MyMedR

Fulltext Improving the management of brain injuries in Malaysian hospitals

Abdullah JM

Med J Malaysia, 2011 Jun;66(2):83.

Fulltext Neurosciences at Universiti Sains Malaysia Represent Malaysia to Support Global Precision Brain Health

Abdullah JM

Malays J Med Sci, 2019 May;26(3):1-23.

PMID: 31303847 DOI: 10.21315/mjms2019.26.3.1

The combined effort of the neuroscience and psychology cluster at the Universiti Sains Malaysia (USM)-fundamental, applied and clinical-has moved the institution to the number two position in the country, behind Universiti Malaya. The strategy to join the Global Brain Consortium (GBC) and put Malaysia on the map to address the GBC mission, vision, focus areas and outcomes began recently, in May 2019.

Fulltext Hominem Sine Opus Spatium: Where Do the Ideas Come from to Move the Brain, Mind, Behaviour and Neurosciences in Malaysia?

Abdullah JM

Malays J Med Sci, 2018 Mar;25(2):1-14.

PMID: 30918450 DOI: 10.21315/mjms2018.25.2.1

People can work wonders without a room. Rooms make people think within a box, and people who are not confined within a room can wonder while thinking and solve problems as they see them in the environment. The dearth in the growth of professionals trained in the neurosciences who will use neurotechnology in the future is a dire situation facing Malaysia, according to the Academy of Sciences Malaysia's 2017 Emerging Science, Engineering and Technology (ESET) study. Further, this human resource needs to be fundamentally cultivated at schools from a very young age. The author describes the activities that have taken place in the country via a bottom-up approach over the last two years and hopes that eventually these endeavours will end with the creation of an ASEAN Brain, Mind, Behaviour and Neuroscience Institute for Creativity and Innovation being established with the full support of the Government of Malaysia or other local and international financial donors.

All the Vice Chancellor's Neuroscientists: Unity to Achieve Success in Solving Malaysia's Diseases via Upgrading Clinical Services and Neuroscience Research

Abdullah JM

Malays J Med Sci, 2013 May;20(3):1-5.

PMID: 23966818

President Obama of the United States of America announced this April the Brain Research Through Advancing Innovative Neurotechnologies (BRAIN for short) investment, while Professor Henry Markram's team based in the European Union will spend over a billion euros on the Human Brain Project, breaking through the unknowns in the fifth science of the decade: Neuroscience. Malaysia's growth in the same field needs to be augmented, and thus the Universiti Sains Malaysia's vision is to excel in the field of clinical brain sciences, mind sciences and neurosciences. This will naturally bring up the level of research in the country simultaneously. Thus, a center was recently established to coordinate this venture. The four-year Integrated Neuroscience Program established recently will be a sustainable source of neuroscientists for the country. We hope to establish ourselves by 2020 as a global university with neurosciences research as an important flagship.

Fulltext Interesting asian plants: their compounds and effects on electrophysiology and behaviour

Abdullah JM

Malays J Med Sci, 2011 Oct;18(4):1-4.

PMID: 22589667 MyJurnal

There have been numerous non-scientific reports on the behavioural effects of Asian plants in humans who consumed these plants wholly or part thereof. Knowledge passed from generation to generation informs us of plants that increase effort and stamina, such as during paddy planting after the ingestion of Mitragyna speciosa Korth (ketum) as a tea supplement. Centella asiatica and Myristica fragrans are used as herbs to improve memory and to treat epilepsy, respectively. Zizyphus mauritiana is used to treat headache and burn pain, acts as an antitussive, and reduces rigor mortis immediately after death. These plants, which have been identified to exhibit analgaesic, muscle-relaxing, and nootropic effects, may contain important bio-compounds for medicinal chemistry and pharmaceutical research in Malaysia. The electrophysiology properties of these plants and their effects on epilepsy, behaviour, and pain will lead Malaysia to future new drug discoveries.

Progress in Clinical Neurosciences, Cognitive Neurosciences, Clinical Psychology, Neurotechnology and Brain Mapping in Malaysia

Abdullah JM

Malays J Med Sci, 2021 Apr;28(2):1-14.

PMID: 33958956 DOI: 10.21315/mjms2021.28.2.1

Last year, there was an increase in the amount of manpower in Malaysia, especially in terms of the numbers of neurosurgeons, cognitive neuroscientists and clinical psychologists. One way to increase the number of cognitive neurotechnologists in the country in 2021 is to allow neuroscientists to register as neurotechnologists with the Malaysian Board of Technologists (MBOT). The Malaysian Brain Mapping project has risen from its humble beginnings as an initiative of the Universiti Sains Malaysia Brain Mapping Group in 2017. There is currently a proposal for its entry into the national arena via the Precision Medicine Initiative with the Academy Science Malaysia, the Ministry of Science, Technology and Innovation, Ministry of Higher Education and Ministry of Health. The current Malaysian Government's Science, Technology, Innovation and Economy (STIE) plan was launched in 2020, leading to the establishment of neurotechnology as one of 10 STIE drivers.

The Eight Stages of Trust and "Amanah" in Medicine and the Dunning-Kruger effect

Abdullah JM

Malays J Med Sci, 2014 Jul;21(4):1-3.

PMID: 25977614

The Dunning-Kruger effect is a cognitive bias in which unskilled people make poor decisions and reach erroneous conclusions, but their incompetence denies them the metacognitive ability to recognise their mistakes. These unskilled people therefore suffer from illusory superiority, rating their ability as above average, much higher than it actually is, while the highly skilled underrate their own abilities, suffering from illusory inferiority.

Fulltext Neuroscience and Brain Science Special Issue begins in the Malaysian Journal of Medical Sciences

Abdullah JM

Malays J Med Sci, 2014 Dec;21(Spec Issue):1-5.

PMID: 25941457

The Malaysian Journal of Medical Sciences and the Orient Neuron Nexus have amalgated to publish a yearly special issue based on neuro- and brain sciences. This will hopefully improve the quality of peer-reviewed manuscripts in the field of fundamental, applied, and clinical neuroscience and brain science from Asian countries. One focus of the Universiti Sains Malaysia is to strengthen neuroscience and brain science, especially in the field of neuroinformatics.

Fulltext Ain't No Neuroscience Mountain High Enough: Experiences of a Neurogardener

Abdullah JM

Malays J Med Sci, 2015 May-Jun;22(3):1-6.

PMID: 26715890

16 years have passed since the idea was mooted in 1999 by five neurosurgeons in the corridors of Hotel Perdana, Kota Bharu. They were Dato' Dr Johari Siregar Bin Adnan, Dato' Professor Dr Ahmad Zubaidi Abdul Latif , Dr Azmin Kass Bin Rosman, Dato' Dr Mohammed Saffari Bin Mohammed Haspani and Professor Dato' Dr Jafri Malin Abdullah. They initiated the beginning of the first programme in Neurosurgery in Malaysia. The rest is history.

Another Important News from the Neuronman: Malaysia's Neuroscience Group Moves upwards in Terms of Research, Creativity, and Innovation

Abdullah JM

Malays J Med Sci, 2015 Dec;22(Spec Issue):1-4.

PMID: 27006631

12 months ago the first Neuroscience special issue of the Malaysia Journal of Medical Sciences was born with the intention to increase the number of local publication dedicated to neurosciences. Since then many events happened in the neuroscience world of Malaysia, those considered major were the establishment of a Neurotechnology Foresight 2050 task force by the Academy of Medicine Malaysia as well as the launching of Malaysia as the 18th member to join the International Neuroinformatics Coordinating Facility on the 9th October 2015 which was officiated by the Deputy Ministers of Higher Education, Datuk Mary Yap.

Fulltext Words from the current editor of MJMS

Abdullah JM

Malays J Med Sci, 2008 Oct;15(4):1.

PMID: 22589627

Fulltext Neurosciences in university sains malaysia; the way to go forward in malaysia with vision 2020

Abdullah JM

Malays J Med Sci, 2005 Jul;12(2):1-3.

PMID: 22605951

Fulltext Platelet alloantigen polymorphism and migraine headaches

Bhaskar S, Abdullah JM

Neurosciences (Riyadh), 2013 Apr;18(2):185-6.

PMID: 23545624

Intravascular hypothermia for acute hemorrhagic stroke: a pilot study

Abdullah JM, Husin A

Acta Neurochir. Suppl., 2011;111:421-4.

PMID: 21725794 DOI: 10.1007/978-3-7091-0693-8_72

The use of intravascular hypothermia in the treatment of hemorrhagic stroke is currently still being researched. The exact therapeutic properties and effect of hypothermia on the natural progression of the disease are not known, and a only small number of papers has been published with results from these studies. Mild hypothermia at 34°C was induced in six patients with hemorrhagic stroke in the first 48 h after presentation, using an intravascular catheter placed in the inferior vena cava. The hypothermia was induced and maintained for 24 h followed by gradual rewarming. Another 18 patients with hemorrhagic stroke but not receiving hypothermia were then taken as the control group, and all patients were treated with standard stroke management. The patients were then followed up using the modified Rankin Scale (mRS) for 6 months and 1 year. There was a statistically significant improvement at 6 months and 1 year follow-up using the mRS score in the hypothermia group, indicating a possible beneficial effect of early therapeutic hypothermia in the management of acute hemorrhagic stroke. However, a larger study is needed in order to confirm our finding.

The GABA A receptor subunits heterologously expressed in Xenopus oocytes

Abdullah JM, Zhang J

Mini Rev Med Chem, 2013 Apr 01;13(5):744-8.

PMID: 23373649

The γ-aminobutyric acid (GABA) A receptor is composed of a variety of subunits and combinations and shows a characteristic distribution in the CNS. To date, 20 subunits of the GABA A receptor have been cloned: α1-6, β1-4, γ1-3, δ, π, ε , Θ, and ρ1-3. Oocyte of Xenopus laevis is one of the most frequently used heterologous expression systems, which are used to design and analyze specific combinations of GABA A receptor subunits. In oocytes, a certain GABA A receptor function is studied only by comparing the amplitude of the response to GABA and other drugs by physiological and pharmacological methods. According to the studies on Xenopus laevis oocytes, the α1β2γ2S receptor combination is mostly used. The α1-containing receptors mediate sedative and anticonvulsant acts. The results of studies on oocytes show that PKA, NKCC1, P2X3 receptors, and GABA A receptor-associated protein, etc., are existing systems that show different reactivity to the GABA A receptors. The GABA A receptor subunits contain distinct binding sites for BZDs, neurosteroids, general anesthetics, etc., which are responsible for the numerous functions of the GABA A receptor. A variety of other drugs, such as topiramate, TG41, (+)- and (-)-borneol, apigenin, and 6-methylflavone could also have modulatory effects on the GABA A receptors. Some of the different models and hypotheses on GABA A receptor structure and function have been achieved by using the two-electrode voltage clamp method in oocytes.

Cervical Spine Deformity Correction: An Overview

Kandasamy R, Abdullah JM

World Neurosurg, 2016 07;91:640-1.

PMID: 27157281 DOI: 10.1016/j.wneu.2016.04.109

Optic nerve sheath diameter measurement: a means of detecting raised ICP in adult traumatic and non-traumatic neurosurgical patients

Raffiz M, Abdullah JM

Am J Emerg Med, 2017 Jan;35(1):150-153.

PMID: 27852525 DOI: 10.1016/j.ajem.2016.09.044

INTRODUCTION: Bedside ultrasound measurement of optic nerve sheath diameter (ONSD) is emerging as a non-invasive technique to evaluate and predict raised intracranial pressure (ICP). It has been shown in previous literature that ONSD measurement has good correlation with surrogate findings of raised ICP such as clinical and radiological findings suggestive of raised ICP.

OBJECTIVES: The objective of the study is to find a correlation between sonographic measurements of ONSD value with ICP value measured via the gold standard invasive intracranial ICP catheter, and to find the cut-off value of ONSD measurement in predicting raised ICP, along with its sensitivity and specificity value.

METHODS: A prospective observational study was performed using convenience sample of 41 adult neurosurgical patients treated in neurosurgical intensive care unit with invasive intracranial pressure monitoring placed in-situ as part of their clinical care. Portable SonoSite ultrasound machine with 7 MHz linear probe were used to measure optic nerve sheath diameter using the standard technique. Simultaneous ICP readings were obtained directly from the invasive monitoring.

RESULTS: Seventy-five measurements were performed on 41 patients. The non-parametric Spearman correlation test revealed a significant correlation at the 0.01 level between the ICP and ONSD value, with correlation coefficient of 0.820. The receiver operating characteristic curve generated an area under the curve with the value of 0.964, and with standard error of 0.22. From the receiver operating characteristic curve, we found that the ONSD value of 5.205 mm is 95.8% sensitive and 80.4% specific in detecting raised ICP.

CONCLUSIONS: ONSD value of 5.205 is sensitive and specific in detecting raised ICP. Bedside ultrasound measurement of ONSD is readily learned, and is reproducible and reliable in predicting raised ICP. This non-invasive technique can be a useful adjunct to the current invasive intracranial catheter monitoring, and has wide potential clinical applications in district hospitals, emergency departments and intensive care units.

Fulltext Malaysian Journal of Medical Sciences' Performance Status in 2018

Zulkapli NA, Abdullah JM

Malays J Med Sci, 2019 Jul;26(4):1-4.

PMID: 31496888 DOI: 10.21315/mjms2019.26.4.1

The Malaysian Journal of Medical Sciences (MJMS) would like to present a brief report of its progress in 2018 with a purpose to provide a clear picture of how it has performed so far. This report may considered as a helpful information, especially, to future authors who wish to submit their articles to MJMS. This report summarised the information of the total of original manuscripts received based on manuscript type, authors' country of origin and total of original manuscripts received by month. It also reveals the statistics of the final decisions made based on manuscript type, the accept-reject ratio by the editor and the time taken from submission to decision for all manuscripts submitted throughout 2018.

Telemetric EEG and the rat: a guide for neuroscientists

Abdullah JM, Rafiqul Islam M

Malays J Med Sci, 2012 Oct;19(4):1-5.

PMID: 23613643

Telemetric EEG in the rat's brain has been used for experiments which tests the effects of an antiepileptic compound on it's antiseizures activity. A simple classification correlating epileptiform discharge and Racine's behavioral activity is discussed.

Fulltext Breaking into the International Arena: Malaysian Journal of Medical Sciences publishing Report 2013

Ghazli NF, Abdullah JM

Malays J Med Sci, 2014 May;21(3):1-3.

PMID: 25246830

The most recent Malaysian Journal of Medical Sciences (MJMS)-MyCite report has shown that it has achieved a level becoming of a leading national medical science journal. This editorial reports on submission and acceptance rates of MJMS throughout the year 2013 and their geographical contributors. Our rejection rate of 29.76% with a 21.95% withdrawal rate because of poor quality of content and data as well as plagiarism indicates the seriousness of this journal to maintain the integrity and quality of it's scientific data.

Displaying publications 1 - 20 of 219 in total