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Fulltext Energy efficient optimal deployment of industrial wireless mesh networks using transient trigonometric Harris Hawks optimizer

Abdulrab H, Hussin FA, Ismail I, Assad M, Awang A, Shutari H, et al.

Heliyon, 2024 Apr 15;10(7):e28719.
PMID: 38596048 DOI: 10.1016/j.heliyon.2024.e28719

Wireless mesh networks (WMNs) play a vital role in modern communication systems, and optimizing the placement of wireless mesh routers is crucial for achieving efficient network performance in terms of coverage and connectivity. However, network congestion caused by overlapping routers poses challenges in WMN optimization. To address these issues, researchers have explored metaheuristic algorithms to strike a balance between coverage and connectivity in WMNs. This study introduces a novel hybrid optimization algorithm, namely Transient Trigonometric Harris Hawks Optimizer (TTHHO), specifically designed to tackle the optimization problems in WMNs. The primary objective of TTHHO is to find an optimal placement of routers that maximizes network coverage and ensures full connectivity among mesh routers. Notably, TTHHO's unique advantage lies in its efficient utilization of residual energy, strategically placing the sink node in areas with higher energy levels. The effectiveness of TTHHO is demonstrated through a comprehensive comparison with seven well-known algorithms, including Harris Hawks optimization (HHO), Sine Cosine Algorithm (SCA), Gray Wolf Optimization (GWO), Particle Swarm Optimization (PSO), Moth Flame Optimization (MFO), Equilibrium Optimizer (EO), and Transient Search Optimizer (TSO). The proposed algorithm is rigorously validated using 33 benchmark functions, and statistical analyses and simulation results confirm its superiority over other algorithms in terms of network connectivity, coverage, congestion reduction, and convergence. The simulation outcomes demonstrate the effectiveness and efficacy of the proposed TTHHO algorithm in optimizing WMNs, making it a promising approach for enhancing the performance of wireless communication systems.
Novel acyl hydrazide derivatives of polyhydroquinoline as potent anti-diabetic and anti-glycating agents: Synthesis, in vitro α-amylase, α-glucosidase inhibition and anti-glycating activity with molecular docking insights

Ur Rahman S, Alam A, Parveen Z, Zainab, Assad M, Adnan Ali Shah S, et al.

Bioorg Chem, 2024 Sep;150:107501.
PMID: 38865858 DOI: 10.1016/j.bioorg.2024.107501

In this study, eleven novel acyl hydrazides derivative of polyhydroquinoline were synthesized, characterized and screened for their in vitro anti-diabetic and anti-glycating activities. Seven compounds 2a, 2d, 2i, 2 h, 2j, 2f, and 2 g exhibited notable α-amylase inhibitory activity having IC50 values from 3.51 ± 2.13 to 11.92 ± 2.30 µM. Similarly, six compounds 2d, 2f, 2 h, 2i, 2j, and 2 g displayed potent α-glucosidase inhibitory activity compared to the standard acarbose. Moreover, eight derivatives 2d, 2 g, 2f, 2j, 2a, 2i, 2 g, and 2e showed excellent anti-glycating activity with IC50 values from 6.91 ± 2.66 to 15.80 ± 1.87 µM when compared them with the standard rutin (IC50 = 22.5 ± 0.90 µM). Molecular docking was carried out to predict the binding modes of all the compounds with α-amylase and α-glucosidase. The docking analysis revealed that most of the compounds established strong interactions with α-amylase and α-glucosidase. All compounds fitted well into the binding pockets of α-amylase and α-glucosidase. Among all compounds 2a and 2f were most potent based on docking score -8.2515 and -7.3949 against α-amylase and α-glucosidase respectively. These results hold promise for the development of novel candidates targeted at controlling postprandial glucose levels in individuals with diabetes.
Happiness among dentists: a multi-scale, multi-national study from 21 countries

Alhajj MN, Omar R, Khader Y, Celebić A, El Tantawi M, Folayan MO, et al.

Int Dent J, 2020 Oct;70(5):328-339.
PMID: 32501563 DOI: 10.1111/idj.12579

OBJECTIVES: The extent to which dentists are happy with their profession and their life has not been well studied. The present study aimed to explore the level of happiness, satisfaction with life and psychological well-being among a sample of dental professionals from 21 countries.
MATERIALS AND METHODS: The sample comprised 2,200 dentists from 21 countries. Three scales - Subjective Happiness Scale (SHS), Satisfaction With Life Scale (SWLS), and Affect Balance Scale (ABS) - were used to measure the subjective responses. Data related to demographic and social characteristics were recorded. Mann-Whitney and Kruskal-Wallis tests were used as appropriate. Scales were correlated, and multiple linear regression analyses were employed to identify the independent determinants of SHS, SWLS and ABS. Data were analysed using the SPSS software program; a value of P <0.05 was considered significant.
RESULTS: The overall mean scores of SHS, SWLS and ABS were 18.53 ± 5.06, 23.06 ± 6.25 and 1.26 ± 2.40, respectively, with significant differences found across countries: dentists working in Croatia, Peru and Serbia recorded the highest scores, unlike dentists practicing in Yemen, Syria, and Iraq, who recorded the lowest scores. There were significant, moderately positive correlations between the various scales: SHS and SWLS: r = 0.535, P

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