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  1. Romero-Güiza MS, Wahid R, Hernández V, Møller H, Fernández B
    Sci Total Environ, 2017 Oct 01;595:651-659.
    PMID: 28402918 DOI: 10.1016/j.scitotenv.2017.04.006
    Lignocellulosic biomasses such as wheat straw are widely used as a feedstock for biogas production. However, these biomasses are mainly composed of a compact fibre structure and therefore, it is recommended to treat them prior to its usage for biogas production in order to improve their bioavailability. The aim of this work is to evaluate, in terms of performance stability, methane yield and economic feasibility, two different scenarios: a mesophilic codigestion of wheat straw and animal manure with or without a low-energy demand alkaline pre-treatment (0.08gKOHgTS-1of wheat straw, for 24h and at 25°C). Besides this, said pre-treatment was also analysed based on the improvement of the bioavailable carbohydrate content in the untreated versus the pre-treated wheat straw. The results pointed out that pre-treated wheat straw prompted a more stable performance (in terms of pH and alkalinity) and an improved methane yield (128% increment) of the mesophilic codigestion process, in comparison to the "untreated" scenario. The pre-treatment increased the content of cellulose, hemicellulose and other compounds (waxes, pectin, oil, etc.) in the liquid fraction, from 5% to 60%, from 11.5% to 39.1% TS and from 57% to 79% of the TS in the liquid fraction for the untreated and pre-treated wheat straws, respectively. Finally, the pre-treated scenario gained an energy surplus of a factor 13.5 and achieved a positive net benefit of 90.4€tVS-WS-1d-1, being a favourable case for an eventual scale-up of the combined process.
  2. Ravšelj D, Keržič D, Tomaževič N, Umek L, Brezovar N, A Iahad N, et al.
    PLoS One, 2025;20(2):e0315011.
    PMID: 39908277 DOI: 10.1371/journal.pone.0315011
    The paper presents the most comprehensive and large-scale global study to date on how higher education students perceived the use of ChatGPT in early 2024. With a sample of 23,218 students from 109 countries and territories, the study reveals that students primarily used ChatGPT for brainstorming, summarizing texts, and finding research articles, with a few using it for professional and creative writing. They found it useful for simplifying complex information and summarizing content, but less reliable for providing information and supporting classroom learning, though some considered its information clearer than that from peers and teachers. Moreover, students agreed on the need for AI regulations at all levels due to concerns about ChatGPT promoting cheating, plagiarism, and social isolation. However, they believed ChatGPT could potentially enhance their access to knowledge and improve their learning experience, study efficiency, and chances of achieving good grades. While ChatGPT was perceived as effective in potentially improving AI literacy, digital communication, and content creation skills, it was less useful for interpersonal communication, decision-making, numeracy, native language proficiency, and the development of critical thinking skills. Students also felt that ChatGPT would boost demand for AI-related skills and facilitate remote work without significantly impacting unemployment. Emotionally, students mostly felt positive using ChatGPT, with curiosity and calmness being the most common emotions. Further examinations reveal variations in students' perceptions across different socio-demographic and geographic factors, with key factors influencing students' use of ChatGPT also being identified. Higher education institutions' managers and teachers may benefit from these findings while formulating the curricula and instructions/regulations for ChatGPT use, as well as when designing the teaching methods and assessment tools. Moreover, policymakers may also consider the findings when formulating strategies for secondary and higher education system development, especially in light of changing labor market needs and related digital skills development.
  3. Nguyen TN, Qureshi MM, Klein P, Yamagami H, Abdalkader M, Mikulik R, et al.
    J Stroke, 2022 May;24(2):256-265.
    PMID: 35677980 DOI: 10.5853/jos.2022.00752
    BACKGROUND AND PURPOSE: Recent studies suggested an increased incidence of cerebral venous thrombosis (CVT) during the coronavirus disease 2019 (COVID-19) pandemic. We evaluated the volume of CVT hospitalization and in-hospital mortality during the 1st year of the COVID-19 pandemic compared to the preceding year.

    METHODS: We conducted a cross-sectional retrospective study of 171 stroke centers from 49 countries. We recorded COVID-19 admission volumes, CVT hospitalization, and CVT in-hospital mortality from January 1, 2019, to May 31, 2021. CVT diagnoses were identified by International Classification of Disease-10 (ICD-10) codes or stroke databases. We additionally sought to compare the same metrics in the first 5 months of 2021 compared to the corresponding months in 2019 and 2020 (ClinicalTrials.gov Identifier: NCT04934020).

    RESULTS: There were 2,313 CVT admissions across the 1-year pre-pandemic (2019) and pandemic year (2020); no differences in CVT volume or CVT mortality were observed. During the first 5 months of 2021, there was an increase in CVT volumes compared to 2019 (27.5%; 95% confidence interval [CI], 24.2 to 32.0; P<0.0001) and 2020 (41.4%; 95% CI, 37.0 to 46.0; P<0.0001). A COVID-19 diagnosis was present in 7.6% (132/1,738) of CVT hospitalizations. CVT was present in 0.04% (103/292,080) of COVID-19 hospitalizations. During the first pandemic year, CVT mortality was higher in patients who were COVID positive compared to COVID negative patients (8/53 [15.0%] vs. 41/910 [4.5%], P=0.004). There was an increase in CVT mortality during the first 5 months of pandemic years 2020 and 2021 compared to the first 5 months of the pre-pandemic year 2019 (2019 vs. 2020: 2.26% vs. 4.74%, P=0.05; 2019 vs. 2021: 2.26% vs. 4.99%, P=0.03). In the first 5 months of 2021, there were 26 cases of vaccine-induced immune thrombotic thrombocytopenia (VITT), resulting in six deaths.

    CONCLUSIONS: During the 1st year of the COVID-19 pandemic, CVT hospitalization volume and CVT in-hospital mortality did not change compared to the prior year. COVID-19 diagnosis was associated with higher CVT in-hospital mortality. During the first 5 months of 2021, there was an increase in CVT hospitalization volume and increase in CVT-related mortality, partially attributable to VITT.

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