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  1. Nurulnadia MY, Koyama J, Uno S, Amano H
    Chemosphere, 2016 Feb;144:185-92.
    PMID: 26363319 DOI: 10.1016/j.chemosphere.2015.08.059
    We evaluated the potential for biomagnification of endocrine disrupting chemicals (EDCs) such as nonylphenol (NP), octylphenol (OP), bisphenol A (BP), and natural estrogens such as estrone (E1) and 17β-estradiol (E2) in a benthic fish, Pleuronectes yokohamae. The assimilation efficiencies (AE) of most EDCs ranged from 88 to 96% suggesting that they were efficiently incorporated and assimilated into P. yokohamae, except for NP (50%). However, the biomagnification factor (BMF) values were <1.0 suggesting that the compounds were not biomagnifying. Additionally, three of the target EDCs were not detected (BP, E1 and E2). Glucuronidation activity towards BP (11.44 ± 2.5 nmol/mg protein/min) and E2 (12.41 ± 3.2 nmol/mg protein/min) was high in the intestine suggesting that EDCs were glucuronidated prior to excretion into bile. Thus, we conclude that biomagnification of dietary EDCs is reduced in P. yokohamae because of effective glucuronidation.
  2. Wahab RA, Omar TFT, Nurulnadia MY, Rozulan NNA
    Mar Pollut Bull, 2023 Jul;192:115036.
    PMID: 37207388 DOI: 10.1016/j.marpolbul.2023.115036
    The concentration, distribution, and risk assessment of parabens were determined in the surface water of the Terengganu River, Malaysia. Target chemicals were extracted via solid-phase extraction, followed by high-performance liquid chromatography analysis. Method optimization produced a high percentage recovery for methylparaben (MeP, 84.69 %), ethylparaben (EtP, 76.60 %), and propylparaben (PrP, 76.33 %). Results showed that higher concentrations were observed for MeP (3.60 μg/L) as compared with EtP (1.21 μg/L) and PrP (1.00 μg/L). Parabens are ubiquitously present in all sampling stations, with >99 % of detection. Salinity and conductivity were the major factors influencing the level of parabens in the surface water. Overall, we found no potential risk of parabens in the Terengganu River ecosystem due to low calculated risk assessment values (risk quotient 
  3. Ariffin MM, Adiana G, Bidai J, Hing LS, Nurulnadia MY, Ong MC, et al.
    Data Brief, 2019 Dec;27:104806.
    PMID: 31788520 DOI: 10.1016/j.dib.2019.104806
    Metals are natural elements existed in the environment. However, due to the rapid development of urbanisation and economic, high content of anthropogenic metals are being perceived in polluting the environment. The oceans are known to be a part of the sinking basin for anthropogenic metals ends. Dataset provided is purposely to give an overview of dissolved metals spatial distribution in the South China Sea off the east Peninsular of Malaysia during the pre-, post- and Northeast (NE) Monsoon period. Seawater samples were collected in a grid of 18 stations at 3 different water depth. Dissolved metals were pre-concentrated on-board ship using Chelex-100 resin and analysed using Inductively Coupled Plasma Mass Spectrophotometry (ICPMS). The dataset shows the effect of NE Monsoon on dissolved metals spatial distribution mainly at the area closer to the land. Therefore, this dataset could reveal the past information on anthropogenic metals intrusion in the South China Sea, since Terengganu state was recently pointed to be one of the Malaysian waterfront city. Additionally, this dataset also could help in studying the cycle of metals in the southern South China Sea waters.
  4. Nurulnadia MY, Zahid BM, Yusof KMKK, Minhat FI, Uno S, Hamid HIA
    Environ Monit Assess, 2023 Feb 02;195(3):355.
    PMID: 36732460 DOI: 10.1007/s10661-023-10998-0
    Sediment is the ultimate reservoir of effluent from landmasses. This includes octylphenol (OP) and nonylphenol (NP), two chemical compounds which are known with the ability to disrupt the normal functions of hormones in the organism. To our knowledge, no study of these compounds in the marine sediment of Malaysia has been published to date. Hence, this study presents the level of OP and NP in the sediment of the South China Sea and Malacca Strait, Malaysia. The extraction of compounds was done using the liquid-liquid extraction method and followed by clean-up using solid-phase extraction cartridges. The range of OP in Malacca Strait (1.00-27.16 ng/g dw) was greater than in the South China Sea (5.12-14.16 ng/g dw) whereas a similar range of NP was found in the South China Sea (1.32-23.76 ng/g dw) and Malacca Strait (0.79-27.59 ng/g dw). The concentration of both compounds was consistently high near Redang Island (E2A) and Penang (W32 and W43) suggesting continuous input of these chemicals from this nearby land. Risk quotient (RQ) values of OP showed the potential risk to benthic communities in 4/7 and 21/47 sampling points of the respective South China Sea and Malacca Strait. Both water bodies are located far from the wastewater effluent and yet able to retain these chemicals in their sediment. This suggests that the wastewater treatment system as well as dilution effects do not prevent these chemicals to be ended up in the marine environment.
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