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Fulltext Ergonomic design of a computer keyboard layout for the Jawi script

Shahrul Kamaruddin, Beng, S.C., Khan, Zahid A.

Pertanika Journal of Science & Technology, 2010;18(2):-.
MyJurnal

Due to unavailability of a computer keyboard layout for the Jawi script, users of this script make use of the Arabic keyboard layout for typing texts in this particular script. Obviously, the layout of the Arabic script keyboard is not designed for the ancient writing of the Jawi script. Keeping this in view, a research was conducted to design a new keyboard layout suitable for the users of the Jawi script from an ergonomics point of view, and the outcome of the research is presented in this study. In order to design the Jawi script keyboard layout, the relative finger strengths of both male and female subjects were determined experimentally. The relative frequency of the characters and two special characters (full-stop and comma) that appeared in the script were determined by counting their presence in a large number of texts in the script that represent the workload of the fingers. The keys were rearranged in such a way that the workload of each finger was approximately matched with its relative strength. The newly proposed arrangement of the keys was not much different compared to the Arabic script keyboard layout, and hence it is convenient for users to switch between the layouts.
Fulltext The control chart technique for the detection of the problem of bad data in state estimation power system

Khan, Zahid, Radzuan Razali, Hanita Daud, Nursyarizal Mohd Nor, Fotuhi-Firuzabad, Mahmud

Pertanika Journal of Science & Technology, 2017;25(3):825-834.
MyJurnal

State estimation plays a vital role in the security analysis of a power system. The weighted least squares method is one of the conventional techniques used to estimate the unknown state vector of the power system. The existence of bad data can distort the reliability of the estimated state vector. A new algorithm based on the technique of quality control charts is developed in this paper for detection of bad data. The IEEE 6-bus power system data are utilised for the implementation of the proposed algorithm. The output of the study shows that this method is practically applicable for the separation of bad data in the problem of power system state estimation.
Fulltext Hemodynamic monitoring and outcome-a physiological appraisal

Chan YK, Khan ZH

Acta Anaesthesiol Taiwan, 2011 Dec;49(4):154-8.
PMID: 22221689 DOI: 10.1016/j.aat.2011.11.002

Hemodynamic monitoring provides us with refined details about the cardiovascular system. In spite of increased availability of the monitoring process and monitoring equipment, hemodynamic monitoring has not significantly improved survival outcome. Care providers should be cognizant of the role of the cardiovascular system and its importance in oxygen delivery to the cells in order to sustain life. Effective hemodynamic monitoring should be able to delineate how well the system is performing in carrying out this role. Different hemodynamic monitors serve in this role to a different extent; some provide very little information on this. The cardiovascular system is only one of the many systems that need to function optimally for survival; others of equal importance include the integrity of the airway, the breathing process, the adequacy of hemoglobin level, and the health of the tissue bed, especially in the brain and the heart. Advances in hemodynamic monitoring with focus on oxygen delivery at the cellular level may ultimately provide the edge to effective monitoring that can impact outcome.
Fulltext Novel derivative of aminobenzenesulfonamide (3c) induces apoptosis in colorectal cancer cells through ROS generation and inhibits cell migration

Al-Khayal K, Alafeefy A, Vaali-Mohammed MA, Mahmood A, Zubaidi A, Al-Obeed O, et al.

BMC Cancer, 2017 01 03;17(1):4.
PMID: 28049506 DOI: 10.1186/s12885-016-3005-7

BACKGROUND: Colorectal cancer (CRC) is the 3(rd) most common type of cancer worldwide. New anti-cancer agents are needed for treating late stage colorectal cancer as most of the deaths occur due to cancer metastasis. A recently developed compound, 3c has shown to have potent antitumor effect; however the mechanism underlying the antitumor effect remains unknown.
METHODS: 3c-induced inhibition of proliferation was measured in the absence and presence NAC using MTT in HT-29 and SW620 cells and xCELLigence RTCA DP instrument. 3c-induced apoptotic studies were performed using flow cytometry. 3c-induced redox alterations were measured by ROS production using fluorescence plate reader and flow cytometry and mitochondrial membrane potential by flow cytometry; NADPH and GSH levels were determined by colorimetric assays. Bcl2 family protein expression and cytochrome c release and PARP activation was done by western blotting. Caspase activation was measured by ELISA. Cell migration assay was done using the real time xCELLigence RTCA DP system in SW620 cells and wound healing assay in HT-29.
RESULTS: Many anticancer therapeutics exert their effects by inducing reactive oxygen species (ROS). In this study, we demonstrate that 3c-induced inhibition of cell proliferation is reversed by the antioxidant, N-acetylcysteine, suggesting that 3c acts via increased production of ROS in HT-29 cells. This was confirmed by the direct measurement of ROS in 3c-treated colorectal cancer cells. Additionally, treatment with 3c resulted in decreased NADPH and glutathione levels in HT-29 cells. Further, investigation of the apoptotic pathway showed increased release of cytochrome c resulting in the activation of caspase-9, which in turn activated caspase-3 and -6. 3c also (i) increased p53 and Bax expression, (ii) decreased Bcl2 and BclxL expression and (iii) induced PARP cleavage in human colorectal cancer cells. Confirming our observations, NAC significantly inhibited induction of apoptosis, ROS production, cytochrome c release and PARP cleavage. The results further demonstrate that 3c inhibits cell migration by modulating EMT markers and inhibiting TGFβ-induced phosphorylation of Smad2 and Samd3.
CONCLUSIONS: Our findings thus demonstrate that 3c disrupts redox balance in colorectal cancer cells and support the notion that this agent may be effective for the treatment of colorectal cancer.
Fulltext Evaluating CNC Milling Performance for Machining AISI 316 Stainless Steel with Carbide Cutting Tool Insert

Equbal A, Equbal MA, Equbal MI, Ravindrannair P, Khan ZA, Badruddin IA, et al.

Materials (Basel), 2022 Nov 15;15(22).
PMID: 36431537 DOI: 10.3390/ma15228051

The present study investigates the CNC milling performance of the machining of AISI 316 stainless steel using a carbide cutting tool insert. Three critical machining parameters, namely cutting speed (v), feed rate (f) and depth of cut (d), each at three levels, are chosen as input machining parameters. The face-centred central composite design (FCCCD) of the experiment is based on response surface methodology (RSM), and machining performances are measured in terms of material removal rate (MRR) and surface roughness (SR). Analysis of variance, response graphs, and three-dimensional surface plots are used to analyse experimental results. Multi-response optimization using the data envelopment analysis based ranking (DEAR) approach is used to find the ideal configuration of the machining parameters for milling AISI 316 SS. The variables v = 220 m/min, f = 0.20 mm/rev and d = 1.2 mm were obtained as the optimal machine parameter setting. Study reveals that MRR is affected dominantly by d followed by v. For SR, f is the dominating factor followed by d. SR is found to be almost unaffected by v. Finally, it is important to state that this work made an attempt to successfully machine AISI 316 SS with a carbide cutting tool insert, to investigate the effect of important machining parameters on MRR and SR and also to optimize the multiple output response using DEAR method.
Fulltext Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Khan A, Muhamad NA, Ismail H, Nasir A, Khalil AAK, Anwar Y, et al.

Plants (Basel), 2020 Oct 22;9(11).
PMID: 33105854 DOI: 10.3390/plants9111414

Crocus sativus, a medicinally important herbaceous plant, has been traditionally used to cure coughs, colds, insomnia, cramps, asthma, and pain. Moreover, the therapeutic applications of saffron include its immunomodulatory and anticancer properties. The current experimental analysis was performed to explore the potential nutraceutical efficacy of corm, leaf, petal, and stigma of saffron ethanolic extracts as analgesic, anti-inflammatory, anticoagulant, and antidepressant using hot plate, carrageenan-induced paw edema, capillary tube and forced swim test, respectively in mice. The results indicated that among all the extracts, stigma ethanolic extract (SEE) represented maximum latency activity (72.85%) and edema inhibition (77.33%) followed by petal ethanolic extract (PEE) with latency activity and edema inhibition of 64.06 and 70.50%, respectively. Corm ethanolic extract (CEE) and leaf ethanolic extract (LEE) displayed mild analgesic activity of 22.40% and 29.07%, respectively. Additionally, LEE (53.29%) and CEE (47.47%) exhibited mild to moderate response against inflammation. The coagulation time of SEE (101.66 s) was almost equivalent to the standard drug, aspirin (101.66 s), suggesting a strong anticoagulant effect followed by PEE (86.5 s). LEE (66.83 s) represented moderate inhibitory effect on coagulation activity while CEE (42.83 s) showed neutral effect. Additionally, PEE and SEE also expressed itself as potential antidepressants with immobility time ≤76.66 s, while CEE (96.50 s) and LEE (106.83 s) indicated moderate to mild antidepressant efficacy. Based on the in vivo activities, saffron extract, particularly SEE and PEE, can be used as a potential nutraceutical and therapeutic agent due to its significant pharmacological activities.
Fulltext Global Burden of Anorexia Nervosa and Bulimia Nervosa, 1990 to 2023, With Forecasts to 2050: A Global Burden of Disease Study 2023 Analysis

Bai R, Dong W, Wang X, Zhang A, Santomauro DF, GBD Eating Disorders Collaborators, et al.

JAMA Psychiatry, 2026 Oct 28.
PMID: 42949727 DOI: 10.1001/jamapsychiatry.2026.3457

IMPORTANCE: Eating disorders are a major cause of nonfatal mental health burden, yet global evidence on their long-term trends, geographic distribution, and future trajectories remains limited.
OBJECTIVE: To estimate the global, regional, and national prevalence and disability burden of anorexia nervosa and bulimia nervosa-and mortality attributable to anorexia nervosa-from 1990 to 2023, and to forecast prevalence to 2050.
DESIGN, SETTING, AND PARTICIPANTS: Using Global Burden of Disease (GBD) 2023 methods, data were synthesized from systematic literature reviews, population surveys, and vital registration systems. Estimates were produced for 204 countries and territories from 1990 to 2023, with forecasts through 2050. These data were analyzed from October 2025 to August 2026.
EXPOSURE: Anorexia nervosa or bulimia nervosa diagnosis.
MAIN OUTCOMES AND MEASURES: Counts and age-standardized rates with 95% uncertainty intervals (UIs) for anorexia nervosa and bulimia nervosa prevalence, years lived with disability (YLDs), and disability-adjusted life-years (DALYs), and anorexia nervosa mortality, reported by age, sex, and location.
RESULTS: In 2023, an estimated 18.1 million people (95% UI, 13.9-24.0) globally were living with anorexia nervosa or bulimia nervosa, of whom 12.6 million (69.4%) were female, 5.5 million were male (30.6%), and 41.2% were aged 10 to 24 years. These cases accounted for 3.83 million DALYs (95% UI, 2.23-5.69). Since 1990, the global number of prevalent cases increased by 71.0%, while age-standardized prevalence and DALY rates rose by about 21%. Females experienced substantially higher prevalence and DALY rates than males. The highest age-standardized prevalence rates were observed in high-income regions, particularly Australasia and Western Europe, whereas the largest relative increases in age-standardized prevalence occurred in East Asia, South Asia, and Southeast Asia. Forecasts indicate continued increases in prevalent cases through 2050.
CONCLUSIONS AND RELEVANCE: This GBD 2023 analysis found that anorexia nervosa and bulimia nervosa contribute substantially to global nonfatal health loss. These findings support the integration of eating disorders into mental health surveillance, prevention, and service planning worldwide.