MyMedR

HBeAG and anti-HBe in the Malaysian population and in Malaysian prisoners

Ton SH, Lopez CG, Noriah R

Southeast Asian J. Trop. Med. Public Health, 1983 Jun;14(2):252-4.

The incidence of HBsAg in random blood donors was found to be twice that of the prisoner population. The anti-HBe however, was about twice that in the prisoners when compared with the random blood donors. Both the random blood donors and the prisoners had similar incidence of HBeAg. The percentage frequency of HBsAg positivity with anti-HBe positivity was also similar in both groups. The 18 normal non-blood donors did not have HBsAg, HBeAg or anti-HBe.

Matched MeSH terms: Blood Donors*

Levels of plasma immunoglobulins in Malaysians

Shah FH, Yadav M

Southeast Asian J. Trop. Med. Public Health, 1973 Dec;4(4):468-73.

PMID: 4207078

Matched MeSH terms: Blood Donors

Organization of a blood transfusion service in tropical areas

Lopez CG

Southeast Asian J. Trop. Med. Public Health, 1979 Jun;10(2):177-83.

PMID: 524138

Matched MeSH terms: Blood Donors

Hepatitis B antigen in Kuala Lumpur blood donors

Kamath S, How VJ, Lam SK, Duraisamy G, Lopez CG, Welch Q

Southeast Asian J. Trop. Med. Public Health, 1973 Jun;4(2):159-64.

PMID: 4749067

Matched MeSH terms: Blood Donors*

Prevalence of anti-HBc in Malaysian male blood donors and its correlation with DNA polymerase activity

Ton SH, Lopez CG, Hasnah H

Southeast Asian J. Trop. Med. Public Health, 1979 Mar;10(1):1-6.

PMID: 483004

A study of Kuala Lumpur blood donors for HBsAG, anti-HBc and DNA polymeraes showed that 5.5% in the sample population was positive for HBsAG, 50.1% for anti-HBc and 10.1% for DNA polymerase activity. There was no significant difference of the HBsAG among the Malay, Chinese and Indian groups. However, a significant difference was observed for the anti-HBc and DNA polymerase activity between the Indian and the Malay/Chinese groups. Both analysis were significantly lower in the Indians but there was no significant difference between the Chinese and the Malays.

Matched MeSH terms: Blood Donors*

Seroreactivity to syphilis in Malaysian blood donors and expectant mothers

Jegathesan M, Fan YH, Ong KJ

Southeast Asian J. Trop. Med. Public Health, 1975 Sep;6(3):413-8.

PMID: 1241163

Seroreactivity to syphilis is high among Malaysian blood donors and expectant mothers indicating a high degree of treponemal infection. Further epidemiological studies are required to ascertain what proportion of these could be syphilis and what porportion yaws. Blood donors hava a higher reactivity rate than expectant mothers, the reasons probably being soical. The titres obtained in the VDRL test appear to have a relation to FTA-ABS reactivity although this is not to say treponematosis can be excluded on the basis of low titre VDRL results.

Matched MeSH terms: Blood Donors*

Prevalence of Helicobacter pylori infection among asymptomatic healthy blood donors in Northern Peninsular Malaysia

Sasidharan S, Uyub AM

Trans R Soc Trop Med Hyg, 2009 Apr;103(4):395-8.

PMID: 19211121 DOI: 10.1016/j.trstmh.2008.11.021

Helicobacter pylori infection is recognized as being strongly associated with chronic gastritis, duodenal ulceration and, probably, gastric carcinoma. Seroepidemiological studies have shown that a large proportion of healthy people have antibodies against H. pylori. A serological study was conducted in asymptomatic healthy blood donors in Northern Peninsular Malaysia to assess the seropositivity for H. pylori and to investigate the relationship with ethnic group, gender, ABO blood group and age. A total of 5370 serum samples collected from 3677 male and 1693 female donors in different age groups, and who had no gastrointestinal complaints, were studied with an in-house ELISA for the presence of H. pylori IgG and IgA antibodies. Seven hundred and sixty subjects (14.2%) were seropositive. The overall seropositivity did not differ with ethnicity, gender, ABO blood group and age among asymptomatic healthy blood donors in Northern Peninsular Malaysia.

Matched MeSH terms: Blood Donors*

Evaluation of serological transfusion-transmitted viral diseases and mutliplex nucleic acid testing in malaysian blood donors

Yaseen SG, Ahmed SA, Johan MF, Kiron R, Daher AM

Transfus Apher Sci, 2013 Dec;49(3):647-51.

PMID: 23890575 DOI: 10.1016/j.transci.2013.07.003

Transmission of infectious diseases is a recognized complication of blood transfusion and blood products. Nucleic acid testing (NAT) may contribute to improved efficiency of blood screening and thereby increase the safety margin for transfused blood.

Matched MeSH terms: Blood Donors*

Fulltext Effects of plateletpheresis on blood coagulation parameters in healthy donors at National Blood Centre, Kuala Lumpur, Malaysia

Siti Nadiah AK, Nor Asiah M, Nur Syimah AT, Normi M, Anza E, Aini AN, et al.

Transfus Apher Sci, 2013 Dec;49(3):507-10.

PMID: 24055412 DOI: 10.1016/j.transci.2013.08.004

Plateletpheresis is a method used to remove platelet from the body either from random volunteer donors, patient's family members or HLA matched donors. A cross sectional study was carried out on 59 plateletpheresis donors aged between 18 and 55 years at National Blood Center (NBC), Kuala Lumpur. We compared the blood parameters before and after plateletpheresis and we found that the platelet count, FVIII, fibrinogen and thrombophilia markers anti-thrombin (AT), protein C and protein S were significantly reduced (p<0.05) with prolonged PT and APTT. There were significant changes in blood coagulation parameters but it is within acceptable range.

Matched MeSH terms: Blood Donors*

Examining students' intention to perform voluntary blood donation using a theory of planned behaviour: A structural equation modelling approach

Hossain Parash M, Suki NM, Shimmi SC, Hossain ABMT, Murthy KD

Transfus Clin Biol, 2020 Apr;27(2):70-77.

PMID: 32139133 DOI: 10.1016/j.tracli.2020.02.002

OBJECTIVE: This study aims to examine the behavioural intention of students to make voluntary blood donations. Moreover, it uses a theory of planned behaviour as its guiding principle and does so within the context of Malaysia, a developing nation.

METHODS: Data were collected via a self-administered questionnaire from a sample of 500 students at a public higher learning institution in Malaysia. Structural equation modelling approach (SEM) was performed to assess the strength of the hypothesized relationships of the proposed model simultaneously via the two-stage model-building process.

RESULTS: The SEM approach revealed that knowledge was the most influential predictor of students' intention to make a voluntary blood donation. With the knowledge that the more blood they donate, the more lives will be saved, the inclination to donate blood is intensifying among students. Moreover, all of the TPB constructs applied were also seen to significantly influence students' response to voluntary blood donation.

CONCLUSIONS: The nexus of attitude, subjective norm, perceived behavioural control, and knowledge about students' intention to perform voluntary blood donation are evidenced in a developing nation. The implications of the study and directions for future research are provided.

Matched MeSH terms: Blood Donors*

Use of red blood cell indices for the identification of iron deficiency among blood donors

Nadarajan V, Sthaneshwar P, Eow GI

Transfus Med, 2008 Jun;18(3):184-9.

PMID: 18598281 DOI: 10.1111/j.1365-3148.2008.00862.x

The objective of this study was to identify haematological parameters useful in screening for iron deficiency among blood donors. Iron deficiency is a common complication of blood donation and often goes unrecognized until anaemia develops. Biochemical markers such as soluble transferrin receptor (TfR), ferritin and log(TfR/F) have been proposed as more valid indicators of body iron status. Red blood cell (RBC) parameters are, however, more easily measured and have also been proposed as indicators of iron depletion. We measured ferritin and TfR in 192 blood donors together with RBC analysis, performed on two haematology analysers. Thirteen donors had parameters suggestive of haemoglobinopathy and were excluded from further analysis. Overall, 10% (18/179) of the remaining donors had iron deficiency, as defined by log(TfR/F) exceeding the 95th percentile of the value in the population of first-time donors. Using receiver operating characteristic analysis, the sensitivity of ferritin was 100%, with a specificity of 90% at a cut-off of 15 mug L(-1). The sensitivity and specificity of RBC-Y at a cut-off of 152 for detecting iron deficiency were 81 and 89%, respectively. Haemoglobin content of reticulocytes, meanwhile, showed sensitivity of 69% and specificity of 93% when a cut-off of 28 pg was used. Both measures compare favourably with haemoglobin which only showed a sensitivity of 50%, although specificity was 91% at a cut-off value of 125 g L(-1). The parameter RBC-Y can be useful as a screening measure for iron deficiency in blood donors.

Matched MeSH terms: Blood Donors*

Hepatitis in renal transplant recipients with and without donor-specific blood transfusion

Morad Z, Suleiman AB, Kong CT

Transplant Proc, 1989 Feb;21(1 Pt 2):1825-6.

PMID: 2652593

Matched MeSH terms: Blood Donors

Fulltext Seroprevalence of anti-amoebic antibody among blood donors by indirect hemeagglutination assay

Zeehaida M, Zairi NZ, Tan ZN, Wong WK, Lim BH

Trop Biomed, 2009 Dec;26(3):366-8.

PMID: 20237453

The screening for anti-amoebic antibody among a group of donors was to obtain negative control serum samples for an on-going antigen development assay in diagnosis of amoebic liver abscess. Out of 200 samples, 125 (62.5%) were negative, whereas 44 (21.5%) had IHA titer of less than 1:128 and 31 (16.0%) of the samples had significant IHA titers of 1:128 or more, in which 2 serum samples gave titers of 1:4096.

Matched MeSH terms: Blood Donors*

Seroprevalence and molecular detection of Toxoplasma gondii in young healthy blood donors in Northern Iran

Kalantari N, Sheikhansari MR, Ghaffari S, Alipour J, Gorgani-Firouzjaee T, Tamadoni A, et al.

Trop Biomed, 2018 Dec 01;35(4):1017-1027.

PMID: 33601849

T. gondii is a life-threatening infection in immunocompromised patients which may be transmitted through blood transfusion. The present study aimed to evaluate the seroprevalence and molecular detection of T. gondii infection and the associated risk factors among young healthy blood donors in the central part of Mazandaran province, northern Iran. Blood samples were taken from 500 participants and the serum was separated. All serum samples were tested for the presence of anti-T. gondii antibodies (IgG) and then all positive samples were evaluated for IgM antibodies using commercial ELISA kits. All IgM positive samples and 66 randomly selected IgG positive samples were further tested by PCR of the REP-529 gene. Anti-Toxoplasma antibodies (IgG) avidity test was performed for 142 IgG positive samples which were randomly selected. In the current study, anti-T. gondii antibodies (IgG) and (IgM) were found in 316 (63.2%) and 3 (0.95 %) participants, respectively. Seropositivity rate of Toxoplasma was higher among blood donors living in rural areas (P=0.000) and those with a history of soil and animal contact (P<0.05). PCR of the REP-529 gene showed T. gondii DNA in 21 out of 66 samples. The REP-529 gene was not detected in IgM positive samples. Low avidity antibodies (IgG) was found in 23.2% of the IgG positive samples. In conclusions, this study found that the prevalence of toxoplasmosis among young healthy blood donors in north of Iran was high. To reduce the risk of parasite transmission, leukofilteration method are recommended for donated blood used for immunosuppressed patients.

Matched MeSH terms: Blood Donors

Seroprevalence of selected transfusion transmissible infections among blood donors in Region 3, Philippines: A 5-year retrospective study

Rivera NS, Tiongco REG, Salita CL, Kawano RL

Trop Biomed, 2019 Dec 01;36(4):993-1002.

PMID: 33597469

Transfusion of blood is a life-saving intervention that saves many lives. Unsafe practices in blood donation and pre-transfusion testing place people's lives at risk of transfusion transmissible infections (TTIs). The study aims to determine the overall seroprevalence of the selected TTIs for the past 5 years (2013-2017) among blood donors from a hospital in Region 3, Philippines. The trend and distribution of the TTIs according to age group, sex, donor category, and number of donations were also determined. Data extracted include the age, sex, donor category, number of donations, and screening results of all donors from January 2013 to December 2017. The overall seroprevalence of the selected TTIs from over the 5-year period is 4.17%. The seroprevalence rates of hepatitis B, hepatitis C, HIV and syphilis from 2013 to 2017 are 2.87%, 0.48%, 0.10%, and 0.62%, respectively. The age group of 25 to 44 years old showed the highest rate of reactive donors. Also, higher rates of reactive donors are seen among male donors, replacement donors, and first-time donors. The overall seroprevalence of TTIs in the study locale is low and it shows a decreasing trend from 2013 to 2017. Donors who are 25 to 44 years old, males, replacement, and first-time donors showed highest seroprevalence rates of TTIs.

Matched MeSH terms: Blood Donors*

Fulltext A systematic review of the epidemiology of Hepatitis E virus infection in South - Eastern Asia

Raji YE, Toung OP, Mohd Taib N, Sekawi ZB

Virulence, 2021 12;12(1):114-129.

PMID: 33372843 DOI: 10.1080/21505594.2020.1865716

Hepatitis E virus (HEV) infection is an emerging zoonotic viral disease, with an increasingly international public health challenge. Despite the concerns that the global disease burden may be underestimated. Therefore, evaluation of the disease epidemiology in South - eastern Asia through a systematic review will assist in unraveling the burden of the disease in the subregion. A priori protocol was prepared for the systematic review and followed by a literature search involving five electronic databases. Identified publications were screened for high quality studies and the elimination of bias and relevant data extracted. A total of 4157 citations were captured, and only 35 were included in the review. A wide range of HEV seroprevalence was recorded from 2% (urban blood donors in Malaysia) to 77.7% (lowland communities in Lao PDR). Sporadic HEV infection and epidemics were also detected in the subregion. Indicating hyperendemicity of the disease in South - eastern Asia.

Matched MeSH terms: Blood Donors*

Assessment of infectiousness of male Malaysian blood donors

So-Har T, Gladys LC, Ramli N

Vox Sang, 1983;45(5):389-91.

PMID: 6636661

HBeAg and anti-HBe were determined in the blood of 189 male blood donors. The incidence of HBsAg was 6.9% while that for HBeAg and anti-HBe was 1.6 and 18%, respectively. Of the 13 samples positive for HBsAg, two (15.4%) were positive for HBe while six (46.2%) were positive for anti-HBe. One specimen was negative for HBsAg but was positive for HBeAg and anti-HBe. The observations are discussed.

Matched MeSH terms: Blood Donors*

Displaying publications 81 - 97 of 97 in total