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The impact of Japanese nuclear wastewater discharge into the sea on the global economy: Input-output model approach

Wu X, Zhang Y, Feng X

Mar Pollut Bull, 2023 Jul;192:115067.
PMID: 37269704 DOI: 10.1016/j.marpolbul.2023.115067

As the division of work within the world economic system becomes increasingly complex, the impact of disturbing events on the economic system is expanding. Recently, Japan proposed to discharge nuclear wastewater into the Pacific Ocean, which will cause damage to marine fisheries, thereby seriously affecting fisheries and other industries in Japan and other countries and regions around the world. Considering different scenarios of final and intermediate demand shifting, this paper uses the Inoperability Input-Output Model (IIM) and Multi-Region Input-Output Model (MRIO) to simulate the economic consequences of nuclear wastewater discharge in Japan and calculate the economic changes of each industry and country (region). The results show that: In the short term, when only the final demand for Japanese fishery products decreases. (1) The ten countries (regions) with significant economic losses are Japan, the United States, Chinese Taipei, Canada, Chile, South Africa, Mexico, Peru, the United Kingdom, and Ireland. (2) The ten countries (regions) with a significant increase in total output due to demand shift are China (People's Republic of), the Rest of the World, India, Indonesia, Viet Nam, the Philippines, Brazil, Myanmar, the Russian Federation, and Malaysia. (3) A ranking of changes in the total output of different industries. In the long term, when both intermediate and final demand for Japanese fishery products decrease. (4) The change in value added in Japan. (5) The change in value added of 67 countries (regions) worldwide. The ten countries (regions) with the most significant increase in value-added are the Russian Federation, China (People's Republic of), the Rest of the World, the United States, Indonesia, Australia, Norway, Korea, Viet Nam, and Myanmar. The ten countries (regions) with the most significant decrease in value-added are Japan, Chinese Taipei, Chile, South Africa, Peru, Thailand, Mexico, Cambodia, Costa Rica, and Morocco. Changes in value added of 45 industrial sectors worldwide.
Total Synthesis of (-)-Conolutinine

Feng X, Jiang G, Xia Z, Hu J, Wan X, Gao JM, et al.

Org. Lett., 2015 Sep 18;17(18):4428-31.
PMID: 26315849 DOI: 10.1021/acs.orglett.5b02046

The first enantioselective synthesis of (-)-conolutinine was achieved in 10 steps. The synthesis featured a catalytic asymmetric bromocyclization of tryptamine to forge the tricycle intermediate. Hydration of an alkene catalyzed by Co(acac)2 was also employed as a key step to diastereoselectively introduce the tertiary alcohol moiety. The absolute configuration of (-)-conolutinine was established to be (2S,5aS,8aS,13aR) based on this asymmetric total synthesis.
Evaluation of the inhibitory effects of drugs on the growth of Babesia gibsoni using relative quantification real-time PCR

He WH, Feng XX, Wu X, Zhai XH, Li YY, Zhang B, et al.

Trop Biomed, 2020 Dec 01;37(4):871-876.
PMID: 33612740 DOI: 10.47665/tb.37.4.871

To evaluate the inhibitory effects of drugs on the growth of Babesia gibsoni, relative quantification real-time PCR method was developed in this study. The 18S rRNA gene was used as a target gene for the 2-ΔΔCt method analysis. Additionally, chicken RNA was added to the parasitized blood before total RNA extraction. The chicken β-actin gene was selected as an internal control gene for the 2-ΔΔCt method analysis. The 100 µL parasitized blood samples with different percentages of parasitized erythrocytes (PPEs) (3%, 1.5%, 0.75%, 0.375% and 0.1875%) were prepared for relative quantification of B. gibsoni. Regression analysis results revealed significant linear relationships between the relative quantification value and parasitemia. 18S rRNA gene expression was significantly decreased after treatment with diminazene aceturate and artesunate in vitro drug sensitivity test. This result suggested that this relative quantification real-time PCR method can be used to evaluate the effects of drug inhibition.
Multifunctional Lanthanide Metal-Organic Frameworks Based on -NH2 Modified Ligand: Fluorescent Ratio Probe, CrO42- Ions Adsorption, and Photocatalytic Property

Chen X, Feng X, Zhang Z, Deng X, Dai F, Zhang L, et al.

Inorg Chem, 2023 Oct 02;62(39):16170-16181.
PMID: 37722103 DOI: 10.1021/acs.inorgchem.3c02448

In response to the growing concern for environmental pollution, two lanthanide compounds {[Ln(L)(H2O)]·4H2O}n (where Ln = Tb and Gd, H3L = 1-amino-2,4,6-benzene tricarboxylic acid) were synthesized using a -NH2 modified ligand and systematically characterized. Both compounds exhibit remarkable fluorescence response, adsorption of CrO42- ions, and photocatalytic degradation properties, as well as exceptional acid-base and thermal stability. Remarkably, the pH-dependent 1-Tb exhibits exceptional performance as a fluorescent probe for detecting Fe3+ and CrO42-/Cr2O72- ions in aqueous solutions, while also serving as a ratiometric fluorescent probe for the detection of Cr3+, offering rapid response, high sensitivity, selectivity, and recoverability advantages in application. Moreover, 1-Tb exhibits excellent detection capabilities and displays effective adsorption of CrO42- ions, with a maximum adsorption capacity of 230.71 mg/g. On the other hand, 1-Gd exhibits superior performance compared to 1-Tb in the photocatalytic degradation of antibiotics. The degradation mechanism is further elucidated by conducting experiments with DFT theoretical calculations.
A series of anionic host coordination polymers based on azoxybenzene carboxylate: structures, luminescence and magnetic properties

Feng X, Guo N, Chen H, Wang H, Yue L, Chen X, et al.

Dalton Trans, 2017 Oct 24;46(41):14192-14200.
PMID: 28990615 DOI: 10.1039/c7dt02974h

A series of coordination polymers {[Ln(aobtc)(H2O)4]·Hbipy·H2O}n (H4aobtc = azoxybenzene-2,2',3,3'-tetracarboxylic acid, bipy = 4,4'-bipyridine, and Ln = Sm(1), Eu(2), Gd(3), Tb(4), Dy(5), Er(6)) have been synthesized and characterized systematically. The cationic Hbipy(+) guest incorporated polymers are isostructural sets, featuring a one-dimensional (1D) zigzag double chain edifice composed of binuclear clusters [Ln2(H4aobtc)2], with the Hbipy(+) guest being located on two sides. These 1D chains are further interlinked into a 2D layer structure, and further extended into a 3D framework through hydrogen bonding interactions. The luminescence emission spectra of polymers 2 and 3 are based on the H4aobtc acid ligands, while 1 and 4 display the characteristic f-f transitions of Ln(iii) ions. Magnetic measurements revealed the presence of ferromagnetic behavior in polymer 3. The magnetic behaviors of 4 and 6 are ascribed to the depopulation of the Stark levels and/or weak antiferromagnetic interactions within MOFs at lower temperature. Slow relaxation is observed through the alternating-current susceptibility measurements for 5 at lower temperature, and the coexistence of weak ferromagnetism corresponding to the spin-canting-like behavior.
Purification of Plasmodium and Babesia- infected erythrocytes using a non-woven fabric filter

Tao ZY, Liu WP, Dong J, Feng XX, Yao DW, Lv QL, et al.

Trop Biomed, 2020 Dec 01;37(4):911-918.
PMID: 33612745 DOI: 10.47665/tb.37.4.911

The purification of parasite-infected erythrocytes from whole blood containing leucocytes is crucial for many downstream genetic and molecular assays in parasitology. Current methodologies to achieve this are often costly and time consuming. Here, we demonstrate the successful application of a cheap and simple Non-Woven Fabric (NWF) filter for the purification of parasitized red blood cells from whole blood. NWF filtration was applied to the malaria-parasitized blood of three strains of mice, and one strain of rat, and to Babesia gibsoni parasitized dog blood. Before and after filtration, the white blood cell (WBC) removal rates and red blood cell (RBC) recovery rates were measured. After NWF filter treatment of rodent malaria-infected blood, the WBC removal rates and RBC recovery rates were, for Kunming mice: 99.51%±0.30% and 86.12%±8.37%; for BALB/C mice: 99.61%±0.15% and 80.74%±7.11%; for C57 mice: 99.71%±0.12% and 84.87%±3.83%; for Sprague-Dawley rats: 99.93%±0.03% and 83.30%±2.96%. Microscopy showed WBCs were efficiently removed from infected dog blood samples, and there was no obvious morphological change of B. gibsoni parasites. NWF filters efficiently remove leukocytes from malaria parasite-infected mouse and rat blood, and are also suitable for filtration of B. gibsoni-infected dog blood.
Utilising standard samples instead of randomly collected food waste in composting: Implementation strategy and feasibility evaluation

Wang J, Li C, Awasthi MK, Nyambura SM, Zhu Z, Li H, et al.

J Environ Manage, 2024 Feb 27;353:120182.
PMID: 38278112 DOI: 10.1016/j.jenvman.2024.120182

Randomly collected food waste results in inaccurate experimental data with poor reproducibility for composting. This study investigated standard food waste samples as replacements for randomly collected food waste. A response surface methodology was utilised to analyse data from a 28-day compost process optimisation experiment using collected food waste, and the optimal combination of composting parameters was derived. Experiments using different standard food waste samples (high oil and salt, high oil and sugar, balanced diet, and vegetarian) were conducted for 28 days under optimal conditions. The ranking of differences between the standard samples and collected food waste was vegetarian > balanced diet > high oil and sugar > high oil and salt. Statistical analysis indicated t-tests for increased oil and salt samples and collected food waste were not significant, and Cohen's d effect values were minimal. High oil and salt samples can be used as replacements for collected food waste in composting experiments.
Differences Between Pulmonary and Extrapulmonary Pediatric Acute Respiratory Distress Syndrome: A Multicenter Analysis

Gan CS, Wong JJ, Samransamruajkit R, Chuah SL, Chor YK, Qian S, et al.

Pediatr Crit Care Med, 2018 10;19(10):e504-e513.
PMID: 30036234 DOI: 10.1097/PCC.0000000000001667

OBJECTIVES: Extrapulmonary pediatric acute respiratory distress syndrome and pulmonary pediatric acute respiratory distress syndrome are poorly described in the literature. We aimed to describe and compare the epidemiology, risk factors for mortality, and outcomes in extrapulmonary pediatric acute respiratory distress syndrome and pulmonary pediatric acute respiratory distress syndrome.
DESIGN: This is a secondary analysis of a multicenter, retrospective, cohort study. Data on epidemiology, ventilation, therapies, and outcomes were collected and analyzed. Patients were classified into two mutually exclusive groups (extrapulmonary pediatric acute respiratory distress syndrome and pulmonary pediatric acute respiratory distress syndrome) based on etiologies. Primary outcome was PICU mortality. Cox proportional hazard regression was used to identify risk factors for mortality.
SETTING: Ten multidisciplinary PICUs in Asia.
PATIENTS: Mechanically ventilated children meeting the Pediatric Acute Lung Injury Consensus Conference criteria for pediatric acute respiratory distress syndrome between 2009 and 2015.
INTERVENTIONS: None.
MEASUREMENTS AND MAIN RESULTS: Forty-one of 307 patients (13.4%) and 266 of 307 patients (86.6%) were classified into extrapulmonary pediatric acute respiratory distress syndrome and pulmonary pediatric acute respiratory distress syndrome groups, respectively. The most common causes for extrapulmonary pediatric acute respiratory distress syndrome and pulmonary pediatric acute respiratory distress syndrome were sepsis (82.9%) and pneumonia (91.7%), respectively. Children with extrapulmonary pediatric acute respiratory distress syndrome were older, had higher admission severity scores, and had a greater proportion of organ dysfunction compared with pulmonary pediatric acute respiratory distress syndrome group. Patients in the extrapulmonary pediatric acute respiratory distress syndrome group had higher mortality (48.8% vs 24.8%; p = 0.002) and reduced ventilator-free days (median 2.0 d [interquartile range 0.0-18.0 d] vs 19.0 d [0.5-24.0 d]; p = 0.001) compared with the pulmonary pediatric acute respiratory distress syndrome group. After adjusting for site, severity of illness, comorbidities, multiple organ dysfunction, and severity of acute respiratory distress syndrome, extrapulmonary pediatric acute respiratory distress syndrome etiology was not associated with mortality (adjusted hazard ratio, 1.56 [95% CI, 0.90-2.71]).
CONCLUSIONS: Patients with extrapulmonary pediatric acute respiratory distress syndrome were sicker and had poorer clinical outcomes. However, after adjusting for confounders, it was not an independent risk factor for mortality.
Fulltext The temporal trend of disease burden attributable to metabolic risk factors in China, 1990-2019: An analysis of the Global Burden of Disease study

Jin Y, So H, Cerin E, Barnett A, Mubarik S, Hezam K, et al.

Front Nutr, 2022;9:1035439.
PMID: 36687675 DOI: 10.3389/fnut.2022.1035439

BACKGROUND AND AIMS: The disease burden attributable to metabolic risk factors is rapidly increasing in China, especially in older people. The objective of this study was to (i) estimate the pattern and trend of six metabolic risk factors and attributable causes in China from 1990 to 2019, (ii) ascertain its association with societal development, and (iii) compare the disease burden among the Group of 20 (G20) countries.
METHODS: The main outcome measures were disability-adjusted life-years (DALYs) and mortality (deaths) attributable to high fasting plasma glucose (HFPG), high systolic blood pressure (HSBP), high low-density lipoprotein (HLDL) cholesterol, high body-mass index (HBMI), kidney dysfunction (KDF), and low bone mineral density (LBMD). The average annual percent change (AAPC) between 1990 and 2019 was analyzed using Joinpoint regression.
RESULTS: For all six metabolic risk factors, the rate of DALYs and death increased with age, accelerating for individuals older than 60 and 70 for DALYs and death, respectively. The AAPC value in rate of DALYs and death were higher in male patients than in female patients across 20 age groups. A double-peak pattern was observed for AAPC in the rate of DALYs and death, peaking at age 20-49 and at age 70-95 plus. The age-standardized rate of DALYs increased for HBMI and LBMD, decreased for HFPG, HSBP, KDF, and remained stable for HLDL from 1990 to 2019. In terms of age-standardized rate of DALYs, there was an increasing trend of neoplasms and neurological disorders attributable to HFPG; diabetes and kidney diseases, neurological disorders, sense organ diseases, musculoskeletal disorders, neoplasms, cardiovascular diseases, digestive diseases to HBMI; unintentional injuries to LBMD; and musculoskeletal disorders to KDF. Among 19 countries of Group 20, in 2019, the age-standardized rate of DALYs and death were ranked fourth to sixth for HFPG, HSBP, and HLDL, but ranked 10th to 15th for LBMD, KDF, and HBMI, despite the number of DALYs and death ranked first to second for six metabolic risk factors.
CONCLUSIONS: Population aging continuously accelerates the metabolic risk factor driven disease burden in China. Comprehensive and tight control of metabolic risk factors before 20 and 70 may help to mitigate the increasing disease burden and achieve healthy aging, respectively.
Fulltext Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, et al.

Nat Commun, 2018 07 09;9(1):2372.
PMID: 29985391 DOI: 10.1038/s41467-018-04590-1

Dysregulation of the Hippo signaling pathway and the consequent YAP1 activation is a frequent event in human malignancies, yet the underlying molecular mechanisms are still poorly understood. A pancancer analysis of core Hippo kinases and their candidate regulating molecules revealed few alterations in the canonical Hippo pathway, but very frequent genetic alterations in the FAT family of atypical cadherins. By focusing on head and neck squamous cell carcinoma (HNSCC), which displays frequent FAT1 alterations (29.8%), we provide evidence that FAT1 functional loss results in YAP1 activation. Mechanistically, we found that FAT1 assembles a multimeric Hippo signaling complex (signalome), resulting in activation of core Hippo kinases by TAOKs and consequent YAP1 inactivation. We also show that unrestrained YAP1 acts as an oncogenic driver in HNSCC, and that targeting YAP1 may represent an attractive precision therapeutic option for cancers harboring genomic alterations in the FAT1 tumor suppressor genes.