MyMedR

Fulltext Layered double hydroxide nanocomposite for drug delivery systems; bio-distribution, toxicity and drug activity enhancement

Kura AU, Hussein MZ, Fakurazi S, Arulselvan P

Chem Cent J, 2014;8(1):47.

PMID: 25177361 DOI: 10.1186/s13065-014-0047-2

The production of layered double hydroxide(LDH) nanocomposite as an alternative drug delivery system against various ailments is on the increase. Their toxicity potential is usually dose and time dependent with particle sizes, shapes and surface charge playing some role both in the in vitro and in vivo studies. The reticular endothelial system of especially the liver and spleen were shown to sequestrate most of these nanocomposite, especially those with sizes greater than 50 nm. The intracellular drug delivery by these particles is mainly via endocytotic pathways aided by the surface charges in most cases. However, structural modification of these nanocomposite via coating using different types of material may lower the toxicity where present. More importantly, the coating may serve as targeting ligand hence, directing drug distribution and leading to proper drug delivery to specific area of need; it equally decreases the unwanted nanocomposite accumulation in especially the liver and spleen. These nanocomposite have the advantage of wider bio-distribution irrespective of route of administration, excellent targeted delivery potential with ease of synthetic modification including coating.

Fulltext Nanotechnology in drug delivery: the need for more cell culture based studies in screening

Kura AU, Fakurazi S, Hussein MZ, Arulselvan P

Chem Cent J, 2014;8:46.

PMID: 25057288 DOI: 10.1186/1752-153X-8-46

Advances in biomedical science are leading to upsurge synthesis of nanodelivery systems for drug delivery. The systems were characterized by controlled, targeted and sustained drug delivery ability. Humans are the target of these systems, hence, animals whose systems resembles humans were used to predict outcome. Thus, increasing costs in money and time, plus ethical concerns over animal usage. However, with consideration and planning in experimental conditions, in vitro pharmacological studies of the nanodelivery can mimic the in vivo system. This can function as a simple method to investigate the effect of such materials without endangering animals especially at screening phase.

Fulltext Effect of different drying techniques on flowability characteristics and chemical properties of natural carbohydrate-protein Gum from durian fruit seed

Mirhosseini H, Amid BT

Chem Cent J, 2013 Jan 04;7(1):1.

PMID: 23289739 DOI: 10.1186/1752-153X-7-1

BACKGROUND: A natural carbohydrate biopolymer was extracted from the agricultural biomass waste (durian seed). Subsequently, the crude biopolymer was purified by using the saturated barium hydroxide to minimize the impurities. Finally, the effect of different drying techniques on the flow characteristics and functional properties of the purified biopolymer was investigated. The present study elucidated the main functional characteristics such as flow characteristics, water- and oil-holding capacity, solubility, and foaming capacity.

RESULTS: In most cases except for oven drying, the bulk density decreased, thus increasing the porosity. This might be attributed to the increase in the inter-particle voids of smaller sized particles with larger contact surface areas per unit volume. The current study revealed that oven-dried gum and freeze-dried gum had the highest and lowest compressibility index, thus indicating the weakest and strongest flowability among all samples. In the present work, the freeze-dried gum showed the lowest angle of repose, bulk, tapped and true density. This indicates the highest porosity degree of freeze dried gum among dried seed gums. It also exhibited the highest solubility, and foaming capacity thus providing the most desirable functional properties and flow characteristics among all drying techniques.

CONCLUSION: The present study revealed that freeze drying among all drying techniques provided the most desirable functional properties and flow characteristics for durian seed gum.

Fulltext Corrosion inhibition properties of pyrazolylindolenine compounds on copper surface in acidic media

Ebadi M, Basirun WJ, Khaledi H, Ali HM

Chem Cent J, 2012 Dec 31;6(1):163.

PMID: 23276247 DOI: 10.1186/1752-153X-6-163

BACKGROUND: The corrosion inhibition performance of pyrazolylindolenine compounds, namely 4-(3,3-dimethyl-3H-indol-2-yl)-pyrazole-1-carbothioamide (InPzTAm), 4-(3,3-dimethyl-3H-indol-2-yl)-1H-pyrazole-1-carbothiohydrazide (InPzTH) and 3,3-dimethyl-2-(1-phenyl-1H-pyrazol-4-yl)-3H-indole (InPzPh),) on copper in 1M HCl solution is investigated by electrochemical impedance spectroscopy (EIS), open circuit potential (OCP) and linear scan voltammetry (LSV) techniques.

RESULTS: The results show that the corrosion rate of copper is diminished by the compounds with the inhibition strength in the order of: InPzTAm> InPzTH > InPzPh. The corrosion inhibition efficiencies for the three inhibitors are 94.0, 91.4 and 79.3, for InPzTAm, InPzTH and InPzPh respectively with the same inhibitor concentration (2 mM).

CONCLUSION: From the EIS, OCP and LSV results it was concluded that pyrazolylindolenine compounds with S-atom (with an amine group) have illustrated better corrosion inhibition performance compared to hydrazine and phenyl group.

Fulltext Gadolinium-based layered double hydroxide and graphene oxide nano-carriers for magnetic resonance imaging and drug delivery

Usman MS, Hussein MZ, Fakurazi S, Ahmad Saad FF

Chem Cent J, 2017 May 30;11(1):47.

PMID: 29086824 DOI: 10.1186/s13065-017-0275-3

Gadolinium (Gd)-based contrasts remain one of the most accepted contrast agents for magnetic resonance imaging, which is among the world most recognized noninvasive techniques employed in clinical diagnosis of patients. At ionic state, Gd is considered toxic but less toxic in chelate form. A variety of nano-carriers, including gadolinium oxide (Gd2O3) nanoparticles have been used by researchers to improve the T1 and T2 contrasts of MR images. Even more recently, a few researchers have tried to incorporate contrast agents simultaneously with therapeutic agents using single nano-carrier for theranostic applications. The benefit of this concept is to deliver the drugs, such as anticancer drugs and at the same time to observe what happens to the cancerous cells. The delivery of both agents occurs concurrently. In addition, the toxicity of the anticancer drugs as well as the contrast agents will be significantly reduced due to the presence of the nano-carriers. The use of graphene oxide (GO) and layered double hydroxides (LDH) as candidates for this purpose is the subject of current research, due to their low toxicity and biocompatibility, which have the capacity to be used in theranostic researches. We review here, some of the key features of LDH and GO for simultaneous drugs and diagnostic agents delivery systems for use in theranostics applications.

Fulltext Release behavior and toxicity profiles towards A549 cell lines of ciprofloxacin from its layered zinc hydroxide intercalation compound

Abdul Latip AF, Hussein MZ, Stanslas J, Wong CC, Adnan R

Chem Cent J, 2013;7:119.

PMID: 23849189 DOI: 10.1186/1752-153X-7-119

Layered hydroxides salts (LHS), a layered inorganic compound is gaining attention in a wide range of applications, particularly due to its unique anion exchange properties. In this work, layered zinc hydroxide nitrate (LZH), a family member of LHS was intercalated with anionic ciprofloxacin (CFX), a broad spectrum antibiotic via ion exchange in a mixture solution of water:ethanol.

Fulltext Stirring time effect of silver nanoparticles prepared in glutathione mediated by green method

Balavandy SK, Shameli K, Biak DR, Abidin ZZ

Chem Cent J, 2014;8(1):11.

PMID: 24524329 DOI: 10.1186/1752-153X-8-11

This study aims to investigate the influence of different stirring time for synthesis of silver nanoparticles in glutathione (GSH) aqueous solution. The silver nanoparticles (Ag-NPs) were prepared by green synthesis method using GSH as reducing agent and stabilizer, under moderate temperature at different stirring times. Silver nitrate (AgNO3) was taken as the metal precursor while Ag-NPs were prepared in the over reaction time.

Fulltext Biolubricant basestocks from chemically modified plant oils: ricinoleic acid based-tetraesters

Salih N, Salimon J, Yousif E, Abdullah BM

Chem Cent J, 2013;7(1):128.

PMID: 23885790 DOI: 10.1186/1752-153X-7-128

Plant oils have been investigated as a potential source of environmentally favorable biolubricants because of their biodegradability, renewability and excellent lubrication performance. Low oxidation and thermal stability, poor low-temperature properties and a narrow range of available viscosities, however, limit their potential application as industrial lubricants. The inherent problems of plant oils can be improved by attaching functional groups at the sites of unsaturation through chemical modifications. In this article, we will demonstrate how functionalization helps overcome these disadvantages.

Fulltext Design, synthesis and structural studies of meta-xylyl linked bis-benzimidazolium salts: potential anticancer agents against 'human colon cancer'

Haque RA, Iqbal MA, Khadeer Ahamed MB, Majid AA, Abdul Hameed ZA

Chem Cent J, 2012;6(1):68.

PMID: 22809051 DOI: 10.1186/1752-153X-6-68

Fulltext Interactions between photodegradation components

Abdollahi Y, Zakaria A, Matori KA, Shameli K, Jahangirian H, Rezayi M, et al.

Chem Cent J, 2012;6(1):100.

PMID: 22967885 DOI: 10.1186/1752-153X-6-100

The interactions of p-cresol photocatalytic degradation components were studied by response surface methodology. The study was designed by central composite design using the irradiation time, pH, the amount of photocatalyst and the p-cresol concentration as variables. The design was performed to obtain photodegradation % as actual responses. The actual responses were fitted with linear, two factor interactions, cubic and quadratic model to select an appropriate model. The selected model was validated by analysis of variance which provided evidences such as high F-value (845.09), very low P-value (

Fulltext Semi-empirical study of ortho-cresol photo degradation in manganese-doped zinc oxide nanoparticles suspensions

Abdollahi Y, Zakaria A, Abdullah AH, Fard Masoumi HR, Jahangirian H, Shameli K, et al.

Chem Cent J, 2012 Aug 21;6(1):88.

PMID: 22909072 DOI: 10.1186/1752-153X-6-88

The optimization processes of photo degradation are complicated and expensive when it is performed with traditional methods such as one variable at a time. In this research, the condition of ortho-cresol (o-cresol) photo degradation was optimized by using a semi empirical method. First of all, the experiments were designed with four effective factors including irradiation time, pH, photo catalyst's amount, o-cresol concentration and photo degradation % as response by response surface methodology (RSM). The RSM used central composite design (CCD) method consists of 30 runs to obtain the actual responses. The actual responses were fitted with the second order algebraic polynomial equation to select a model (suggested model). The suggested model was validated by a few numbers of excellent statistical evidences in analysis of variance (ANOVA). The used evidences include high F-value (143.12), very low P-value (<0.0001), non-significant lack of fit, the determination coefficient (R2 = 0.99) and the adequate precision (47.067). To visualize the optimum, the validated model simulated the condition of variables and response (photo degradation %) be using a few number of three dimensional plots (3D). To confirm the model, the optimums were performed in laboratory. The results of performed experiments were quite close to the predicted values. In conclusion, the study indicated that the model is successful to simulate the optimum condition of o-cresol photo degradation under visible-light irradiation by manganese doped ZnO nanoparticles.

Fulltext Optimization of reaction parameters in hydrothermal synthesis: a strategy towards the formation of CuS hexagonal plates

Auyoong YL, Yap PL, Huang X, Abd Hamid SB

Chem Cent J, 2013;7:67.

PMID: 23575312 DOI: 10.1186/1752-153X-7-67

For decades, copper sulphide has been renowned as the superior optical and semiconductor materials. Its potential applications can be ranged from solar cells, lithium-ion batteries, sensors, and catalyst systems. The synthesis methodologies of copper sulphide with different controlled morphology have been widely explored in the literature. Nevertheless, the understanding on the formation chemistry of CuS is still limited. The ultimate approach undertaking in this article is to investigate the formation of CuS hexagonal plates via the optimization of reaction parameters in hydrothermal reaction between copper (II) nitrate and sodium thiosulphate without appending any assistant agent.

Displaying publications 81 - 92 of 92 in total