Staphylococcus aureus, Salmonella spp., and Shigella spp.) on food contact surfaces were also determined. Cutting
boards, knives and utensils (cutleries, bowls and plates) that were used for ready-to-eat food were sampled for this study.
The cafeteria’s premise grade was obtained based on the food premise inspection report by the university Health Centre.
Three cafeterias have significantly higher (p < 0.05) bacterial counts (TVC) as compared to the international standard (1
log CFU/cm2
). E. coli was only found in 2 cafeterias while Salmonella spp. was only detected on 7 of the cafeterias. Cutting
boards were identified as the most contaminated food contact surface whereas utensils were the least contaminated. There
was only a weak correlation between the microbiological levels on food contact surfaces and the cafeteria’s inspection
grade (r = 0.02 p > 0.01). This study demonstrated that the sanitation level of food contact surfaces in the residential
college cafeterias was only average. Improvements need to be done to increase the sanitation level of the cafeterias, thus
assuring the safety of the food for consumers.
Microbiological contaminations in the laboratories create not only diagnostic issues but also pose a major health risk to lab users. This study was conducted to determine the airborne microbial contamination in seven selected laboratories (KA, KP, PB, NA, BP, CR and MB) at a local public university in Malaysia and to assess the level of contamination on the contact surfaces of the studied laboratories. Two types of sampling methods were used in this study; passive air sampling and contact surface swab sampling. The total microbial counts were determined using Tryptone Soya agar (bacterial count) and Potato Dextrose agar (fungal count). Results showed that NA laboratory had the highest level of total microbial contamination (20.33 ± 3.35 CFU/cm3). Most laboratories had significantly higher (p < 0.05) air fungal contamination level compared to bacterial contaminations except for PB and NA laboratories. Significant differences were observed for airborne bacterial contamination readings between sampling time (during working hours vs after hours) for all laboratories except for BP and CR. Overall, bacterial contamination was the highest for incubator door handles’ samples from MB laboratory with an average reading of 93.00 ± 1.43 CFU/cm2 whereas the highest fungal contamination level was obtained from door knobs and work benches, both from CR laboratory with an average reading of 73.33 ± 6.67 CFU/cm2 and 73.33 ± 0.58 CFU/cm2 respectively. Findings from this study could assist in monitoring the efficacy of the existing laboratory management systems namely on the good laboratory practices including aseptic techniques, care for laboratory hygiene and cross-contamination control practices by the laboratory users to ensure that the microbiological contaminations in the laboratories are minimized.
The World Health Organisation recommends healthcare practitioners to equip themselves with appropriate skills to assess the psychological distress in women attending the antenatal and postnatal healthcare. Nevertheless, little is known about the healthcare practitioners’ perceptions of postnatal depression and its management. The aims of this review were: (1) to explore the experiences of healthcare practitioners in caring for women with postnatal depression in different countries and (2) to identify any qualitative study conducted in Malaysia regarding the healthcare practitioners’ perceptions of postnatal depression. To achieve these objectives, a qualitative synthesis of studies reporting the healthcare practitioners’ experience of managing women with postnatal depression was conducted. A search in CINAHL, PubMed, MEDLINE, PsycINFO and ASSIA databases was performed using specific keywords and published peer-reviewed articles from 2006 to 2016 were screened for inclusion criteria. A total of 15 relevant studies were identified and reviewed. The studies included were conducted in eight different countries: America, Australia, United Kingdom, Brazil, Canada, Greek, Mexico and Slovenia. No study conducted in Malaysia was found. This review suggestedthat the experiences of managing women with postnatal depression were relatively similar among the healthcare professionals in different countries. The main limitations reported by the healthcare practitioners were the lack of resources on maternal mental health and the absence of policy regarding the management of postnatal depression. Further research should investigate how Malaysian healthcare practitioners perceive postnatal depression and their roles in its management to provide more insights into the current clinical practice in Malaysia for postnatal depression.
Malaysia was ranked at 148 by World Health Organization (WHO) in suicide statistic for 2012, where males had a higher
tendency to commit suicide, recording a 4.7 per 100,000 in comparison to female (1.5 per 100,000). As hanging is one of
the most common methods to commit suicide, this retrospective study was conducted to observe the incidence of suicide
by hanging in Klang Valley from four different hospitals. The current study is conducted to provide local database of
suicide occurrence by hanging in Klang Valley. A total of 893 suicide cases by hanging from 2007 to 2016 were recorded
from post mortem records and analysed. Suicide rates in Klang Valley showed a rising trend from 2007 to 2016. Males
from age group 30 to 34 years old and females from 20 to 24 years old have the highest number of suicide fatalities
compared to other age groups. Meanwhile, fatalities from the age group of 10 to 14 years old and 80 years old and above
showed similar result which is only 7%. 78% of the fatalities were recognized as Malaysian and half of them were Indian.
Majority of the victims/cases (45%) who committed suicide by hanging are of Hindu religious denomination. Non-citizen
in Malaysia that have the highest suicide rates were from Nepal, Indonesia and Myanmar. Victims also committed suicide
more during the day and the peak hours being at 12.00 pm to 5.59 pm.
Traditionally, Clinacanthus nutans (CN) or locally named as ‘Belalai Gajah’ is one of the herbal plant claimed to be
able to treat cancer. The aimd of this study are to extract, isolate and characterize the active anticancer compound
from CN and to determine the mode of cell death induced by the compound. Bioassay guided fractionation was done on
the CN extract by using column chromatography. The cytotoxicity activities of these fractions toward HeLA cells were
examined by MTT assay. The nuclear morphology was examined by Hoechst 33258 staining and the cell cycle arrest
was evaluated by propium iodide staining using flow cytometry. The presence of active compound in the chosen fraction
was determined by Liquid Chromatography Mass Spectrometry (LCMS). Out of 16 fractions collected, Fraction 11(F11)
showed the lowest IC50 value with 27 ± 2.6 µg/mL. The value of IC50 for F11 towards normal cell, NIH 3T3 cell and L929
cell, were 70 ± 4.0 µg/mL and 45 ± 1.5 µg/mL respectively. These values were higher than tamoxifen, therefore indicating
that tamoxifen is more toxic towards normal cells compared to F11. Nuclear morphology of HeLA cell displayed DNA
fragmentation, nuclear condensation and formation of apoptotic bodies upon treatment with F11 for 24 hours. The cell
cycle distribution of HeLA cell treated with F11 was arrested at G1 phase. The active compound identified to potentially
possess the anticancer property is 19-Oxo-all-trans-retinoic acid. In conclusion, 19-Oxo-all-trans-retinoic acids from
F11 of the CN extract, is a potential anticancer agent for cervical cancer.
Parents or caregivers of children with learning disabilities have been shown to experience increases in stress and greater negative caregiving consequences than those with typically developing children. The current study sought to assess the perceived stress among Malay caregivers of children with learning disabilities in Kelantan. The Malay version of Perceived Stress Scale 10 items was administered to a sample of 40 caregivers of children with learning disabilities who were registered to five Pusat Pemulihan Dalam Komuniti (PDK) in Kelantan. Higher scores indicate higher levels of stress. The caregivers had mean age of 47.68 (SD = 9.18) years old, of whom 90% were fathers or mothers. Ninety percent of them were married, majority were unemployed or housewives and had secondary school education. The majority of children with learning disabilities were males and half of them were Down Syndrome children. The mean total Perceived Stress Scale score of the caregivers was 16.77 (SD = 5.74). There were no significant associations between total perceived stress score and any of the independent variables. The mean total perceived stress score showed that the perceived stress level was in the category of slightly higher than average and health concern level was high, while the average stress level was between score of 12 to 15. In conclusion, this result indicated that the caregivers had slightly higher levels of stress than the average score, and might increase susceptibility to stress-induced illness.
Hibiscus sabdariffa Linn. (roselle) is a polyphenol rich fruit. This study aimed to identify the neuroprotective effect of
roselle on LPS-induced cell proliferation and nitric oxide-induced free radical in microglia and neuroblastoma cells.
MTT assay was used to identify the appropriate concentration of roselle and LPS for microglia and neuroblastoma cells
proliferation study. Griess assay were used to determine the level of nitric oxide accumulated based on the reaction of
Griess to estimate the activity of iNOS in nitric oxide production. The results showed that roselle at the concentration of
50 μg/mL and 100 μg/mL and LPS at concentration of 1 μg/mL does not give cytotoxic effect towards microglia C8-B4 and
neuroblastoma LN18 cells. The roselle treatment at 50 μg/mL and 100 μg/mL showed a protective effect on LPS-induced
microglia C8-B4 cells. However, in neuroblastoma LN18 cells, no protective effect was seen on both 50 μg/mL and 100
μg/mL of roselle treatment following induction with 1 μg/mL of LPS. On the other hand, the production of nitric oxide
(NO) was reduced when LPS-induced microglia C8-B4 cells were treated with 50 μg/mL of roselle. Treatment of roselle
at concentration 100 μg/mL on LPS-induced neuroblastoma LN18 cells also reduced the production of nitric oxide. As a
conclusion, roselle had the ability to give neuroprotective effect by the inhibition of LPS induction activity on microglia
activation for normal and cancer cells at different concentrations
Cognitive Behavioral Therapy (CBT) is a critical rehabilitation component for teens who involved in sexual offences. CBT restructures their reasoning capacity to control their anti-social behaviour. An in-depth qualitative study was conducted in one of the state’s institutions for girls to investigate the practice of CBT. Ten pregnant out of wedlock teens who were participate in the therapeutic rehabilitation programme were interviewed thoroughly about the practice of CBT. The study found that the practice of CBT in the programme focused only on the religious activities, tend to focus on the vocational programme, the absence of knowledge enhancement programme, no therapy expert to conduct the CBT procedure, and the absence of any set of protocol treatment for therapy. The findings then encourages the study to recommend few interventions that can enhance the implementation of the CBT practice for teens who involved with sex offence.
This is a follow-up study to assess the socio demographic profile of a sample of 28,605 women seeking pregnancy terminations at a private clinic in Penang over a seven year period as compared to an earlier study in 1995 of a sample of 23,986 women over a six and a half year period at the same clinic. This study was conducted using computerized patient medical records and paper reports generated from the computer data. The earlier 1995 study showed that the profile of a typical abortion client was a Chinese (60%), housewife (45%) in her late twenties (47%) with a monthly household income of less than RM1,200 (58%), having her first abortion (51%) and who had used contraception before (78%). For the seven year period from 1998-2005, the follow-up profile of a woman seeking an abortion in the same clinic in urban Malaysia was one with a monthly household income of less than RM2,000 (100%) in her late twenties (54%) who had used contraception in the past (85%). It is noted that the percentage of Malay respondents has increased (34%). The percentage of women who had a prior abortion at this clinic or elsewhere has also increased (68%), as compared to the preliminary study. Non-use of contraception remained an issue and traditional methods still outweighed the use of more effective contraceptive methods. In conclusion, fewer housewives and more Malay and Indonesian factory workers contributed to the clinic client profile over these seven years compared to that of the earlier study in 1995.
Motivation camp is one of the learning interventions to assist underperform students in improving their academic performances in term of GPA (Grade Point Average). An intervention study was carried out to know the effectiveness of a motivation camp in improving the academic performances among the biomedical science students at the Universiti Kebangsaan Malaysia, Kuala Lumpur. Total of 44 respondents were involved in this study from year 2 and year 3 and had been categorized into control and intervention groups (n = 22 per group). The intervention group was given motivational talks followed by a group discussion and self-reflection. The students in the intervention group were also assigned with academicians to facilitate and guide them throughout the motivational camp. The students were interested in motivational talks activity the most. The average GPA showed a significant improvement after the motivation camp with 3.01 ± 0.30 (p < 0.05) for the intervention group. Yet, control group also displayed a significant increment in the average GPA, 3.24 ± 0.06 (p < 0.05). In conclusion, motivation camp is one of the many learning intervention tools that strategize to help students in improving their academic performances but it should be complemented with other intervention methods.