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  1. Adibah, I., Wan Abu Bakar, W.Y., Nik Mohamed Zaki, N.M., Nik Hazlina, N.H., Venkatesh, R.N.
    MyJurnal
    Endometrial stromal sarcoma is a rare tumour of the uterus. We reported a case of a young lady with endometrial stromal sarcoma. She became pregnant while having the disease and delivered a healthy baby, her sixth, without any complication. A total abdominal hysterectomy with bilateral oopherectomy was performed subsequently. She refused any added treatment after the operation. To date, she is free of any recurrence.
  2. Lai, Sue Yi, Soon, Lean Keng, Nik Mohamed Zaki Nik Mahmood, Naji Mahat
    MyJurnal
    The prevalence of gestational diabetes mellitus (GDM) is increasing worldwide and even in Malaysia. Hence, the knowledge of adiponectin with regards to gestational diabetes mellitus is a key contributor to disparity in maternal and neonatal morbidities. This study aimed to assess nurses' knowledge of adiponectin and its association with gestational diabetes and obesity in pregnancy. A cross-sectional survey was employed. Respondents were selected by purposive sampling using a pre-tested, structured questionnaire. Ninety one nurses (100%) were aware that obesity increased adverse health outcome among pregnant women, but some confusion exits among nurses about adiponectin with regards to pregnancy. Most of the nurses lack condence in providing care to pregnant women with many (82.4%) addressed the need for education on this topic. In the one-way ANOVA analysis, nurses' knowledge score was significantly associated with education level (p<0.001) and working experience in maternity units (p<0.001). This study demonstrates gaps in the knowledge of adiponectin and its association with obesity and pregnancy. Continuous nursing education for nurses on adiponectin and obesity-related issues in early pregnancy should be strengthened to enhance knowledge and confidence in providing quality antenatal services.
    Keywords : Nurses, adiponectin, obesity, pregnancy, gestational diabetes
  3. Win TT, Nik Mahmood NMZ, Ma SO, Ismail M
    Iran J Pathol, 2016;11(5):478-482.
    PMID: 28974971
    Clear cell carcinoma of ovary is uncommon ovarian tumour that arises from surface epithelium of ovary. It has well-known association with ovarian endometriosis. We report here the first case of bilateral clear cell carcinoma of ovaries in a 40-year-old woman with a 17-year history of bilateral ovarian endometriosis. In addition, during the longstanding duration of the endometriosis, the patient was treated with hormonal therapy, including oestrogen. It represents the first report of such bilateral involvement in the background of ovarian endometriosis. This should prompt clinicians to be aware that prolonged hormonal treatment of endometriosis may precipitate bilateral malignancy of the ovary.
  4. Marhazlina Mohamad, Loy, See-Ling, Nik Mohamed Zaki Nik Mahmood, Nor Azwany Yaacob, Hamid Jan Jan Mohamed
    MyJurnal
    This study aimed to develop and examine the validity and reliability of a pregnancy symptoms questionnaire. A total of 214 pregnant women aged 19 to 40 years old were purposive randomly recruited from December 2009 to January 2010 in Antenatal Clinic, Hospital Universiti Sains Malaysia. Pregnant mothers at second and third trimesters were interviewed to complete the Pregnancy Symptoms Questionnaire (PSQ). The PSQ was developed by experts in nutrition, obstetrics and statistics. The PSQ consists of 38 items on frequency and severity of pregnancy symptoms. Factor analysis was done using Promax rotation method to check for construct validity. A total of 16 items which had poor correlation (<0.3) and less important content were removed during the final revise. The 22 remaining items were found to be loaded on the three components (general, constitutional and somatic pain). The overall Cronbach’s alpha coefficient was 0.93 and for each three components ranges from 0.70–0.87. The results suggest that the final PSQ consisting of 22 items is valid and reliable for measuring the frequency and severity of the symptoms experienced during pregnancy. It can be used in nutritional studies related to pregnancy and its outcome.
    Keywords: Pregnant mothers; Pregnancy symptoms; Questionnaire; Validation
    Study site: Antenatal Clinic, Hospital Universiti Sains Malaysia (HUSM), Kelantan, Malaysia
  5. W Adnan WF, Nik Mahmood NMZ, Ismail MP, Mohamad Zon E, Othman MS, Kamaludin Z
    Cancer Treat Res Commun, 2022;33:100660.
    PMID: 36455511 DOI: 10.1016/j.ctarc.2022.100660
    BACKGROUND: Endometrial cancer in young women (less than 40-year-old) is associated with anovulatory menses, polycystic ovarian syndrome (PCOS) and subfertility. Endometrial cancer occurring in a miscarriage is rare. We highlight a case of endometrial cancer occurring during miscarriage of a non-viable pregnancy, its management and the outcome.

    CASE: A 32-year-old woman, Gravida 1 Para 0, was referred to our center at 7 weeks gestation in 2018 for uncontrolled diabetes mellitus diagnosed during investigation for subfertility. Her poor compliance with the treatment is consistent with an HbA1c of 8%. During the assessment, she was already complaining of lower abdominal pain. Ultrasound showed irregular IUGS with no fetal echo. She had a miscarriage soon; however, due to ultrasound evidence of thickened and irregular endometrium (17 mm) with mixed echogenicity, dilatation and curettage (D + C) were commenced. The first and second tissues were reported as the product of conception (POC) and well differentiated endometrioid adenocarcinoma, respectively. The first hysteroscopy showed foci area of polypoidal growth at the right posterior endometrium, obscuring the right ostium, with similar histology report. She was commenced on high-dose progestogen with hysteroscopy surveillance 6 months later, which showed disease regression. After two normal hysteroscopies and endometrial biopsies with continuous progestogen therapy for 12 months, cyclical progestogen for 12 months and follow-up for another 6 months, she had spontaneous conception and is currently pregnant at 16 weeks gestation.

    CONCLUSION: Endometrial cancer should be suspected in high-risk patients with first-trimester miscarriage. Individualized treatment with high dose progestogen and follow-up with the proper patient and partner counselling and education has high successful regressionand later on, pregnancy rate.

  6. Rahman MT, Naik VR, Noor SR, Mahmud NM, Isa M
    Malays J Med Sci, 2003 Jul;10(2):93-5.
    PMID: 23386805
    A 66-year-old Malay woman, known hypertensive, presented with post menopausal bleeding associated with clot for three months. She was postmenopausal for last ten years. She also complaints of developing a mass in the abdomen which was growing in size also for last three months. Abdominal examination revealed a twenty week size mass, movable from side to side but unable to get below the mass. Vaginal examination revealed a fleshy fungating mass arising from the uterus coming out through the vagina. Cervix could not be visualized properly. Subsequent histopathology of the removed mass was reported as a Malignant Mixed Mullerian Tumour - Heterologous.
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