Displaying publications 1 - 20 of 28 in total

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  1. Abd Rahman NH, Ibrahim AK, Hasikin K, Abd Razak NA
    J Healthc Eng, 2023;2023:3136511.
    PMID: 36860328 DOI: 10.1155/2023/3136511
    Medical device reliability is the ability of medical devices to endure functioning and is indispensable to ensure service delivery to patients. Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) technique was employed in May 2021 to evaluate existing reporting guidelines on medical device reliability. The systematic searching is conducted in eight different databases, including Web of Science, Science Direct, Scopus, IEEE Explorer, Emerald, MEDLINE Complete, Dimensions, and Springer Link, with 36 articles shortlisted from the year 2010 to May 2021. This study aims to epitomize existing literature on medical device reliability, scrutinize existing literature outcomes, investigate parameters affecting medical device reliability, and determine the scientific research gaps. The result of the systematic review listed three main topics on medical device reliability: risk management, performance prediction using Artificial Intelligence or machine learning, and management system. The medical device reliability assessment challenges are inadequate maintenance cost data, determining significant input parameter selection, difficulties accessing healthcare facilities, and limited age in service. Medical device systems are interconnected and interoperating, which increases complexity in assessing their reliability. To the best of our knowledge, although machine learning has become popular in predicting medical device performance, the existing models are only applicable to selected devices such as infant incubators, syringe pumps, and defibrillators. Despite the importance of medical device reliability assessment, there is no explicit protocol and predictive model to anticipate the situation. The problem worsens with the unavailability of a comprehensive assessment strategy for critical medical devices. Therefore, this study reviews the current state of critical device reliability in healthcare facilities. The present knowledge can be improved by adding new scientific data emphasis on critical medical devices used in healthcare services.
  2. Zamzam AH, Abdul Wahab AK, Azizan MM, Satapathy SC, Lai KW, Hasikin K
    Front Public Health, 2021;9:753951.
    PMID: 34646808 DOI: 10.3389/fpubh.2021.753951
    Medical equipment highly contributes to the effectiveness of healthcare services quality. Generally, healthcare institutions experience malfunctioning and unavailability of medical equipment that affects the healthcare services delivery to the public. The problems are frequently due to a deficiency in managing and maintaining the medical equipment condition by the responsible party. The assessment of the medical equipment condition is an important activity during the maintenance and management of the equipment life cycle to increase availability, performance, and safety. The study aimed to perform a systematic review in extracting and categorising the input parameters applied in assessing the medical equipment condition. A systematic searching was undertaken in several databases, including Web of Science, Scopus, PubMed, Science Direct, IEEE Xplore, Emerald, Springer, Medline, and Dimensions, from 2000 to 2020. The searching processes were conducted in January 2020. A total of 16 articles were included in this study by adopting Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA). The review managed to classify eight categories of medical equipment reliability attributes, namely equipment features, function, maintenance requirement, performance, risk and safety, availability and readiness, utilisation, and cost. Applying the eight attributes extracted from computerised asset maintenance management system will assist the clinical engineers in assessing the reliability of medical equipment utilised in healthcare institution. The reliability assessment done in these eight attributes will aid clinical engineers in executing a strategic maintenance action, which can increase the equipment's availability, upkeep the performance, optimise the resources, and eventually contributes in providing effective healthcare service to the community. Finally, the recommendations for future works are presented at the end of this study.
  3. Khalil A, Rahimi A, Luthfi A, Azizan MM, Satapathy SC, Hasikin K, et al.
    Front Public Health, 2021;9:752509.
    PMID: 34621723 DOI: 10.3389/fpubh.2021.752509
    A process that involves the registration of two brain Magnetic Resonance Imaging (MRI) acquisitions is proposed for the subtraction between previous and current images at two different follow-up (FU) time points. Brain tumours can be non-cancerous (benign) or cancerous (malignant). Treatment choices for these conditions rely on the type of brain tumour as well as its size and location. Brain cancer is a fast-spreading tumour that must be treated in time. MRI is commonly used in the detection of early signs of abnormality in the brain area because it provides clear details. Abnormalities include the presence of cysts, haematomas or tumour cells. A sequence of images can be used to detect the progression of such abnormalities. A previous study on conventional (CONV) visual reading reported low accuracy and speed in the early detection of abnormalities, specifically in brain images. It can affect the proper diagnosis and treatment of the patient. A digital subtraction technique that involves two images acquired at two interval time points and their subtraction for the detection of the progression of abnormalities in the brain image was proposed in this study. MRI datasets of five patients, including a series of brain images, were retrieved retrospectively in this study. All methods were carried out using the MATLAB programming platform. ROI volume and diameter for both regions were recorded to analyse progression details, location, shape variations and size alteration of tumours. This study promotes the use of digital subtraction techniques on brain MRIs to track any abnormality and achieve early diagnosis and accuracy whilst reducing reading time. Thus, improving the diagnostic information for physicians can enhance the treatment plan for patients.
  4. Yeoh PSQ, Lai KW, Goh SL, Hasikin K, Hum YC, Tee YK, et al.
    Comput Intell Neurosci, 2021;2021:4931437.
    PMID: 34804143 DOI: 10.1155/2021/4931437
    Osteoarthritis (OA), especially knee OA, is the most common form of arthritis, causing significant disability in patients worldwide. Manual diagnosis, segmentation, and annotations of knee joints remain as the popular method to diagnose OA in clinical practices, although they are tedious and greatly subject to user variation. Therefore, to overcome the limitations of the commonly used method as above, numerous deep learning approaches, especially the convolutional neural network (CNN), have been developed to improve the clinical workflow efficiency. Medical imaging processes, especially those that produce 3-dimensional (3D) images such as MRI, possess ability to reveal hidden structures in a volumetric view. Acknowledging that changes in a knee joint is a 3D complexity, 3D CNN has been employed to analyse the joint problem for a more accurate diagnosis in the recent years. In this review, we provide a broad overview on the current 2D and 3D CNN approaches in the OA research field. We reviewed 74 studies related to classification and segmentation of knee osteoarthritis from the Web of Science database and discussed the various state-of-the-art deep learning approaches proposed. We highlighted the potential and possibility of 3D CNN in the knee osteoarthritis field. We concluded by discussing the possible challenges faced as well as the potential advancements in adopting 3D CNNs in this field.
  5. Jusman Y, Mat Isa NA, Ng SC, Hasikin K, Abu Osman NA
    J Biomed Opt, 2016 07 01;21(7):75005.
    PMID: 27403606 DOI: 10.1117/1.JBO.21.7.075005
    Fourier transform infrared (FTIR) spectroscopy technique can detect the abnormality of a cervical cell that occurs before the morphological change could be observed under the light microscope as employed in conventional techniques. This paper presents developed features extraction for an automated screening system for cervical precancerous cell based on the FTIR spectroscopy as a second opinion to pathologists. The automated system generally consists of the developed features extraction and classification stages. Signal processing techniques are used in the features extraction stage. Then, discriminant analysis and principal component analysis are employed to select dominant features for the classification process. The datasets of the cervical precancerous cells obtained from the feature selection process are classified using a hybrid multilayered perceptron network. The proposed system achieved 92% accuracy.
  6. Zailan NA, Azizan MM, Hasikin K, Mohd Khairuddin AS, Khairuddin U
    Front Public Health, 2022;10:907280.
    PMID: 36033781 DOI: 10.3389/fpubh.2022.907280
    Due to urbanization, solid waste pollution is an increasing concern for rivers, possibly threatening human health, ecological integrity, and ecosystem services. Riverine management in urban landscapes requires best management practices since the river is a vital component in urban ecological civilization, and it is very imperative to synchronize the connection between urban development and river protection. Thus, the implementation of proper and innovative measures is vital to control garbage pollution in the rivers. A robot that cleans the waste autonomously can be a good solution to manage river pollution efficiently. Identifying and obtaining precise positions of garbage are the most crucial parts of the visual system for a cleaning robot. Computer vision has paved a way for computers to understand and interpret the surrounding objects. The development of an accurate computer vision system is a vital step toward a robotic platform since this is the front-end observation system before consequent manipulation and grasping systems. The scope of this work is to acquire visual information about floating garbage on the river, which is vital in building a robotic platform for river cleaning robots. In this paper, an automated detection system based on the improved You Only Look Once (YOLO) model is developed to detect floating garbage under various conditions, such as fluctuating illumination, complex background, and occlusion. The proposed object detection model has been shown to promote rapid convergence which improves the training time duration. In addition, the proposed object detection model has been shown to improve detection accuracy by strengthening the non-linear feature extraction process. The results showed that the proposed model achieved a mean average precision (mAP) value of 89%. Hence, the proposed model is considered feasible for identifying five classes of garbage, such as plastic bottles, aluminum cans, plastic bags, styrofoam, and plastic containers.
  7. Neo EX, Hasikin K, Mokhtar MI, Lai KW, Azizan MM, Razak SA, et al.
    Front Public Health, 2022;10:851553.
    PMID: 35664109 DOI: 10.3389/fpubh.2022.851553
    Environmental issues such as environmental pollutions and climate change are the impacts of globalization and become debatable issues among academics and industry key players. One of the environmental issues which is air pollution has been catching attention among industrialists, researchers, and communities around the world. However, it has always neglected until the impacts on human health become worse, and at times, irreversible. Human exposure to air pollutant such as particulate matters, sulfur dioxide, ozone and carbon monoxide contributed to adverse health hazards which result in respiratory diseases, cardiorespiratory diseases, cancers, and worst, can lead to death. This has led to a spike increase of hospitalization and emergency department visits especially at areas with worse pollution cases that seriously impacting human life and health. To address this alarming issue, a predictive model of air pollution is crucial in assessing the impacts of health due to air pollution. It is also critical in predicting the air quality index when assessing the risk contributed by air pollutant exposure. Hence, this systemic review explores the existing studies on anticipating air quality impact to human health using the advancement of Artificial Intelligence (AI). From the extensive review, we highlighted research gaps in this field that are worth to inquire. Our study proposes to develop an AI-based integrated environmental and health impact assessment system using federated learning. This is specifically aims to identify the association of health impact and pollution based on socio-economic activities and predict the Air Quality Index (AQI) for impact assessment. The output of the system will be utilized for hospitals and healthcare services management and planning. The proposed solution is expected to accommodate the needs of the critical and prioritization of sensitive group of publics during pollution seasons. Our finding will bring positive impacts to the society in terms of improved healthcare services quality, environmental and health sustainability. The findings are beneficial to local authorities either in healthcare or environmental monitoring institutions especially in the developing countries.
  8. Aslan MF, Hasikin K, Yusefi A, Durdu A, Sabanci K, Azizan MM
    Front Public Health, 2022;10:855994.
    PMID: 35734764 DOI: 10.3389/fpubh.2022.855994
    Artificial intelligence researchers conducted different studies to reduce the spread of COVID-19. Unlike other studies, this paper isn't for early infection diagnosis, but for preventing the transmission of COVID-19 in social environments. Among the studies on this is regarding social distancing, as this method is proven to prevent COVID-19 to be transmitted from one to another. In the study, Robot Operating System (ROS) simulates a shopping mall using Gazebo, and customers are monitored by Turtlebot and Unmanned Aerial Vehicle (UAV, DJI Tello). Through frames analysis captured by Turtlebot, a particular person is identified and followed at the shopping mall. Turtlebot is a wheeled robot that follows people without contact and is used as a shopping cart. Therefore, a customer doesn't touch the shopping cart that someone else comes into contact with, and also makes his/her shopping easier. The UAV detects people from above and determines the distance between people. In this way, a warning system can be created by detecting places where social distance is neglected. Histogram of Oriented-Gradients (HOG)-Support Vector Machine (SVM) is applied by Turtlebot to detect humans, and Kalman-Filter is used for human tracking. SegNet is performed for semantically detecting people and measuring distance via UAV. This paper proposes a new robotic study to prevent the infection and proved that this system is feasible.
  9. Sukumarran D, Hasikin K, Mohd Khairuddin AS, Ngui R, Wan Sulaiman WY, Vythilingam I, et al.
    Trop Biomed, 2023 Jun 01;40(2):208-219.
    PMID: 37650409 DOI: 10.47665/tb.40.2.013
    Timely and rapid diagnosis is crucial for faster and proper malaria treatment planning. Microscopic examination is the gold standard for malaria diagnosis, where hundreds of millions of blood films are examined annually. However, this method's effectiveness depends on the trained microscopist's skills. With the increasing interest in applying deep learning in malaria diagnosis, this study aims to determine the most suitable deep-learning object detection architecture and their applicability to detect and distinguish red blood cells as either malaria-infected or non-infected cells. The object detectors Yolov4, Faster R-CNN, and SSD 300 are trained with images infected by all five malaria parasites and from four stages of infection with 80/20 train and test data partition. The performance of object detectors is evaluated, and hyperparameters are optimized to select the best-performing model. The best-performing model was also assessed with an independent dataset to verify the models' ability to generalize in different domains. The results show that upon training, the Yolov4 model achieves a precision of 83%, recall of 95%, F1-score of 89%, and mean average precision of 93.87% at a threshold of 0.5. Conclusively, Yolov4 can act as an alternative in detecting the infected cells from whole thin blood smear images. Object detectors can complement a deep learning classification model in detecting infected cells since they eliminate the need to train on single-cell images and have been demonstrated to be more feasible for a different target domain.
  10. Neo EX, Hasikin K, Lai KW, Mokhtar MI, Azizan MM, Hizaddin HF, et al.
    PeerJ Comput Sci, 2023;9:e1306.
    PMID: 37346549 DOI: 10.7717/peerj-cs.1306
    BACKGROUND: The environment has been significantly impacted by rapid urbanization, leading to a need for changes in climate change and pollution indicators. The 4IR offers a potential solution to efficiently manage these impacts. Smart city ecosystems can provide well-designed, sustainable, and safe cities that enable holistic climate change and global warming solutions through various community-centred initiatives. These include smart planning techniques, smart environment monitoring, and smart governance. An air quality intelligence platform, which operates as a complete measurement site for monitoring and governing air quality, has shown promising results in providing actionable insights. This article aims to highlight the potential of machine learning models in predicting air quality, providing data-driven strategic and sustainable solutions for smart cities.

    METHODS: This study proposed an end-to-end air quality predictive model for smart city applications, utilizing four machine learning techniques and two deep learning techniques. These include Ada Boost, SVR, RF, KNN, MLP regressor and LSTM. The study was conducted in four different urban cities in Selangor, Malaysia, including Petaling Jaya, Banting, Klang, and Shah Alam. The model considered the air quality data of various pollution markers such as PM2.5, PM10, O3, and CO. Additionally, meteorological data including wind speed and wind direction were also considered, and their interactions with the pollutant markers were quantified. The study aimed to determine the correlation variance of the dependent variable in predicting air pollution and proposed a feature optimization process to reduce dimensionality and remove irrelevant features to enhance the prediction of PM2.5, improving the existing LSTM model. The study estimates the concentration of pollutants in the air based on training and highlights the contribution of feature optimization in air quality predictions through feature dimension reductions.

    RESULTS: In this section, the results of predicting the concentration of pollutants (PM2.5, PM10, O3, and CO) in the air are presented in R2 and RMSE. In predicting the PM10 and PM2.5concentration, LSTM performed the best overall high R2values in the four study areas with the R2 values of 0.998, 0.995, 0.918, and 0.993 in Banting, Petaling, Klang and Shah Alam stations, respectively. The study indicated that among the studied pollution markers, PM2.5,PM10, NO2, wind speed and humidity are the most important elements to monitor. By reducing the number of features used in the model the proposed feature optimization process can make the model more interpretable and provide insights into the most critical factor affecting air quality. Findings from this study can aid policymakers in understanding the underlying causes of air pollution and develop more effective smart strategies for reducing pollution levels.

  11. Alameri M, Hasikin K, Kadri NA, Nasir NFM, Mohandas P, Anni JS, et al.
    Comput Math Methods Med, 2021;2021:6953593.
    PMID: 34497665 DOI: 10.1155/2021/6953593
    Infertility is a condition whereby pregnancy does not occur despite having unprotected sexual intercourse for at least one year. The main reason could originate from either the male or the female, and sometimes, both contribute to the fertility disorder. For the male, sperm disorder was found to be the most common reason for infertility. In this paper, we proposed male infertility analysis based on automated sperm motility tracking. The proposed method worked in multistages, where the first stage focused on the sperm detection process using an improved Gaussian Mixture Model. A new optimization protocol was proposed to accurately detect the motile sperms prior to the sperm tracking process. Since the optimization protocol was imposed in the proposed system, the sperm tracking and velocity estimation processes are improved. The proposed method attained the highest average accuracy, sensitivity, and specificity of 92.3%, 96.3%, and 72.4%, respectively, when tested on 10 different samples. Our proposed method depicted better sperm detection quality when qualitatively observed as compared to other state-of-the-art techniques.
  12. Khairuddin MZF, Sankaranarayanan S, Hasikin K, Abd Razak NA, Omar R
    PeerJ Comput Sci, 2024;10:e1985.
    PMID: 38660193 DOI: 10.7717/peerj-cs.1985
    BACKGROUND: This study introduced a novel approach for predicting occupational injury severity by leveraging deep learning-based text classification techniques to analyze unstructured narratives. Unlike conventional methods that rely on structured data, our approach recognizes the richness of information within injury narrative descriptions with the aim of extracting valuable insights for improved occupational injury severity assessment.

    METHODS: Natural language processing (NLP) techniques were harnessed to preprocess the occupational injury narratives obtained from the US Occupational Safety and Health Administration (OSHA) from January 2015 to June 2023. The methodology involved meticulous preprocessing of textual narratives to standardize text and eliminate noise, followed by the innovative integration of Term Frequency-Inverse Document Frequency (TF-IDF) and Global Vector (GloVe) word embeddings for effective text representation. The proposed predictive model adopts a novel Bidirectional Long Short-Term Memory (Bi-LSTM) architecture and is further refined through model optimization, including random search hyperparameters and in-depth feature importance analysis. The optimized Bi-LSTM model has been compared and validated against other machine learning classifiers which are naïve Bayes, support vector machine, random forest, decision trees, and K-nearest neighbor.

    RESULTS: The proposed optimized Bi-LSTM models' superior predictability, boasted an accuracy of 0.95 for hospitalization and 0.98 for amputation cases with faster model processing times. Interestingly, the feature importance analysis revealed predictive keywords related to the causal factors of occupational injuries thereby providing valuable insights to enhance model interpretability.

    CONCLUSION: Our proposed optimized Bi-LSTM model offers safety and health practitioners an effective tool to empower workplace safety proactive measures, thereby contributing to business productivity and sustainability. This study lays the foundation for further exploration of predictive analytics in the occupational safety and health domain.

  13. Sukumarran D, Hasikin K, Khairuddin ASM, Ngui R, Sulaiman WYW, Vythilingam I, et al.
    Parasit Vectors, 2024 Apr 16;17(1):188.
    PMID: 38627870 DOI: 10.1186/s13071-024-06215-7
    BACKGROUND: Malaria is a serious public health concern worldwide. Early and accurate diagnosis is essential for controlling the disease's spread and avoiding severe health complications. Manual examination of blood smear samples by skilled technicians is a time-consuming aspect of the conventional malaria diagnosis toolbox. Malaria persists in many parts of the world, emphasising the urgent need for sophisticated and automated diagnostic instruments to expedite the identification of infected cells, thereby facilitating timely treatment and reducing the risk of disease transmission. This study aims to introduce a more lightweight and quicker model-but with improved accuracy-for diagnosing malaria using a YOLOv4 (You Only Look Once v. 4) deep learning object detector.

    METHODS: The YOLOv4 model is modified using direct layer pruning and backbone replacement. The primary objective of layer pruning is the removal and individual analysis of residual blocks within the C3, C4 and C5 (C3-C5) Res-block bodies of the backbone architecture's C3-C5 Res-block bodies. The CSP-DarkNet53 backbone is simultaneously replaced for enhanced feature extraction with a shallower ResNet50 network. The performance metrics of the models are compared and analysed.

    RESULTS: The modified models outperform the original YOLOv4 model. The YOLOv4-RC3_4 model with residual blocks pruned from the C3 and C4 Res-block body achieves the highest mean accuracy precision (mAP) of 90.70%. This mAP is > 9% higher than that of the original model, saving approximately 22% of the billion floating point operations (B-FLOPS) and 23 MB in size. The findings indicate that the YOLOv4-RC3_4 model also performs better, with an increase of 9.27% in detecting the infected cells upon pruning the redundant layers from the C3 Res-block bodies of the CSP-DarkeNet53 backbone.

    CONCLUSIONS: The results of this study highlight the use of the YOLOv4 model for detecting infected red blood cells. Pruning the residual blocks from the Res-block bodies helps to determine which Res-block bodies contribute the most and least, respectively, to the model's performance. Our method has the potential to revolutionise malaria diagnosis and pave the way for novel deep learning-based bioinformatics solutions. Developing an effective and automated process for diagnosing malaria will considerably contribute to global efforts to combat this debilitating disease. We have shown that removing undesirable residual blocks can reduce the size of the model and its computational complexity without compromising its precision.

  14. Abd Wahab NH, Hasikin K, Wee Lai K, Xia K, Bei L, Huang K, et al.
    PeerJ Comput Sci, 2024;10:e1943.
    PMID: 38686003 DOI: 10.7717/peerj-cs.1943
    BACKGROUND: Maintaining machines effectively continues to be a challenge for industrial organisations, which frequently employ reactive or premeditated methods. Recent research has begun to shift its attention towards the application of Predictive Maintenance (PdM) and Digital Twins (DT) principles in order to improve maintenance processes. PdM technologies have the capacity to significantly improve profitability, safety, and sustainability in various industries. Significantly, precise equipment estimation, enabled by robust supervised learning techniques, is critical to the efficacy of PdM in conjunction with DT development. This study underscores the application of PdM and DT, exploring its transformative potential across domains demanding real-time monitoring. Specifically, it delves into emerging fields in healthcare, utilities (smart water management), and agriculture (smart farm), aligning with the latest research frontiers in these areas.

    METHODOLOGY: Employing the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) criteria, this study highlights diverse modeling techniques shaping asset lifetime evaluation within the PdM context from 34 scholarly articles.

    RESULTS: The study revealed four important findings: various PdM and DT modelling techniques, their diverse approaches, predictive outcomes, and implementation of maintenance management. These findings align with the ongoing exploration of emerging applications in healthcare, utilities (smart water management), and agriculture (smart farm). In addition, it sheds light on the critical functions of PdM and DT, emphasising their extraordinary ability to drive revolutionary change in dynamic industrial challenges. The results highlight these methodologies' flexibility and application across many industries, providing vital insights into their potential to revolutionise asset management and maintenance practice for real-time monitoring.

    CONCLUSIONS: Therefore, this systematic review provides a current and essential resource for academics, practitioners, and policymakers to refine PdM strategies and expand the applicability of DT in diverse industrial sectors.

  15. Chin SY, Dong J, Hasikin K, Ngui R, Lai KW, Yeoh PSQ, et al.
    PeerJ Comput Sci, 2024;10:e2180.
    PMID: 39145215 DOI: 10.7717/peerj-cs.2180
    BACKGROUND: Bacterial image analysis plays a vital role in various fields, providing valuable information and insights for studying bacterial structural biology, diagnosing and treating infectious diseases caused by pathogenic bacteria, discovering and developing drugs that can combat bacterial infections, etc. As a result, it has prompted efforts to automate bacterial image analysis tasks. By automating analysis tasks and leveraging more advanced computational techniques, such as deep learning (DL) algorithms, bacterial image analysis can contribute to rapid, more accurate, efficient, reliable, and standardised analysis, leading to enhanced understanding, diagnosis, and control of bacterial-related phenomena.

    METHODS: Three object detection networks of DL algorithms, namely SSD-MobileNetV2, EfficientDet, and YOLOv4, were developed to automatically detect Escherichia coli (E. coli) bacteria from microscopic images. The multi-task DL framework is developed to classify the bacteria according to their respective growth stages, which include rod-shaped cells, dividing cells, and microcolonies. Data preprocessing steps were carried out before training the object detection models, including image augmentation, image annotation, and data splitting. The performance of the DL techniques is evaluated using the quantitative assessment method based on mean average precision (mAP), precision, recall, and F1-score. The performance metrics of the models were compared and analysed. The best DL model was then selected to perform multi-task object detections in identifying rod-shaped cells, dividing cells, and microcolonies.

    RESULTS: The output of the test images generated from the three proposed DL models displayed high detection accuracy, with YOLOv4 achieving the highest confidence score range of detection and being able to create different coloured bounding boxes for different growth stages of E. coli bacteria. In terms of statistical analysis, among the three proposed models, YOLOv4 demonstrates superior performance, achieving the highest mAP of 98% with the highest precision, recall, and F1-score of 86%, 97%, and 91%, respectively.

    CONCLUSIONS: This study has demonstrated the effectiveness, potential, and applicability of DL approaches in multi-task bacterial image analysis, focusing on automating the detection and classification of bacteria from microscopic images. The proposed models can output images with bounding boxes surrounding each detected E. coli bacteria, labelled with their growth stage and confidence level of detection. All proposed object detection models have achieved promising results, with YOLOv4 outperforming the other models.

  16. Pourshahrestani S, Zeimaran E, Kadri NA, Gargiulo N, Jindal HM, Hasikin K, et al.
    Mater Sci Eng C Mater Biol Appl, 2019 May;98:1022-1033.
    PMID: 30812986 DOI: 10.1016/j.msec.2019.01.022
    A novel series of silver-doped mesoporous bioactive glass/poly(1,8-octanediol citrate) (AgMBG/POC) elastomeric biocomposite scaffolds were successfully constructed by a salt-leaching technique for the first time and the effect of inclusion of different AgMBG contents (5, 10, and 20 wt%) on physicochemical and biological properties of pure POC elastomer was evaluated. Results indicated that AgMBG particles were uniformly dispersed in the POC matrix and increasing the AgMBG concentration into POC matrix up to 20 wt% enhanced thermal behaviour, mechanical properties and water uptake ability of the composite scaffolds compared to those from POC. The 20%AgMBG/POC additionally showed higher degradation rate in Tris(hydroxymethyl)-aminomethane-HCl (Tris-HCl) compared with pure POC and lost about 26% of its initial weight after soaking for 28 days. The AgMBG phase incorporation also significantly endowed the resulting composite scaffolds with efficient antibacterial properties against Escherichia coli and Staphylococcus aureus bacteria while preserving their favorable biocompatibility with soft tissue cells (i.e., human dermal fibroblast cells). Taken together, our results suggest that the synergistic effect of both AgMBG and POC make these newly designed AgMBG/POC composite scaffold an attractive candidate for soft tissue engineering applications.
  17. Zamzam AH, Al-Ani AKI, Wahab AKA, Lai KW, Satapathy SC, Khalil A, et al.
    Front Public Health, 2021;9:782203.
    PMID: 34869194 DOI: 10.3389/fpubh.2021.782203
    The advancement of technology in medical equipment has significantly improved healthcare services. However, failures in upkeeping reliability, availability, and safety affect the healthcare services quality and significant impact can be observed in operations' expenses. The effective and comprehensive medical equipment assessment and monitoring throughout the maintenance phase of the asset life cycle can enhance the equipment reliability, availability, and safety. The study aims to develop the prioritisation assessment and predictive systems that measure the priority of medical equipment's preventive maintenance, corrective maintenance, and replacement programmes. The proposed predictive model is constructed by analysing features of 13,352 medical equipment used in public healthcare clinics in Malaysia. The proposed system comprises three stages: prioritisation analysis, model training, and predictive model development. In this study, we proposed 16 combinations of novel features to be used for prioritisation assessment and prediction of preventive maintenance, corrective maintenance, and replacement programme. The modified k-Means algorithm is proposed during the prioritisation analysis to automatically distinguish raw data into three main clusters of prioritisation assessment. Subsequently, these clusters are fed into and tested with six machine learning algorithms for the predictive prioritisation system. The best predictive models for medical equipment's preventive maintenance, corrective maintenance, and replacement programmes are selected among the tested machine learning algorithms. Findings indicate that the Support Vector Machine performs the best in preventive maintenance and replacement programme prioritisation predictive systems with the highest accuracy of 99.42 and 99.80%, respectively. Meanwhile, K-Nearest Neighbour yielded the highest accuracy in corrective maintenance prioritisation predictive systems with 98.93%. Based on the promising results, clinical engineers and healthcare providers can widely adopt the proposed prioritisation assessment and predictive systems in managing expenses, reporting, scheduling, materials, and workforce.
  18. Pourshahrestani S, Kadri NA, Zeimaran E, Gargiulo N, Samuel S, Naveen SV, et al.
    Biomed Mater, 2018 02 08;13(2):025020.
    PMID: 29148431 DOI: 10.1088/1748-605X/aa9b3e
    Mesoporous bioactive glass containing 1% Ga2O3 (1%Ga-MBG) is attractive for hemorrhage control because of its surface chemistry which can promote blood-clotting. The present study compares this proprietary inorganic coagulation accelerator with two commercial hemostats, CeloxTM (CX) and QuikClot Advanced Clotting Sponge PlusTM (ACS+). The results indicate that the number of adherent platelets were higher on the 1%Ga-MBG and CX surfaces than ACS+ whereas a greater contact activation was seen on 1%Ga-MBG and ACS+ surfaces than CX. 1%Ga-MBG not only resulted in larger platelet aggregates and more extensive platelet pseudopodia compared to CX and ACS+ but also significantly accelerated the intrinsic pathways of the clotting cascade. In vitro thrombin generation assays also showed that CX and ACS+ induced low levels of thrombin formation while 1%Ga-MBG had significantly higher values. 1%Ga-MBG formed a larger red blood cell aggregate than both CX and ACS+. Direct exposure of 1%Ga-MBG to fibroblast cells increased cell viability after 3 days relative to CX and ACS+, inferring excellent cytocompatibility. The results of this study promote 1%Ga-MBG as a promising hemostat compared to the commercially available products as it possesses essential factors required for coagulation activation.
  19. Khairuddin MZF, Lu Hui P, Hasikin K, Abd Razak NA, Lai KW, Mohd Saudi AS, et al.
    Int J Environ Res Public Health, 2022 Oct 27;19(21).
    PMID: 36360843 DOI: 10.3390/ijerph192113962
    Forecasting the severity of occupational injuries shall be all industries' top priority. The use of machine learning is theoretically valuable to assist the predictive analysis, thus, this study attempts to propose a feature-optimized predictive model for anticipating occupational injury severity. A public database of 66,405 occupational injury records from OSHA is analyzed using five sets of machine learning models: Support Vector Machine, K-Nearest Neighbors, Naïve Bayes, Decision Tree, and Random Forest. For model comparison, Random Forest outperformed other models with higher accuracy and F1-score. Therefore, it highlighted the potential of ensemble learning as a more accurate prediction model in the field of occupational injury. In constructing the model, this study also proposed the feature optimization technique that revealed the three most important features; 'nature of injury', 'type of event', and 'affected body part' in developing model. The accuracy of the Random Forest model was improved by 0.5% or 0.895 and 0.954 for the prediction of hospitalization and amputation, respectively by redeveloping and optimizing the model with hyperparameter tuning. The feature optimization is essential in providing insight knowledge to the Safety and Health Practitioners for future injury corrective and preventive strategies. This study has shown promising potential for smart workplace surveillance.
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